Introduction ​

The overarching theme of the research in our group is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to protein sequences.

We are intrigued by the parallelism between computation and the processing of information encoded in biological sequences. The bulk of our research currently focuses on the mechanisms underlying RNA production (transcription) and post-processing (splicing), and it is increasingly incorporating high throughput and experimental approaches.

We have recently become interested in the investigation of endophenotypes, specifically histopathological images, and we are developing computational methods to relate histological features to cellular and molecular phenotypes (mostly single-cell and bulk tissue transcriptomics) and to organismic phenotypes (i.e. diseases).

Research lines in our group are:

• Epigenetic regulation of gene expression
• Gene prediction, genome annotation, comparative genomics
• Large-scale functional genomics
• The impact of genetic variation in molecular and intermediate phenotypes
• Identification and evolution of selenoproteins