ID HS307871 standard; genomic DNA; HUM; 4514 BP.
XX
AC U30787; X06048;
XX
SV U30787.1
XX
DT 18-MAY-1996 (Rel. 47, Created)
DT 30-JUN-1999 (Rel. 60, Last updated, Version 2)
XX
DE Human uroporphyrinogen decarboxylase (URO-D) gene, complete cds.
XX
KW .
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 785-1143
RX MEDLINE; 88015599.
RX PUBMED; 3658695.
RA Romana M., Dubart A., Beaupain D., Chabret C., Goossens M., Romeo P.H.;
RT "Structure of the gene for human uroporphyrinogen decarboxylase";
RL Nucleic Acids Res. 15(18):7343-7356(1987).
XX
RN [2]
RP 1-4514
RX MEDLINE; 96220222.
RX PUBMED; 8644733.
RA Moran-Jimenez M.J., Ged C., Romana M., Enriquez De Salamanca R., Taieb A.,
RA Topi G., D'Alessandro L., de Verneuil H.;
RT "Uroporphyrinogen decarboxylase: complete human gene sequence and molecular
RT study of three families with hepatoerythropoietic porphyria";
RL Am. J. Hum. Genet. 58(4):712-721(1996).
XX
RN [3]
RP 1-4514
RA Romana M., Ged C., Verneuil H.;
RT ;
RL Submitted (30-JUN-1995) to the EMBL/GenBank/DDBJ databases.
RL Cecile Ged, Biochimie Medicale et Moleculaire, University of Bordeaux II,
RL 146 rue Leo Saignat, Bordeaux, France
XX
DR EPD; EP17059; HS_DCUP.
DR GOA; P06132.
DR SWISS-PROT; P06132; DCUP_HUMAN.
XX
CC On May 17, 1996 this sequence version replaced gi:37613.
XX
FH Key Location/Qualifiers
FH
FT source 1..4514
FT /db_xref="taxon:9606"
FT /mol_type="genomic DNA"
FT /organism="Homo sapiens"
FT protein_bind 1028..1037
FT /bound_moiety="Sp1"
FT TATA_signal 1066..1073
FT mRNA join(1089..1126,1748..1860,1976..2055,2132..2194,
FT 2434..2631,2749..2910,3279..3416,3576..3676,3780..3846,
FT 4179..4514)
FT /gene="URO-D"
FT /product="uroporphyrinogen decarboxylase"
FT gene 1089..4514
FT /gene="URO-D"
FT CDS join(1107..1126,1748..1860,1976..2055,2132..2194,
FT 2434..2631,2749..2910,3279..3416,3576..3676,3780..3846,
FT 4179..4340)
FT /codon_start=1
FT /db_xref="GOA:P06132"
FT /db_xref="SWISS-PROT:P06132"
FT /gene="URO-D"
FT /product="uroporphyrinogen decarboxylase"
FT /protein_id="AAC50482.1"
FT /translation="MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPE
FT FRETRAAQDFFSTCRSPEACCELTLQPLRRFLLDAAIIFSDILVVPQALGMEVTMVPGK
FT GPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMT
FT YMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAG
FT HLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVG
FT LDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHG
FT LYPDMDPEHVGAFVDAVHKHSRLLRQN"
XX
SQ Sequence 4514 BP; 984 A; 1159 C; 1197 G; 1174 T; 0 other;
aagcttcgta agcacctctc gcggcacgaa agccagcgct gcctaggcgc cgcccggcgc 60
gaggctctca cctctgccaa gaagcgcacc ggcccagcag ctgccggggg gactccagca 120
ccgcgccggg ccatggaccc gccatgagtc agctggcgcg accgcggaca gagcttccca 180
ccacgccctt ccccgccttt ggccagcctt tgccgtatgt tctggactaa gcgcacccca 240
gctctcactg tattggactg tgtactccca cactcaacca tattacttat ctctgtgcca 300
ccctaaccca gccgaccaaa cccaagattg gtgattgcta cctgatcaat ctccctctct 360
ccatttcctt gtgactacca ttttatctct actgctacta ccctcattca agtcaccatt 420
ctagctagcc tgggtcattg ccaacagtca tttttctggt tcttcggcct gctgtttttc 480
ctcccactcc cagcgaatct gctggactcc ctatcctatg ggtggtgtga ttaaagtgtt 540
tgagacaatg gccccttccc ctgccactga caggagtctt gagtcattag ggttgagttc 600
tgtttgacac tcctaatccc aaggacactg gagatcatta ttcattttaa tgtgattgct 660
gatttctgtt tccccagtct tgtagctcct taaaggctgg ggtgtcttga gcagagctaa 720
cctctgcacc tactataggt ccaggctata gtatggacct ggctggataa gactgttggt 780
atcatagttg ggacttgcgc caagctccgg atacccagac tgtcagatga gaacaaattc 840
ctcatgtcac cgtaagatac atttacagcg gagttttctt ttgggccttt gttgtttcgt 900
cgctacagca aactttacgg tgaaaaaagg taggggtcta cggcagcagc agggcagccc 960
tggagctgtc gctggagtcc gatcatgtga tcttcaacat ggcgacgctc ttggttccct 1020
acagaaaggg gcggagcctg gactgggggg caggctcaga ttcaggttaa attgtggatt 1080
gagctcgcag ttacagacag ctgaccatgg aagcgaatgg gttggggtga gttctccaga 1140
gcacgcggtg tggctagccg ggcttctaat ttgagtcttc caactcagga ctctatccct 1200
ctactcccct ttccccaccc tggagaacct cccaacctga actccgttag ctggatcctg 1260
aatcctaaaa ccatggattt ttgagatgtt catcccaggg ccttaattca agggatgcct 1320
caggatttcc aaccaggatc ttcattctgg gaccatcaac tctgatccct ctttatcccc 1380
cagcctgggt atttctcagc ccctgaacca gcccagtgac atttcccggt ttctgaggct 1440
cactagttcg aagaccccca aactatcctt agtgggcctt cattccctcc ccccagtccc 1500
tctggttgct tcgagcttgg aagagtagag actaagtgga gggaagaggc cccagggcgg 1560
gcccttctgg agtttgtgca ctgataggca gagaggaggc ggaacgggcg gaaagccagg 1620
gtttgggagc tggcctggag gaggtaggat agcggtcctg gactgaatcg gccttatgaa 1680
cccgcgcttt ccccagccgt ccaacgtagc atactgacac ctacccccac ccccacctga 1740
tcgccagacc tcagggtttt ccggagctga agaatgacac attcctgcga gcagcctggg 1800
gagaggaaac agactacact cccgtttggt gcatgcgcca ggcaggccgt tacttaccag 1860
gtaagagtca gggtctggaa atctagataa aactccggag gagaaaagtt ttcgaggggc 1920
aggggagggc tctggagggc ctcaaggctg agccctgtct tccctctgta tgcagagttt 1980
agggaaaccc gggctgccca ggactttttc agcacgtgtc gctctcctga ggcctgctgt 2040
gaactgactc tgcaggtgag gggtccacaa aagagggaaa gatttatgcc ttcagtctgc 2100
cacctagcaa cctgtctcct gtttcctaca gccactgcgt cgcttccttc tggatgctgc 2160
catcattttc tccgacatcc ttgttgtacc ccaggtaccc actcaaacct gatcctagaa 2220
tataatccaa ggacgccttg aaaatccttc tatcagtcca gtcaaggttt acaataagca 2280
cttatcctaa ctggatcgag ggaaaaacta aggttgaaag aaatggagtt tggcagagtt 2340
ttattctcct tttccttcct cctggaatga gctgaacaga acctttcctc ctggattcca 2400
ttttgggaac ccagatgttt tctccccctc caggcactgg gcatggaggt gaccatggta 2460
cctggcaaag gacccagctt cccagagcca ttaagagaag agcaggacct agaacgccta 2520
cgggatccag aagtggtagc ctctgagcta ggctatgtgt tccaagccat cacccttacc 2580
cgacaacgac tggctggacg tgtgccgctg attggctttg ctggtgcccc agtaatgtgg 2640
gacagggcag ggactcgggg cgcggggaga tcactctgga aggtctgggg tagacaaaag 2700
gaagggtcag tctggcttct gtgacaccat ctttctatcc ttctctagtg gaccctgatg 2760
acatacatgg ttgagggtgg tggctcaagc accatggctc aggccaagcg ctggctctat 2820
cagagacctc aggctagtca ccagctgctt cgcatcctca ctgatgctct ggtcccatat 2880
ctggtaggac aagtggtggc tggtgcccag gtgagtcctg agagagagag aaataggctg 2940
ggatttggtc tgtaaggccg agaagcaaga gtgtcctaaa cctgagaggg caggggtctt 3000
aatgctaggg atgaaagaac cttggcctcc agtgatctag ctgagcagcc aagcccatcc 3060
tgacactgac agtggggctt aatgctctaa gtattcagac accaaagtta gtgctgggat 3120
ctgaggaaag taaatttttt tttttttaat tactgggttt ttagggtcag gcagtatcag 3180
ggattgaagt catttgggga aaattgaggt ggattttgta tgtgggggaa acttcctctt 3240
tgtgtgttac atatttttct tcaccatacc ctaactaggc attgcagctg tttgagtccc 3300
atgcagggca tcttggccca cagctcttca acaagtttgc actgccttac atccgtgatg 3360
tggccaagca agtgaaggcc aggttgcggg aggcaggcct ggcaccagtg cccatggtga 3420
ggattgggat gggttgagtg aaggtggtcc tgtggagctt tcaggctaag tcctgcatgg 3480
actggagtga ccactggagg gcagcagaag tacagtcaag aaagattagt ggttgtagca 3540
aggccctctg tagcctgaga tctgcttttt tctagatcat ctttgctaag gatgggcatt 3600
ttgccctgga ggagctggcc caagctggct atgaggtggt tgggcttgac tggacagtgg 3660
ccccaaagaa agcccggtaa gccatggaag ggtgaggcct tgaggttgag gtgggggtgt 3720
tggctggggg agctgccatg tatgcagtta ccagaacgtg gcgctggctt tgcttccagg 3780
gagtgtgtgg ggaagacggt gacattgcag ggcaacctgg acccctgtgc cttgtatgca 3840
tctgaggtaa cagccagggc ccctctgtgt gtcctgttac tgtgcactcc tgtggcctgt 3900
ggttgtatta ttctgtgtgc acttgttttt aatgtctgtc tgtccttttc ttctcatctg 3960
tacaccataa gccctagaaa gaccggactt tttgttgctg ttgttcattt gtgtttatgc 4020
ttcatgcctg ggtccatact agggatctat aaattttatt gaatgactga ataacactga 4080
gttagaagca tgcctaccat atgcgtttct actagtatat atagggagga caaaggcttg 4140
ctggtcctcc tgtagccagt gccctgttgg tcccccagga ggagatcggg cagttggtga 4200
agcagatgct ggatgacttt ggaccacatc gctacattgc caacttgggc catgggcttt 4260
atcctgacat ggacccagaa catgtgggcg cctttgtgga tgctgtgcat aaacactcac 4320
gtctgcttcg acagaactga ccgtatacct ttaccctcaa gtaccactaa cacagatgat 4380
tgatcgtttc caggacaata aaagtttcgg agttgaacct attgtgtagt tttgtttgtg 4440
aaagattgtc ccatatcctc agttcttctt agcctctgtc tccttccctg ggaccctctc 4500
atatcctctt atag 4514
//