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NiceProt View of Swiss-Prot: Q99611
[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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General information about the entry
Entry name SPS2_HUMAN
Primary accession number Q99611
Secondary accession number Q9BUQ2
Entered in Swiss-Prot in Release 38, July 1999
Sequence was last modified in Release 38, July 1999
Annotations were last modified in    Release 41, February 2003
Name and origin of the protein
Protein name Selenide,water dikinase 2
Synonyms EC 2.7.9.3
Selenophosphate synthetase 2
Selenium donor protein 2
Gene name
SPS2
From
Homo sapiens (Human) [TaxID: 9606]
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1]
 SEQUENCE FROM NUCLEIC ACID.
MEDLINE=96017645; PubMed=7588067; [NCBI, ExPASy, EBI, Israel, Japan]
Guimaraes M.J., Bazan J.F., Zlotnik A., Wiles M.V., Grimaldi J.C., Lee F., McClanahan T.;
"A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies.";
Development 121:3335-3346(1995).
[2]
 SEQUENCE FROM NUCLEIC ACID.
MEDLINE=97140286; PubMed=8986768; [NCBI, ExPASy, EBI, Israel, Japan]
Guimaraes M.J., Peterson D., Vicari A., Cocks B.G., Copeland N.G., Gilbert D.J., Jenkins N.A., Ferrick D.A., Kastelein R., Bazan J.F., Zlotnik A.;
"Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?";
Proc. Natl. Acad. Sci. U.S.A. 93:15086-15091(1996).
[3]
 SEQUENCE FROM NUCLEIC ACID.
TISSUE=Muscle;
Strausberg R.;
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: Synthesizes selenophosphate from selenide and ATP.
  • CATALYTIC ACTIVITY: ATP + selenide + H2O = AMP + selenophosphate + phosphate.
  • COFACTOR: SELENOCYSTEINE. THE ACTIVE-SITE SELENOCYSTEINE IS ENCODED BY THE OPAL CODON, UGA.
  • SIMILARITY: BELONGS TO THE SELENOPHOSPHATE SYNTHETASE 1 FAMILY. CLASS I SUBFAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL
U43286; AAC50958.2; -.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002381; AAH02381.1; ALT_SEQ.[EMBL / GenBank / DDBJ] [CoDingSequence]
MIM 606218 [NCBI / EBI].
GeneCards SPS2.
GeneLynx SPS2; Homo sapiens.
SOURCE SPS2; Homo sapiens.
Ensembl Q99611; Homo sapiens. [Entry / Contig view]
InterPro IPR000728; AIRS_related.
IPR004536; SelD.
Graphical view of domain structure.
Pfam PF00586; AIRS; 1.
PF02769; AIRS_C; 1.
TIGRFAMs TIGR00476; selD; 1.
ProDom [Domain structure / List of seq. sharing at least 1 domain].
BLOCKS Q99611.
ProtoNet Q99611.
ProtoMap Q99611.
PRESAGE Q99611.
DIP Q99611.
ModBase Q99611.
SWISS-2DPAGE Get region on 2D PAGE.
Keywords
Transferase; Selenium; Selenocysteine; ATP-binding.
Features
KeyFrom   To Length Description
ACT_SITE   60    60        POTENTIAL.
SE_CYS   60    60        
SITE   63    63  1     IMPORTANT FOR CATALYTIC ACTIVITY (BY SIMILARITY).
NP_BIND   319   325  7     ATP (POTENTIAL).
SEVIEWER logo Feature table viewer
Sequence information
Length: 448 AA Molecular weight: 47258 Da CRC64: 343A58CD9F842B99 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
         |          |          |          |          |          | 
MAEASATGAC GEAMAAAEGS SGPAGLTLGR SFSNYRPFEP QALGLSPSWR LTGFSGMKGC 

        70         80         90        100        110        120 
         |          |          |          |          |          | 
GCKVPQEALL KLLAGLTRPD VRPPLGRGLV GGQEEASQEA GLPAGAGPSP TFPALGIGMD 

       130        140        150        160        170        180 
         |          |          |          |          |          | 
SCVIPLRHGG LSLVQTTDFF YPLVEDPYMM GRIACANVLS DLYAMGITEC DNMLMLLSVS 

       190        200        210        220        230        240 
         |          |          |          |          |          | 
QSMSEEEREK VTPLMVKGFR DAAEEGGTAV TGGQTVVNPW IIIGGVATVV CQPNEFIMPD 

       250        260        270        280        290        300 
         |          |          |          |          |          | 
SAVVGDVLVL TKPLGTQVAV NAHQWLDNPE RWNKVKMVVS REEVELAYQE AMFNMATLNR 

       310        320        330        340        350        360 
         |          |          |          |          |          | 
TAAGLMHTFN AHAATDITGF GILGHSQNLA KQQRNEVSFV IHNLPIIAKM AAVSKASGRF 

       370        380        390        400        410        420 
         |          |          |          |          |          | 
GLLQGTSAET SGGLLICLPR EQAARFCSEI KSSKYGEGHQ AWIVGIVEKG NRTARIIDKP 

       430        440 
         |          | 
RVIEVLPRGA TAAVLAPDSS NASSEPSS
Q99611 in FASTA format

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