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[1]
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SEQUENCE FROM NUCLEIC ACID, AND SEQUENCE.
TISSUE=Liver;
MEDLINE=86243367; PubMed=3013304; [NCBI, ExPASy, EBI, Israel, Japan]
von Bahr-Lindstrom H.,
Hoeoeg J.-O.,
Heden L.-O.,
Kaiser R.,
Fleetwood L.,
Larsson K.,
Lake M.,
Holmquist B.,
Holmgren A.,
Hempel J.,
Vallee B.L.,
Joernvall H.;
"cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase.";
Biochemistry 25:2465-2470(1986).
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[2]
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SEQUENCE FROM NUCLEIC ACID.
MEDLINE=86120995; PubMed=2935875; [NCBI, ExPASy, EBI, Israel, Japan]
Ikuta T.,
Szeto S.,
Yoshida A.;
"Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.";
Proc. Natl. Acad. Sci. U.S.A. 83:634-638(1986).
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[3]
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SEQUENCE FROM NUCLEIC ACID.
MEDLINE=89153548; PubMed=2920825; [NCBI, ExPASy, EBI, Israel, Japan]
Matsuo Y.,
Yokoyama S.;
"Molecular structure of the human alcohol dehydrogenase 1 gene.";
FEBS Lett. 243:57-60(1989).
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[4]
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SEQUENCE OF 1-5 FROM NUCLEIC ACID.
MEDLINE=90269803; PubMed=2347582; [NCBI, ExPASy, EBI, Israel, Japan]
Yasunami M.,
Kikuchi I.,
Sarapata D.,
Yoshida A.;
"The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.";
Genomics 7:152-158(1990).
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- CATALYTIC ACTIVITY: An alcohol + NAD+ = an aldehyde or ketone + NADH.
- COFACTOR: ZINC.
- SUBUNIT: DIMER OF IDENTICAL OR NONIDENTICAL CHAINS OF THREE TYPES (ALPHA, BETA, GAMMA).
- SUBCELLULAR LOCATION: Cytoplasmic.
- MISCELLANEOUS: THERE ARE 7 DIFFERENT ADH'S ISOZYMES IN HUMAN: THREE BELONGS TO CLASS-I: ALPHA, BETA, AND GAMMA, ONE TO CLASS-II: PI, ONE TO CLASS-III: CHI, ONE TO CLASS-IV: ADH7 AND ONE TO CLASS-V: ADH6.
- SIMILARITY: BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY.
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This SWISS-PROT entry is copyright. It is produced through a collaboration
between the Swiss Institute of Bioinformatics and the EMBL outstation -
the European Bioinformatics Institute. There are no restrictions on its
use by non-profit institutions as long as its content is in no way
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entities requires a license agreement (See http://www.isb-sib.ch/announce/
or send an email to license@isb-sib.ch).
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10 20 30 40 50 60
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STAGKVIKCK AAVLWELKKP FSIEEVEVAP PKAHEVRIKM VAVGICGTDD HVVSGTMVTP
70 80 90 100 110 120
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LPVILGHEAA GIVESVGEGV TTVKPGDKVI PLAIPQCGKC RICKNPESNY CLKNDVSNPQ
130 140 150 160 170 180
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GTLQDGTSRF TCRRKPIHHF LGISTFSQYT VVDENAVAKI DAASPLEKVC LIGCGFSTGY
190 200 210 220 230 240
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GSAVNVAKVT PGSTCAVFGL GGVGLSAIMG CKAAGAARII AVDINKDKFA KAKELGATEC
250 260 270 280 290 300
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INPQDYKKPI QEVLKEMTDG GVDFSFEVIG RLDTMMASLL CCHEACGTSV IVGVPPDSQN
310 320 330 340 350 360
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LSMNPMLLLT GRTWKGAILG GFKSKECVPK LVADFMAKKF SLDALITHVL PFEKINEGFD
370
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LLHSGKSIRT ILMF
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P07327 in FASTA format |
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