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RID=1069694397-9914-17664825597.BLASTQ3, HS307871 BLASTX 2.2.6 [Apr-09-2003]

RID: 1069694397-9914-17664825597.BLASTQ3

Query= HS307871 (4514 letters)

Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 1,544,637 sequences; 504,792,447 total letters Taxonomy reports

Distribution of 564 Blast Hits on the Query Sequence


Related Structures

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|2507533|sp|P06132|DCUP_HUMAN  Uroporphyrinogen decarboxyl...   215   5e-54 LocusLink infoRelated structures
gi|12804699|gb|AAH01778.1|  Uroporphyrinogen decarboxylase [...   215   5e-54 LocusLink info
gi|9845522|ref|NP_000365.2|  uroporphyrinogen decarboxylase;...   215   5e-54 LocusLink info
gi|18158958|pdb|1JPH|A  Chain A, Ile260thr Mutant Of Human U...   215   5e-54 Related structures
gi|18158959|pdb|1JPI|A  Chain A, Phe232leu Mutant Of Human U...   215   5e-54 Related structures
gi|30584783|gb|AAP36644.1|  Homo sapiens uroporphyrinogen de...   215   5e-54 
gi|18158960|pdb|1JPK|A  Chain A, Gly156asp Mutant Of Human U...   213   3e-53 Related structures
gi|88979|pir||A24411  uroporphyrinogen decarboxylase (EC 4.1...   211   1e-52 LocusLink info
gi|340183|gb|AAB59456.1|  uroporphyrinogen decarboxylase          206   3e-51 LocusLink info
gi|27527067|emb|CAC82649.1|  uroporphyrinogen decarboxylase ...   206   4e-51 
gi|14198090|gb|AAH08109.1|  Uroporphyrinogen decarboxylase [...   198   7e-49 LocusLink info
gi|6678517|ref|NP_033504.1|  uroporphyrinogen decarboxylase ...   197   2e-48 LocusLink info
gi|34870275|ref|XP_342888.1|  similar to uroporphyrinogen de...   196   3e-48 LocusLink info
gi|225691|prf||1310344A  decarboxylase,uroporphyrinogen           189   5e-46 
gi|416892|sp|P32362|DCUP_RAT  Uroporphyrinogen decarboxylase...   187   2e-45 LocusLink info
gi|18859531|ref|NP_571422.1|  uroporphyrinogen decarboxylase...   147   2e-33 LocusLink info
gi|19075585|ref|NP_588085.1|  probable uroporphyrinogen deca...   127   2e-27 
gi|4140696|gb|AAD04168.1|  uroporphyrinogen decarboxylase [H...   118   9e-25 
gi|6320252|ref|NP_010332.1|  fifth enzyme in the heme biosyn...   109   4e-22 
gi|31240435|ref|XP_320631.1|  ENSANGP00000021292 [Anopheles ...   109   5e-22 
gi|19921920|ref|NP_610501.1|  CG1818-PA [Drosophila melanoga...   107   2e-21 LocusLink info
gi|21430840|gb|AAM51098.1|  SD19419p [Drosophila melanogaster]    107   2e-21 LocusLink info
gi|4140695|gb|AAD04167.1|  uroporphyrinogen decarboxylase [H...   104   2e-20 LocusLink info
gi|3915203|sp|O18601|DCUP_DROVI  Uroporphyrinogen decarboxyl...   103   4e-20 
gi|32418962|ref|XP_329959.1|  hypothetical protein [Neurospo...   101   1e-19 
gi|38110215|gb|EAA55971.1|  hypothetical protein MG01622.4 [...   101   1e-19 
gi|21674849|ref|NP_662914.1|  uroporphyrinogen decarboxylase...    91   3e-16 
gi|21232275|ref|NP_638192.1|  uroporphyrinogen decarboxylase...    88   1e-15 
gi|21243740|ref|NP_643322.1|  uroporphyrinogen decarboxylase...    87   4e-15 
gi|28872231|ref|NP_794850.1|  uroporphyrinogen decarboxylase...    85   1e-14 
gi|16123871|ref|NP_407184.1|  uroporphyrinogen decarboxylase...    85   1e-14 
gi|33598623|ref|NP_886266.1|  uroporphyrinogen decarboxylase...    84   2e-14 
gi|33603574|ref|NP_891134.1|  uroporphyrinogen decarboxylase...    84   2e-14 
gi|23469744|ref|ZP_00125078.1|  COG0407: Uroporphyrinogen-II...    84   2e-14 
gi|33594189|ref|NP_881833.1|  uroporphyrinogen decarboxylase...    83   5e-14 
gi|23104868|ref|ZP_00091328.1|  COG0407: Uroporphyrinogen-II...    83   5e-14 
gi|22994377|ref|ZP_00038883.1|  COG0407: Uroporphyrinogen-II...    83   5e-14 
gi|23138367|ref|ZP_00120028.1|  COG0407: Uroporphyrinogen-II...    82   7e-14 
gi|15603599|ref|NP_246673.1|  UroD [Pasteurella multocida] >...    82   7e-14 
gi|28899690|ref|NP_799295.1|  uroporphyrinogen decarboxylase...    80   1e-13 
gi|26991750|ref|NP_747175.1|  uroporphyrinogen decarboxylase...    81   2e-13 
gi|409791|gb|AAC43095.1|  uroporphyrinogen decarboxylase           78   2e-13 
gi|34496577|ref|NP_900792.1|  uroporphyrinogen decarboxylase...    81   2e-13 
gi|15792567|ref|NP_282390.1|  uroporphyrinogen decarboxylase...    81   2e-13 
gi|37524498|ref|NP_927842.1|  uroporphyrinogen decarboxylase...    81   2e-13 
gi|28198490|ref|NP_778804.1|  uroporphyrinogen decarboxylase...    81   2e-13 
gi|15640359|ref|NP_229986.1|  uroporphyrinogen decarboxylase...    77   2e-13 
gi|23814028|sp|Q9KV26|DCUP_VIBCH  Uroporphyrinogen decarboxy...    77   2e-13 
gi|15834174|ref|NP_312947.1|  uroporphyrinogen decarboxylase...    78   2e-13 
gi|16131827|ref|NP_418425.1|  uroporphyrinogen decarboxylase...    78   2e-13 
gi|26250768|ref|NP_756808.1|  Uroporphyrinogen decarboxylase...    78   2e-13 
gi|15804588|ref|NP_290629.1|  uroporphyrinogen decarboxylase...    78   2e-13 
gi|24115281|ref|NP_709791.1|  uroporphyrinogen decarboxylase...    78   2e-13 
gi|29653627|ref|NP_819319.1|  uroporphyrinogen decarboxylase...    80   3e-13 
gi|22996471|ref|ZP_00040726.1|  COG0407: Uroporphyrinogen-II...    80   3e-13 
gi|24372030|ref|NP_716072.1|  uroporphyrinogen decarboxylase...    77   3e-13 
gi|16762290|ref|NP_457907.1|  uroporphyrinogen decarboxylase...    77   3e-13 
gi|23058150|ref|ZP_00083245.1|  COG0407: Uroporphyrinogen-II...    80   3e-13 
gi|23028166|ref|ZP_00066577.1|  COG0407: Uroporphyrinogen-II...    77   5e-13 
gi|24461655|gb|AAN62224.1|  putative uroporphyrinogen decarb...    76   6e-13 
gi|15676679|ref|NP_273823.1|  uroporphyrinogen decarboxylase...    79   6e-13 
gi|30248462|ref|NP_840532.1|  Uroporphyrinogen decarboxylase...    77   8e-13 
gi|27364622|ref|NP_760150.1|  Uroporphyrinogen-III decarboxy...    78   1e-12 
gi|15600227|ref|NP_253721.1|  uroporphyrinogen decarboxylase...    79   1e-12 
gi|15837933|ref|NP_298621.1|  uroporphyrinogen decarboxylase...    79   1e-12 
gi|16767421|ref|NP_463036.1|  uroporphyrinogen decarboxylase...    79   1e-12 
gi|32034577|ref|ZP_00134733.1|  COG0407: Uroporphyrinogen-II...    79   1e-12 
gi|1750399|gb|AAB39261.1|  HemE homolog [Pseudomonas aerugin...    79   1e-12 
gi|15793948|ref|NP_283770.1|  putative uroporphyrinogen deca...    77   2e-12 
gi|22980669|ref|ZP_00026372.1|  COG0407: Uroporphyrinogen-II...    77   4e-12 
gi|23000993|ref|ZP_00044909.1|  COG0407: Uroporphyrinogen-II...    77   4e-12 
gi|22984033|ref|ZP_00029193.1|  COG0407: Uroporphyrinogen-II...    76   5e-12 
gi|23468082|ref|ZP_00123649.1|  COG0407: Uroporphyrinogen-II...    62   2e-11 
gi|23054304|ref|ZP_00080471.1|  COG0407: Uroporphyrinogen-II...    73   4e-11 
gi|34556803|ref|NP_906618.1|  UROPORPHYRINOGEN DECARBOXYLASE...    71   2e-10 
gi|22970842|ref|ZP_00017866.1|  hypothetical protein [Chloro...    71   2e-10 
gi|15806153|ref|NP_294857.1|  uroporphyrinogen decarboxylase...    55   2e-09 
gi|216564|dbj|BAA02148.1|  uroporphyrinogen III decarboxylas...    67   2e-09 
gi|38233021|ref|NP_938788.1|  uroporphyrinogen decarboxylase...    67   4e-09 
gi|21224363|ref|NP_630142.1|  uroporphyrinogen decarboxylase...    66   7e-09 
gi|29828770|ref|NP_823404.1|  putative uroporphyrinogen deca...    65   1e-08 
gi|699194|gb|AAA62959.1|  hemE [Mycobacterium leprae]              62   1e-07 
gi|15827506|ref|NP_301769.1|  uroporphyrinogen decarboxylase...    62   1e-07 
gi|8928071|sp|Q9RV96|DCUP_DEIRA  Uroporphyrinogen decarboxyl...    55   1e-07 
gi|23502914|ref|NP_699041.1|  uroporphyrinogen decarboxylase...    53   2e-07 
gi|32267372|ref|NP_861404.1|  uroporphyrinogen decarboxylase...    61   2e-07 
gi|17986285|ref|NP_538919.1|  UROPORPHYRINOGEN DECARBOXYLASE...    53   3e-07 
gi|32475041|ref|NP_868035.1|  uroporphyrinogen III synthase,...    60   3e-07 
gi|15842216|ref|NP_337253.1|  uroporphyrinogen decarboxylase...    59   1e-06 
gi|31793850|ref|NP_856343.1|  PUTATIVE UROPORPHYRINOGEN DECA...    59   1e-06 
gi|15609815|ref|NP_217194.1|  hemE [Mycobacterium tuberculos...    59   1e-06 
gi|23019778|ref|ZP_00059487.1|  COG0407: Uroporphyrinogen-II...    57   4e-06 
gi|33862718|ref|NP_894278.1|  Uroporphyrinogen decarboxylase...    55   9e-06 
gi|15967094|ref|NP_387447.1|  PROBABLE UROPORPHYRINOGEN DECA...    54   2e-05 
gi|23005188|ref|ZP_00048138.1|  COG0407: Uroporphyrinogen-II...    54   3e-05 
gi|33866029|ref|NP_897588.1|  Uroporphyrinogen decarboxylase...    52   1e-04 
gi|1169255|sp|P42503|DCUP_RHOCA  Uroporphyrinogen decarboxyl...    39   1e-04 
gi|231982|sp|P16891|DCUP_SYNP7  Uroporphyrinogen decarboxyla...    52   1e-04 
gi|37523446|ref|NP_926823.1|  uroporphyrinogen decarboxylase...    51   2e-04 
gi|33861140|ref|NP_892701.1|  Uroporphyrinogen decarboxylase...    50   3e-04 
Alignments
>gi|2507533|sp|P06132|DCUP_HUMAN  LocusLink info Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|3660278|pdb|1URO|A  Related structures Chain A, Uroporphyrinogen Decarboxylase
 gi|2905794|gb|AAC03563.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
          Length = 367

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 212

 Score =  137 bits (346), Expect(2) = 7e-40
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 8    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 52.4 bits (124), Expect(2) = 7e-40
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 291  ARECVGKTVTLQGNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|12804699|gb|AAH01778.1|  LocusLink info Uroporphyrinogen decarboxylase [Homo sapiens]
 gi|30582313|gb|AAP35383.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
          Length = 367

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 212

 Score =  137 bits (346), Expect(2) = 7e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 8    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 48.9 bits (115), Expect(2) = 7e-39
 Identities = 22/24 (91%), Positives = 23/24 (95%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQ NLDPCALYASE
Sbjct: 291  ARECVGKTVTLQVNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|9845522|ref|NP_000365.2|  LocusLink info uroporphyrinogen decarboxylase; uroporphyrinogen III decarboxylase
            [Homo sapiens]
 gi|7436550|pir||G02786   uroporphyrinogen decarboxylase - human
 gi|1322019|gb|AAC50482.1|  LocusLink info uroporphyrinogen decarboxylase
 gi|1418944|emb|CAA61540.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151813|gb|AAD04571.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151815|gb|AAD04572.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151817|gb|AAD04573.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151819|gb|AAD04574.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151821|gb|AAD04575.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151823|gb|AAD04576.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151825|gb|AAD04577.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151827|gb|AAD04578.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151829|gb|AAD04579.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151831|gb|AAD04580.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151833|gb|AAD04581.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151835|gb|AAD04582.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151837|gb|AAD04583.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151839|gb|AAD04584.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151841|gb|AAD04585.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151843|gb|AAD04586.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151845|gb|AAD04587.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151847|gb|AAD04588.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151849|gb|AAD04589.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151851|gb|AAD04590.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
 gi|31323304|gb|AAP44118.1|   uroporphyrinogen decarboxylase [Homo sapiens]
          Length = 367

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 212

 Score =  137 bits (346), Expect(2) = 7e-40
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 87.0 bits (214), Expect(3) = 3e-35
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 8    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 3e-35
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 52.4 bits (124), Expect(2) = 7e-40
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 291  ARECVGKTVTLQGNLDPCALYASE 314

 Score = 47.0 bits (110), Expect(3) = 3e-35
 Identities = 23/23 (100%), Positives = 23/23 (100%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRFLLDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFLLDAAIIFSDILVVPQ 92
>gi|18158958|pdb|1JPH|A  Related structures Chain A, Ile260thr Mutant Of Human Urod, Human Uroporphyrinogen Iii
            Decarboxylase
          Length = 388

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 113  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 172

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 173  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 193

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 194  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 233

 Score =  136 bits (342), Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 79/133 (59%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM              
Sbjct: 234  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM-------------- 279

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                   I FAKDGHFALEELAQAGYEV
Sbjct: 280  ---------------------------------------ITFAKDGHFALEELAQAGYEV 300

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 301  VGLDWTVAPKKAR 313

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 330  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 388

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 29   PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 65

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 66   EFRETRAAQDFFSTCRSPEACCELTLQ 92

 Score = 52.4 bits (124), Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 312  ARECVGKTVTLQGNLDPCALYASE 335

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 91   LQPLRRFPLDAAIIFSDILVVPQ 113
>gi|18158959|pdb|1JPI|A  Related structures Chain A, Phe232leu Mutant Of Human Urod, Human Uroporphyrinogen Iii
            Decarboxylase
          Length = 388

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 113  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 172

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 173  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 193

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 194  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 233

 Score =  135 bits (340), Expect(2) = 3e-39
 Identities = 78/133 (58%), Positives = 79/133 (59%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNK ALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 234  ALQLFESHAGHLGPQLFNKLALPYIRDVAKQVKARLREAGLAPVPMI------------- 280

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 281  ----------------------------------------IFAKDGHFALEELAQAGYEV 300

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 301  VGLDWTVAPKKAR 313

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 330  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 388

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 29   PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 65

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 66   EFRETRAAQDFFSTCRSPEACCELTLQ 92

 Score = 52.4 bits (124), Expect(2) = 3e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 312  ARECVGKTVTLQGNLDPCALYASE 335

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 91   LQPLRRFPLDAAIIFSDILVVPQ 113
>gi|30584783|gb|AAP36644.1|   Homo sapiens uroporphyrinogen decarboxylase [synthetic construct]
          Length = 368

 Score =  215 bits (548), Expect = 5e-54
 Identities = 119/160 (74%), Positives = 120/160 (75%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 212

 Score =  137 bits (346), Expect(2) = 7e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 8    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 48.9 bits (115), Expect(2) = 7e-39
 Identities = 22/24 (91%), Positives = 23/24 (95%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQ NLDPCALYASE
Sbjct: 291  ARECVGKTVTLQVNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|18158960|pdb|1JPK|A  Related structures Chain A, Gly156asp Mutant Of Human Urod, Human Uroporphyrinogen Iii
            Decarboxylase
          Length = 388

 Score =  213 bits (541), Expect = 3e-53
 Identities = 118/160 (73%), Positives = 119/160 (74%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 113  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 172

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFA AP               W +                        MTYMVEGGGSS
Sbjct: 173  IGFADAP---------------WTL------------------------MTYMVEGGGSS 193

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 194  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 233

 Score =  137 bits (346), Expect(2) = 7e-40
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 234  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 280

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 281  ----------------------------------------IFAKDGHFALEELAQAGYEV 300

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 301  VGLDWTVAPKKAR 313

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 330  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 388

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 29   PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 65

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 66   EFRETRAAQDFFSTCRSPEACCELTLQ 92

 Score = 52.4 bits (124), Expect(2) = 7e-40
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 312  ARECVGKTVTLQGNLDPCALYASE 335

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 91   LQPLRRFPLDAAIIFSDILVVPQ 113
>gi|88979|pir||A24411   uroporphyrinogen decarboxylase (EC 4.1.1.37) - human
 gi|340181|gb|AAA61258.1|  LocusLink info uroporphyrinogen decarboxylase (EC 4.1.1.37)
          Length = 367

 Score =  211 bits (536), Expect = 1e-52
 Identities = 117/160 (73%), Positives = 118/160 (73%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVP KGPSFPEPLREEQDLE LRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPSKGPSFPEPLREEQDLEALRDPEVVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 212

 Score =  137 bits (346), Expect(2) = 7e-40
 Identities = 79/133 (59%), Positives = 80/133 (60%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 87.0 bits (214), Expect(3) = 2e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 8    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 2e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 52.4 bits (124), Expect(2) = 7e-40
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 291  ARECVGKTVTLQGNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 2e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|340183|gb|AAB59456.1|  LocusLink info uroporphyrinogen decarboxylase
          Length = 161

 Score =  206 bits (524), Expect = 3e-51
 Identities = 114/158 (72%), Positives = 116/158 (73%)
 Frame = +1

Query: 2440 GMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF 2619
            GMEVTMVP KGPSFPEPLREEQDLE LRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF
Sbjct: 1    GMEVTMVPSKGPSFPEPLREEQDLEALRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF 60

Query: 2620 AGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSSTMA 2799
            AGAP               W +                        MTYMVEGGGSSTMA
Sbjct: 61   AGAP---------------WTL------------------------MTYMVEGGGSSTMA 81

Query: 2800 QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ+
Sbjct: 82   QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQL 119

 Score = 92.0 bits (227), Expect = 9e-17
 Identities = 44/44 (100%), Positives = 44/44 (100%)
 Frame = +3

Query: 3285 QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM 3416
            QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM
Sbjct: 118  QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM 161
>gi|27527067|emb|CAC82649.1|   uroporphyrinogen decarboxylase [Ovis aries]
          Length = 367

 Score =  206 bits (523), Expect = 4e-51
 Identities = 113/160 (70%), Positives = 117/160 (73%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREERDLERLRDPATVASELGYVFQAITLTRQQLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGGGSS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGGSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct: 173  TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ 212

 Score =  127 bits (319), Expect(2) = 2e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAP+KAR
Sbjct: 280  VGLDWTVAPEKAR 292

 Score =  110 bits (275), Expect = 2e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 367

 Score = 89.4 bits (220), Expect(3) = 4e-35
 Identities = 38/39 (97%), Positives = 39/39 (100%)
 Frame = +3

Query: 1743 ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 6    SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 4e-35
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 47.8 bits (112), Expect(2) = 2e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGKTVTLQGNLDPCALYASE
Sbjct: 291  ARERVGKTVTLQGNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 4e-35
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|14198090|gb|AAH08109.1|  LocusLink info Uroporphyrinogen decarboxylase [Mus musculus]
          Length = 367

 Score =  198 bits (504), Expect = 7e-49
 Identities = 109/160 (68%), Positives = 113/160 (70%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP   ASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGG SS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGSSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASH+LL ILTD LVPYL+GQV AGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQ 212

 Score =  124 bits (311), Expect(2) = 6e-34
 Identities = 72/133 (54%), Positives = 78/133 (58%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  109 bits (272), Expect = 5e-22
 Identities = 51/59 (86%), Positives = 54/59 (91%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QMLDDFGP RYIANLGHGLYPDMDPE VGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGRLVQQMLDDFGPQRYIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN 367

 Score = 82.0 bits (201), Expect(3) = 6e-33
 Identities = 35/36 (97%), Positives = 35/36 (97%)
 Frame = +3

Query: 1752 QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 9    QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 6e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 45.8 bits (107), Expect(2) = 6e-34
 Identities = 21/24 (87%), Positives = 22/24 (91%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGK VTLQGNLDPCALYASE
Sbjct: 291  ARERVGKAVTLQGNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 6e-33
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|6678517|ref|NP_033504.1|  LocusLink info uroporphyrinogen decarboxylase [Mus musculus]
 gi|2501645|sp|P70697|DCUP_MOUSE  LocusLink info Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|7436557|pir||T10088   uroporphyrinogen decarboxylase (EC 4.1.1.37) - mouse
 gi|1498643|gb|AAB18294.1|  LocusLink info uroporphyrinogen decarboxylase
          Length = 367

 Score =  197 bits (500), Expect = 2e-48
 Identities = 108/160 (67%), Positives = 113/160 (70%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALG+EVTMVPGKGPSFPEPLREE+DLERLRDP   ASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALGIEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGG SS
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGSSS 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQRPQASH+LL ILTD LVPYL+GQV AGAQ
Sbjct: 173  TMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQ 212

 Score =  124 bits (311), Expect(2) = 6e-34
 Identities = 72/133 (54%), Positives = 78/133 (58%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct: 213  ALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  105 bits (263), Expect = 6e-21
 Identities = 50/59 (84%), Positives = 53/59 (89%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QMLDDFGP R IANLGHGLYPDMDPE VGAFVDAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGRLVQQMLDDFGPQRSIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN 367

 Score = 82.0 bits (201), Expect(3) = 6e-33
 Identities = 35/36 (97%), Positives = 35/36 (97%)
 Frame = +3

Query: 1752 QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 9    QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 6e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 45.8 bits (107), Expect(2) = 6e-34
 Identities = 21/24 (87%), Positives = 22/24 (91%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGK VTLQGNLDPCALYASE
Sbjct: 291  ARERVGKAVTLQGNLDPCALYASE 314

 Score = 44.3 bits (103), Expect(3) = 6e-33
 Identities = 22/23 (95%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPLRRFPLDAAIIFSDILVVPQ 92
>gi|34870275|ref|XP_342888.1|  LocusLink info similar to uroporphyrinogen decarboxylase [Rattus norvegicus]
          Length = 374

 Score =  196 bits (498), Expect = 3e-48
 Identities = 108/160 (67%), Positives = 114/160 (71%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct: 99   QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPL 158

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGG SS
Sbjct: 159  IGFAGAP---------------WTL------------------------MTYMVEGGSSS 179

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQ+P ASH+LL ILTDALVPYL+GQV AGAQ
Sbjct: 180  TMAQAKRWLYQKPLASHKLLGILTDALVPYLIGQVAAGAQ 219

 Score =  124 bits (311), Expect(2) = 2e-34
 Identities = 72/133 (54%), Positives = 78/133 (58%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct: 220  ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI------------- 266

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 267  ----------------------------------------IFAKDGHFALEELAQAGYEV 286

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 287  VGLDWTVAPKKAR 299

 Score =  110 bits (275), Expect = 2e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 316  ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 374

 Score = 85.5 bits (210), Expect(3) = 1e-33
 Identities = 38/41 (92%), Positives = 38/41 (92%)
 Frame = +3

Query: 1737 LIARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LI R Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 11   LIRRLQNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 51

 Score = 60.8 bits (146), Expect(3) = 1e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 52   EFRETRAAQDFFSTCRSPEACCELTLQ 78

 Score = 47.8 bits (112), Expect(2) = 2e-34
 Identities = 22/24 (91%), Positives = 23/24 (95%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGKTVTLQGNLDPCALYASE
Sbjct: 298  ARERVGKTVTLQGNLDPCALYASE 321

 Score = 43.1 bits (100), Expect(3) = 1e-33
 Identities = 21/23 (91%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLR+F LDAAIIFSDILVVPQ
Sbjct: 77   LQPLRKFPLDAAIIFSDILVVPQ 99
>gi|225691|prf||1310344A   decarboxylase,uroporphyrinogen
          Length = 367

 Score =  189 bits (479), Expect = 5e-46
 Identities = 105/160 (65%), Positives = 110/160 (68%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QAL MEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct: 92   QALAMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL 151

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGG   
Sbjct: 152  IGFAGAP---------------WTL------------------------MTYMVEGGSFK 172

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQ+P ASH+LL ILT ALVPYL+GQV AGAQ
Sbjct: 173  TMAQAKRWLYQKPVASHKLLGILTHALVPYLIGQVAAGAQ 212

 Score =  118 bits (295), Expect(2) = 5e-32
 Identities = 69/133 (51%), Positives = 76/133 (57%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGL  +PM+             
Sbjct: 213  ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLTRMPMI------------- 259

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 260  ----------------------------------------IFAKDGHFALEELAQAGYEV 279

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 280  VGLDWTVAPKKAR 292

 Score =  109 bits (272), Expect = 5e-22
 Identities = 50/59 (84%), Positives = 55/59 (93%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAF+DAVHKHSRLLRQN
Sbjct: 309  ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFLDAVHKHSRLLRQN 367

 Score = 77.0 bits (188), Expect(3) = 4e-31
 Identities = 34/36 (94%), Positives = 34/36 (94%)
 Frame = +3

Query: 1752 QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            Q FPELKNDTFLRAA GEETDYTPVWCMRQAGRYLP
Sbjct: 9    QNFPELKNDTFLRAATGEETDYTPVWCMRQAGRYLP 44

 Score = 60.8 bits (146), Expect(3) = 4e-31
 Identities = 27/27 (100%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct: 45   EFRETRAAQDFFSTCRSPEACCELTLQ 71

 Score = 45.4 bits (106), Expect(2) = 5e-32
 Identities = 21/24 (87%), Positives = 22/24 (91%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGKTVTLQG LDPCALYASE
Sbjct: 291  AREPVGKTVTLQGELDPCALYASE 314

 Score = 43.1 bits (100), Expect(3) = 4e-31
 Identities = 21/23 (91%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQP+RRF LDAAIIFSDILVVPQ
Sbjct: 70   LQPVRRFPLDAAIIFSDILVVPQ 92
>gi|416892|sp|P32362|DCUP_RAT   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|5524747|emb|CAB50784.1|  LocusLink info uroporphyrinogen decarboxylase [Rattus norvegicus]
          Length = 364

 Score =  187 bits (475), Expect = 2e-45
 Identities = 104/160 (65%), Positives = 110/160 (68%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QAL MEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct: 89   QALAMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPL 148

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP               W +                        MTYMVEGG   
Sbjct: 149  IGFAGAP---------------WTL------------------------MTYMVEGGSFK 169

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            TMAQAKRWLYQ+P ASH+LL ILT ALVPYL+GQV AGAQ
Sbjct: 170  TMAQAKRWLYQKPVASHKLLGILTHALVPYLIGQVAAGAQ 209

 Score =  118 bits (295), Expect(2) = 5e-32
 Identities = 69/133 (51%), Positives = 76/133 (57%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGL  +PM+             
Sbjct: 210  ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLTRMPMI------------- 256

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    IFAKDGHFALEELAQAGYEV
Sbjct: 257  ----------------------------------------IFAKDGHFALEELAQAGYEV 276

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWTVAPKKAR
Sbjct: 277  VGLDWTVAPKKAR 289

 Score =  109 bits (272), Expect = 5e-22
 Identities = 50/59 (84%), Positives = 55/59 (93%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAF+DAVHKHSRLLRQN
Sbjct: 306  ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFLDAVHKHSRLLRQN 364

 Score = 82.0 bits (201), Expect(3) = 7e-32
 Identities = 35/36 (97%), Positives = 35/36 (97%)
 Frame = +3

Query: 1752 QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct: 6    QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 41

 Score = 59.7 bits (143), Expect(3) = 7e-32
 Identities = 26/27 (96%), Positives = 27/27 (100%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRETRAAQDFFSTCRSPEACCELTL+
Sbjct: 42   EFRETRAAQDFFSTCRSPEACCELTLE 68

 Score = 45.4 bits (106), Expect(2) = 5e-32
 Identities = 21/24 (87%), Positives = 22/24 (91%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RE VGKTVTLQG LDPCALYASE
Sbjct: 288  AREPVGKTVTLQGELDPCALYASE 311

 Score = 42.0 bits (97), Expect(3) = 7e-32
 Identities = 20/23 (86%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            L+P+RRF LDAAIIFSDILVVPQ
Sbjct: 67   LEPVRRFPLDAAIIFSDILVVPQ 89
>gi|18859531|ref|NP_571422.1|  LocusLink info uroporphyrinogen decarboxylase [Danio rerio]
 gi|20138048|sp|Q9PTS2|DCUP_BRARE  LocusLink info Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|6502530|gb|AAF14346.1|  LocusLink info uroporphyrinogen decarboxylase [Danio rerio]
          Length = 369

 Score =  147 bits (370), Expect = 2e-33
 Identities = 80/160 (50%), Positives = 101/160 (63%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QA+GMEV M PGKGP+FPEPL+E +DL+RL+    V SEL YVF+AITLTR ++ G+VPL
Sbjct: 94   QAMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPL 153

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGF GAP               W +                        M+YM+EGGGS+
Sbjct: 154  IGFTGAP---------------WTL------------------------MSYMIEGGGSA 174

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            T ++AKRWLY+ P+ASH+LL  LTD +V YL+GQV AGAQ
Sbjct: 175  THSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQ 214

 Score = 88.6 bits (218), Expect(2) = 3e-19
 Identities = 48/133 (36%), Positives = 68/133 (51%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS 3458
            ALQ+FESH G LGP  F +F+LPY+RD+A++VK +++E+GL  VPM+             
Sbjct: 215  ALQVFESHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGLDNVPMI------------- 261

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                    +FAKDGH+ LE+L+++ YEV
Sbjct: 262  ----------------------------------------VFAKDGHYGLEDLSESAYEV 281

Query: 3639 VGLDWTVAPKKAR 3677
            VGLDWT+ P+ AR
Sbjct: 282  VGLDWTIDPRSAR 294

 Score = 80.5 bits (197), Expect = 3e-13
 Identities = 40/68 (58%), Positives = 48/68 (70%)
 Frame = +3

Query: 4125 GGQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDA 4304
            G   L G     AL   +E I ++V++ML+ FG   YIANLGHGLYPDMDPE+VGAFV+A
Sbjct: 299  GKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEA 358

Query: 4305 VHKHSRLL 4328
            VH HSR L
Sbjct: 359  VHNHSRQL 366

 Score = 68.2 bits (165), Expect(3) = 1e-26
 Identities = 29/37 (78%), Positives = 33/37 (89%)
 Frame = +3

Query: 1749 PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            P+ FPEL+NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct: 10   PKDFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLP 46

 Score = 54.7 bits (130), Expect(3) = 1e-26
 Identities = 23/27 (85%), Positives = 25/27 (92%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EFRE+RA +DFF TCRSPEACCELTLQ
Sbjct: 47   EFRESRAGKDFFETCRSPEACCELTLQ 73

 Score = 42.7 bits (99), Expect(3) = 1e-26
 Identities = 21/23 (91%), Positives = 21/23 (91%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            LQPLRRF  DAAIIFSDILVVPQ
Sbjct: 72   LQPLRRFPFDAAIIFSDILVVPQ 94

 Score = 32.3 bits (72), Expect(2) = 3e-19
 Identities = 13/25 (52%), Positives = 19/25 (76%)
 Frame = +1

Query: 3772 ASRECVGKTVTLQGNLDPCALYASE 3846
            ++R   G  V+LQGN+DPCALY ++
Sbjct: 292  SARVRTGGKVSLQGNMDPCALYGTK 316
>gi|19075585|ref|NP_588085.1|   probable uroporphyrinogen decarboxylase [Schizosaccharomyces pombe]
 gi|8928074|sp|Q9USJ5|DCUP_SCHPO   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|11267829|pir||T50443   probable uroporphyrinogen decarboxylase [imported] - fission yeast
            (Schizosaccharomyces pombe)
 gi|6434013|emb|CAB60679.1|   SPCC4B3.05c [Schizosaccharomyces pombe]
          Length = 370

 Score =  127 bits (319), Expect = 2e-27
 Identities = 69/161 (42%), Positives = 96/161 (59%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALGM+V M+  KGP FP+PL   +D++ L     ++++LGYV  AI+LTR++L G+VPL
Sbjct: 96   QALGMQVVMLEQKGPHFPKPLVVPEDIDLLEKTPNISAKLGYVMDAISLTREKLDGQVPL 155

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            +GF+GAP               W +                        M YM+EGGGS 
Sbjct: 156  MGFSGAP---------------WTI------------------------MAYMIEGGGSK 176

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            T A+AK WL++ P+ASH+LL+I+TDA V YL+ QV AGAQ+
Sbjct: 177  TFAKAKSWLFRYPEASHKLLKIITDATVSYLIQQVYAGAQL 217

 Score = 59.3 bits (142), Expect(2) = 2e-08
 Identities = 36/131 (27%), Positives = 57/131 (43%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF 3461
            LQ+F+S AG L P+ F ++A PY+  + ++VK  L++     VPM               
Sbjct: 218  LQIFDSWAGELSPEDFTEYAYPYLVRICQEVKQHLKKKKRDEVPM--------------- 262

Query: 3462 QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV 3641
                                                  I+FAK   +A+++L  +GY+V+
Sbjct: 263  --------------------------------------IVFAKGAWYAIDQLCDSGYDVI 284

Query: 3642 GLDWTVAPKKA 3674
            GLDWTV+PK+A
Sbjct: 285  GLDWTVSPKEA 295

 Score = 40.4 bits (93), Expect = 0.30
 Identities = 19/49 (38%), Positives = 31/49 (63%), Gaps = 2/49 (4%)
 Frame = +3

Query: 4176 QEEIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVHKH 4316
            +E I    K+M+ DFG  +  YI NLGHG+ P ++P+ V  F++  H++
Sbjct: 319  REIIEARTKEMIQDFGGGKQGYIINLGHGITPGVNPDDVRFFLEKCHQY 367

 Score = 38.1 bits (87), Expect(2) = 4e-06
 Identities = 20/25 (80%), Positives = 22/25 (88%), Gaps = 2/25 (8%)
 Frame = +2

Query: 2126 LQPLRRF--LLDAAIIFSDILVVPQ 2194
            LQP+ RF  LLDAAIIFSDILV+PQ
Sbjct: 72   LQPVTRFKGLLDAAIIFSDILVIPQ 96

 Score = 38.1 bits (87), Expect(2) = 4e-06
 Identities = 15/27 (55%), Positives = 19/27 (70%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            E+ + RA Q FF  C++PE  CELTLQ
Sbjct: 47   EYHKLRAKQSFFEMCQTPETACELTLQ 73

 Score = 24.6 bits (52), Expect(2) = 2e-08
 Identities = 10/17 (58%), Positives = 12/17 (70%)
 Frame = +1

Query: 3793 KTVTLQGNLDPCALYAS 3843
            + VT QGNLDP  LY +
Sbjct: 302  RRVTFQGNLDPNILYGT 318
>gi|4140696|gb|AAD04168.1|   uroporphyrinogen decarboxylase [Homo sapiens]
          Length = 109

 Score =  118 bits (296), Expect = 9e-25
 Identities = 55/59 (93%), Positives = 56/59 (94%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 4337
            AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct: 51   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN 109

 Score = 72.4 bits (176), Expect(2) = 2e-20
 Identities = 34/34 (100%), Positives = 34/34 (100%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR
Sbjct: 1    IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 34

 Score = 52.4 bits (124), Expect(2) = 2e-20
 Identities = 23/24 (95%), Positives = 24/24 (100%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASE 3846
            +RECVGKTVTLQGNLDPCALYASE
Sbjct: 33   ARECVGKTVTLQGNLDPCALYASE 56
>gi|6320252|ref|NP_010332.1|   fifth enzyme in the heme biosynthetic pathway; Hem12p [Saccharomyces
            cerevisiae]
 gi|416894|sp|P32347|DCUP_YEAST   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|283290|pir||S23471   uroporphyrinogen decarboxylase (EC 4.1.1.37) - yeast  (Saccharomyces
            cerevisiae)
 gi|3767|emb|CAA45253.1|   uroporphyrinogen decarboxylase [Saccharomyces cerevisiae]
 gi|4776|emb|CAA79514.1|   uroporphyrinogen decarboxylase [Saccharomyces cerevisiae]
 gi|798900|emb|CAA89078.1|   Hem12p [Saccharomyces cerevisiae]
          Length = 362

 Score =  109 bits (273), Expect = 4e-22
 Identities = 66/162 (40%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEV-VASELGYVFQAITLTRQRLAGRVP 2607
            QA+GM V M+ GKGP FPEPLR  +DL+ + D +V V  EL + F+AIT+TR +L G VP
Sbjct: 87   QAMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDVLKELDWAFKAITMTRIKLDGEVP 146

Query: 2608 LIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGS 2787
            L GF G P               W +                        M YM EGGGS
Sbjct: 147  LFGFCGGP---------------WTL------------------------MVYMTEGGGS 167

Query: 2788 STMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
                 AK+W+   P+ SH+LL+ +TD  V +L  QVVAGAQ+
Sbjct: 168  RLFRFAKQWINMYPELSHKLLQKITDVAVEFLSQQVVAGAQI 209

 Score = 51.2 bits (121), Expect = 2e-04
 Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP-VPMVRIGMG*VKVVLWS 3458
            LQ+FES  G L    F++F+LPY+R +A++V  RL+E G+   +PM              
Sbjct: 210  LQVFESWGGELSSVDFDEFSLPYLRQIAERVPKRLQELGIMEQIPM-------------- 255

Query: 3459 FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV 3638
                                                   I+FAK   +AL++L  +G++V
Sbjct: 256  ---------------------------------------IVFAKGSWYALDKLCCSGFDV 276

Query: 3639 VGLDWTVAPKKA 3674
            V LDW+  P++A
Sbjct: 277  VSLDWSWDPREA 288

 Score = 48.5 bits (114), Expect = 0.001
 Identities = 22/34 (64%), Positives = 24/34 (70%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            FP  KND  LRAA GE+ +  P W MRQAGRYLP
Sbjct: 4    FPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLP 37

 Score = 44.3 bits (103), Expect = 0.021
 Identities = 21/48 (43%), Positives = 31/48 (64%), Gaps = 2/48 (4%)
 Frame = +3

Query: 4176 QEEIGQLVKQMLDDFG--PHRYIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            +E I + VKQM++ FG    RYI N GHG +P MDP+ +  F++  H+
Sbjct: 311  KEVITKKVKQMIEAFGGGKSRYIVNFGHGTHPFMDPDVIKFFLEECHR 358

 Score = 37.7 bits (86), Expect(2) = 2e-04
 Identities = 18/25 (72%), Positives = 23/25 (92%), Gaps = 2/25 (8%)
 Frame = +2

Query: 2126 LQPLRRF--LLDAAIIFSDILVVPQ 2194
            +QP+RR+  L+DAAIIFSDILV+PQ
Sbjct: 63   IQPVRRYRGLIDAAIIFSDILVIPQ 87

 Score = 32.3 bits (72), Expect(2) = 2e-04
 Identities = 23/62 (37%), Positives = 30/62 (48%), Gaps = 1/62 (1%)
 Frame = +1

Query: 1900 GEKFSRGRGGLWR-ASRLSPVFPLYAEFRETRAAQDFFSTCRSPEACCELTLQVRGPQKR 2076
            GEK  R    + R A R  P      E+ E +  +DFF TCR  E   E+T+Q   P +R
Sbjct: 18   GEKVERPPCWIMRQAGRYLP------EYHEVKNNRDFFQTCRDAEIASEITIQ---PVRR 68

Query: 2077 ER 2082
             R
Sbjct: 69   YR 70
>gi|31240435|ref|XP_320631.1|   ENSANGP00000021292 [Anopheles gambiae]
 gi|30174144|gb|EAA00166.2|   ENSANGP00000021292 [Anopheles gambiae str. PEST]
          Length = 351

 Score =  109 bits (272), Expect = 5e-22
 Identities = 69/161 (42%), Positives = 84/161 (52%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALG+ V M PG GP  PEPL    DL+RL     +   L YV +AIT+ R+ L G+VPL
Sbjct: 83   QALGITVEMKPGVGPVLPEPLVGPADLDRLNQTGTI-ERLKYVGEAITMMRRMLEGKVPL 141

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
             GF GAP               W + G                        YM+EGGGS 
Sbjct: 142  FGFTGAP---------------WTLMG------------------------YMIEGGGSK 162

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            TM++AK WL   P+AS +LL ILTD +V YLV QV AGAQ+
Sbjct: 163  TMSKAKGWLADHPEASQKLLDILTDQVVDYLVMQVKAGAQM 203

 Score = 54.7 bits (130), Expect(3) = 1e-18
 Identities = 25/34 (73%), Positives = 25/34 (73%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            FP LKND  LRAA GE  D  PVW MRQAGRYLP
Sbjct: 2    FPPLKNDNLLRAARGEPVDRVPVWVMRQAGRYLP 35

 Score = 54.3 bits (129), Expect(2) = 3e-08
 Identities = 36/132 (27%), Positives = 54/132 (40%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF 3461
            LQ+FES A HL  + F   +LP ++ +   +  +L + G+  VPM               
Sbjct: 204  LQVFESSADHLSKEQFLSVSLPCLKRIRVDLLRKLADEGVPAVPM--------------- 248

Query: 3462 QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV 3641
                                                  ++FAK    +LEE+AQ GYEV+
Sbjct: 249  --------------------------------------VLFAKGAMHSLEEMAQTGYEVL 270

Query: 3642 GLDWTVAPKKAR 3677
            GLDWT+ P++AR
Sbjct: 271  GLDWTIDPEEAR 282

 Score = 51.6 bits (122), Expect = 1e-04
 Identities = 24/46 (52%), Positives = 29/46 (63%)
 Frame = +3

Query: 4173 PQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVH 4310
            P EE+ +LV  M+  FG HRYIANLGHG+ P    E +   V AVH
Sbjct: 303  PPEELRELVLTMVRKFGKHRYIANLGHGITPQTPIESMSVLVQAVH 348

 Score = 42.0 bits (97), Expect(3) = 1e-18
 Identities = 16/27 (59%), Positives = 21/27 (77%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EF+E RA  DFF+ CR+PE  CE+T+Q
Sbjct: 36   EFQEVRAKHDFFTVCRTPELACEVTMQ 62

 Score = 41.6 bits (96), Expect(3) = 1e-18
 Identities = 19/23 (82%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            +QPLRRF LDA+IIFSDILV+PQ
Sbjct: 61   MQPLRRFDLDASIIFSDILVIPQ 83

 Score = 29.3 bits (64), Expect(2) = 3e-08
 Identities = 13/21 (61%), Positives = 16/21 (76%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALY 3837
            +R+ VG  VTLQGNLDP  +Y
Sbjct: 281  ARKRVGPNVTLQGNLDPQDMY 301
>gi|19921920|ref|NP_610501.1|  LocusLink info CG1818-PA [Drosophila melanogaster]
 gi|8928075|sp|Q9V595|DCUP_DROME   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|7303877|gb|AAF58922.1|  LocusLink info CG1818-PA [Drosophila melanogaster]
          Length = 356

 Score =  107 bits (267), Expect = 2e-21
 Identities = 67/161 (41%), Positives = 84/161 (52%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALG+ V M  G GP  P+P+   +DL+RL  P+   S L YV  AIT+ R +L GRVPL
Sbjct: 88   QALGLTVEMHAGVGPVLPQPIVVPEDLKRLT-PDGALSRLSYVGDAITMMRHKLEGRVPL 146

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGF GAP               W + G                        YM+EGGGS 
Sbjct: 147  IGFTGAP---------------WTLMG------------------------YMIEGGGSK 167

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            TM++AK WL + P+ S   L +LTDA+V YL  QV AGAQ+
Sbjct: 168  TMSKAKAWLNEHPEDSKLFLNLLTDAIVDYLEMQVKAGAQM 208

 Score = 53.9 bits (128), Expect(3) = 1e-17
 Identities = 25/34 (73%), Positives = 25/34 (73%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            FP LKND  LRAA GE  D  PVW MRQAGRYLP
Sbjct: 7    FPVLKNDNLLRAARGEVVDRVPVWVMRQAGRYLP 40

 Score = 48.1 bits (113), Expect(2) = 2e-06
 Identities = 33/132 (25%), Positives = 53/132 (40%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF 3461
            LQ+FES A HL  + F ++ +PY++ +  ++  RL +  +  VPM               
Sbjct: 209  LQVFESSAEHLSKEQFLQWCVPYLKRIRDELVDRLTKKAIPVVPMT-------------- 254

Query: 3462 QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV 3641
                                                   +FAK    +L+E ++ GY+V+
Sbjct: 255  ---------------------------------------LFAKGAGHSLKEQSELGYDVI 275

Query: 3642 GLDWTVAPKKAR 3677
            GLDWTV P +AR
Sbjct: 276  GLDWTVDPLEAR 287

 Score = 43.9 bits (102), Expect = 0.027
 Identities = 20/45 (44%), Positives = 27/45 (60%)
 Frame = +3

Query: 4179 EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            +E+  L  +M+  FG  RYIANLGHG+ P      +   V+AVHK
Sbjct: 310  DELRNLTTEMVHKFGKSRYIANLGHGITPQTPITSMEVLVEAVHK 354

 Score = 41.6 bits (96), Expect(3) = 1e-17
 Identities = 19/23 (82%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            +QPLRRF LDA+IIFSDILV+PQ
Sbjct: 66   MQPLRRFDLDASIIFSDILVIPQ 88

 Score = 39.3 bits (90), Expect(3) = 1e-17
 Identities = 15/27 (55%), Positives = 20/27 (74%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EF+E R   DFF+ CR+PE  CE+T+Q
Sbjct: 41   EFQELRKHHDFFTVCRTPELACEVTMQ 67

 Score = 29.3 bits (64), Expect(2) = 2e-06
 Identities = 12/21 (57%), Positives = 15/21 (71%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALY 3837
            +R  VG  +TLQGNLDP  +Y
Sbjct: 286  ARNLVGPNITLQGNLDPQDMY 306
>gi|21430840|gb|AAM51098.1|  LocusLink info SD19419p [Drosophila melanogaster]
          Length = 356

 Score =  107 bits (267), Expect = 2e-21
 Identities = 67/161 (41%), Positives = 84/161 (52%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALG+ V M  G GP  P+P+   +DL+RL  P+   S L YV  AIT+ R +L GRVPL
Sbjct: 88   QALGLTVEMHAGVGPVLPQPIVVPEDLKRLT-PDGALSRLSYVGDAITMMRHKLEGRVPL 146

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGF GAP               W + G                        YM+EGGGS 
Sbjct: 147  IGFTGAP---------------WTLMG------------------------YMIEGGGSK 167

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            TM++AK WL + P+ S   L +LTDA+V YL  QV AGAQ+
Sbjct: 168  TMSKAKAWLNEHPEDSKLFLNLLTDAIVDYLEMQVKAGAQM 208

 Score = 53.9 bits (128), Expect(3) = 1e-17
 Identities = 25/34 (73%), Positives = 25/34 (73%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            FP LKND  LRAA GE  D  PVW MRQAGRYLP
Sbjct: 7    FPVLKNDNLLRAARGEVVDRVPVWVMRQAGRYLP 40

 Score = 46.6 bits (109), Expect(2) = 5e-06
 Identities = 32/132 (24%), Positives = 53/132 (40%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF 3461
            LQ+FES A HL  + F ++ +PY++ +  ++  RL +  +  VP+               
Sbjct: 209  LQVFESSAEHLSKEQFLQWCVPYLKRIRDELVDRLTKKAIPVVPIT-------------- 254

Query: 3462 QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV 3641
                                                   +FAK    +L+E ++ GY+V+
Sbjct: 255  ---------------------------------------LFAKGAGHSLKEQSELGYDVI 275

Query: 3642 GLDWTVAPKKAR 3677
            GLDWTV P +AR
Sbjct: 276  GLDWTVDPLEAR 287

 Score = 43.9 bits (102), Expect = 0.027
 Identities = 20/45 (44%), Positives = 27/45 (60%)
 Frame = +3

Query: 4179 EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            +E+  L  +M+  FG  RYIANLGHG+ P      +   V+AVHK
Sbjct: 310  DELRNLTTEMVHKFGKSRYIANLGHGITPQTPITSMEVLVEAVHK 354

 Score = 41.6 bits (96), Expect(3) = 1e-17
 Identities = 19/23 (82%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            +QPLRRF LDA+IIFSDILV+PQ
Sbjct: 66   MQPLRRFDLDASIIFSDILVIPQ 88

 Score = 39.3 bits (90), Expect(3) = 1e-17
 Identities = 15/27 (55%), Positives = 20/27 (74%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            EF+E R   DFF+ CR+PE  CE+T+Q
Sbjct: 41   EFQELRKHHDFFTVCRTPELACEVTMQ 67

 Score = 29.3 bits (64), Expect(2) = 5e-06
 Identities = 12/21 (57%), Positives = 15/21 (71%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALY 3837
            +R  VG  +TLQGNLDP  +Y
Sbjct: 286  ARNLVGPNITLQGNLDPQDMY 306
>gi|4140695|gb|AAD04167.1|  LocusLink info uroporphyrinogen decarboxylase [Homo sapiens]
          Length = 100

 Score =  104 bits (259), Expect = 2e-20
 Identities = 51/51 (100%), Positives = 51/51 (100%)
 Frame = +1

Query: 2758 MTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
            MTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct: 4    MTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 54

 Score = 95.1 bits (235), Expect = 1e-17
 Identities = 46/46 (100%), Positives = 46/46 (100%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM 3416
            ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM
Sbjct: 55   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM 100
>gi|3915203|sp|O18601|DCUP_DROVI   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|2317917|gb|AAB66372.1|   uroprophyrinogen decarboxylase [Drosophila virilis]
          Length = 386

 Score =  103 bits (256), Expect = 4e-20
 Identities = 65/161 (40%), Positives = 83/161 (51%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            QALG+ V M  G GP  P+P+   +DL+RL  P+   S L YV  AIT+ R +L GRVPL
Sbjct: 99   QALGLTVEMHAGVGPVLPQPICTPEDLKRLT-PDGALSRLTYVGDAITMMRHKLDGRVPL 157

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGF GAP               W + G                        YM+EGGGS 
Sbjct: 158  IGFTGAP---------------WTLMG------------------------YMIEGGGSK 178

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            TM++AK WL   P+ +   L +LTD +V YL  QV+AGAQ+
Sbjct: 179  TMSKAKAWLTNYPEDTKLFLILLTDVIVDYLEMQVIAGAQM 219

 Score = 56.2 bits (134), Expect(2) = 1e-12
 Identities = 26/36 (72%), Positives = 26/36 (72%)
 Frame = +3

Query: 1752 QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            Q FP LKND  LRAA GE  D  PVW MRQAGRYLP
Sbjct: 16   QAFPPLKNDNLLRAARGEVVDRVPVWVMRQAGRYLP 51

 Score = 48.9 bits (115), Expect(2) = 6e-07
 Identities = 40/132 (30%), Positives = 58/132 (43%)
 Frame = +3

Query: 3282 LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF 3461
            LQ+FES A HL  + F   + PY+R +   +  RL +  +  VP+V      +  +L   
Sbjct: 220  LQVFESSAEHLSKEEFLLGSEPYLRRIRDDLVDRLTKKVIPAVPLVSSYPNNIFTLL--- 276

Query: 3462 QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV 3641
                                        L SL      IIFAK    +L+E ++ GY+V+
Sbjct: 277  --------------------------TYLISLL-----IIFAKGAGHSLKEQSELGYDVI 305

Query: 3642 GLDWTVAPKKAR 3677
            GLDWTV P +AR
Sbjct: 306  GLDWTVDPVEAR 317

 Score = 42.0 bits (97), Expect(2) = 1e-12
 Identities = 28/76 (36%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQVRGPQKRERFMPSVCHLATCLLFPTA---TASL 2145
            EF+E R   DFF+ CR+PE  CE+T+Q   P +R     S+   +  L+ P A   T  +
Sbjct: 52   EFQELRKQHDFFTVCRTPELACEVTMQ---PLRRFDLDASII-FSDILVIPQALGLTVEM 107

Query: 2146 PSGCCHHFLRHPCCTP 2193
             +G     L  P CTP
Sbjct: 108  HAG-VGPVLPQPICTP 122

 Score = 41.6 bits (96), Expect = 0.13
 Identities = 19/23 (82%), Positives = 22/23 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQ 2194
            +QPLRRF LDA+IIFSDILV+PQ
Sbjct: 77   MQPLRRFDLDASIIFSDILVIPQ 99

 Score = 35.4 bits (80), Expect = 9.7
 Identities = 16/43 (37%), Positives = 23/43 (53%)
 Frame = +3

Query: 4182 EIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVH 4310
            E+  L  +M+   G  RYIAN+GHG+ P      +   V+A H
Sbjct: 341  ELRSLATEMVHKCGKSRYIANVGHGITPQTPITSMEVLVEAAH 383

 Score = 30.0 bits (66), Expect(2) = 6e-07
 Identities = 12/21 (57%), Positives = 16/21 (76%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALY 3837
            +R  VG  +TLQGNLDP ++Y
Sbjct: 316  ARAVVGPNITLQGNLDPQSMY 336
>gi|32418962|ref|XP_329959.1|   hypothetical protein [Neurospora crassa]
 gi|28926041|gb|EAA35030.1|   hypothetical protein [Neurospora crassa]
          Length = 390

 Score =  101 bits (252), Expect = 1e-19
 Identities = 63/164 (38%), Positives = 83/164 (50%), Gaps = 3/164 (1%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQD---LERLRDPEVVASELGYVFQAITLTRQRLAGR 2601
            QA+GM V MV  KGP FP PLR   D    E ++    VA EL YV++AITLTR++L GR
Sbjct: 109  QAMGMTVEMVDKKGPHFPNPLRSPSDGQYAELMKRDVDVAKELDYVYKAITLTRKKLDGR 168

Query: 2602 VPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGG 2781
            VPL GF GAP               W +                        + YMVEGG
Sbjct: 169  VPLFGFTGAP---------------WTL------------------------LCYMVEGG 189

Query: 2782 GSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            G+    + K W+Y+ P+ +  LL+ +++  V YL  QV AGAQ+
Sbjct: 190  GTKLFKEVKTWIYKYPEETKALLQKISELCVEYLALQVKAGAQI 233

 Score = 57.4 bits (137), Expect(2) = 3e-07
 Identities = 43/149 (28%), Positives = 56/149 (37%), Gaps = 2/149 (1%)
 Frame = +3

Query: 3234 SSLCVTYFSSPYPN*A--LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP 3407
            S LCV Y +      A  +Q+F+S AG L P  F  F+ PY+  +AK +  RL+E GL P
Sbjct: 216  SELCVEYLALQVKAGAQIVQVFDSWAGELSPSSFKTFSQPYLTYIAKHLPLRLKEMGLEP 275

Query: 3408 VPMVRIGMG*VKVVLWSFQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFA 3587
            VPMV                                                     +F 
Sbjct: 276  VPMV-----------------------------------------------------VFP 282

Query: 3588 KDGHFALEELAQAGYEVVGLDWTVAPKKA 3674
            K   +AL+     GY VVGLDW   P +A
Sbjct: 283  KGAWYALDAACDMGYNVVGLDWLHDPAEA 311

 Score = 37.4 bits (85), Expect(3) = 9e-07
 Identities = 19/30 (63%), Positives = 23/30 (76%), Gaps = 2/30 (6%)
 Frame = +2

Query: 2126 LQPLRRF--LLDAAIIFSDILVVPQVPTQT 2209
            LQP+ R+  L+DAAIIFSDILV+PQ    T
Sbjct: 85   LQPIERYAGLIDAAIIFSDILVIPQAMGMT 114

 Score = 35.8 bits (81), Expect = 7.4
 Identities = 20/63 (31%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDF---GPHR-YIANLGHGLYPDMDPEHVGAFVDA 4304
            L G      L    E I ++V++M+  F   G H+ +I NLGHG+ P ++P+ +  F + 
Sbjct: 322  LQGNADPGVLYGSHEAITKVVEEMVQGFDWHGRHKGWIVNLGHGITPFVNPDDLKFFFEE 381

Query: 4305 VHK 4313
            +H+
Sbjct: 382  IHR 384

 Score = 33.9 bits (76), Expect(3) = 9e-07
 Identities = 13/27 (48%), Positives = 17/27 (62%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            E+ E +  +DFF  CR+PE    LTLQ
Sbjct: 60   EYHEAKGGRDFFEVCRNPEIASTLTLQ 86

 Score = 26.2 bits (56), Expect(3) = 9e-07
 Identities = 16/34 (47%), Positives = 17/34 (50%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            FP LKND  LRAA            +  AGRYLP
Sbjct: 34   FPPLKNDLLLRAARAP--------LILTAGRYLP 59

 Score = 22.7 bits (47), Expect(2) = 3e-07
 Identities = 9/17 (52%), Positives = 11/17 (64%)
 Frame = +1

Query: 3793 KTVTLQGNLDPCALYAS 3843
            + + LQGN DP  LY S
Sbjct: 318  RPMVLQGNADPGVLYGS 334
>gi|38110215|gb|EAA55971.1|   hypothetical protein MG01622.4 [Magnaporthe grisea 70-15]
          Length = 367

 Score =  101 bits (251), Expect = 1e-19
 Identities = 63/164 (38%), Positives = 85/164 (51%), Gaps = 3/164 (1%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQD---LERLRDPEVVASELGYVFQAITLTRQRLAGR 2601
            QA+GM V MV  KGP FP PL+   D    E L     V+ EL YV++AITLTR++L GR
Sbjct: 88   QAMGMVVEMVDKKGPHFPNPLQSPDDGQYAEVLARDVDVSKELDYVYKAITLTRKKLQGR 147

Query: 2602 VPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGG 2781
            VPLIGF GAP               W ++                         YMVEGG
Sbjct: 148  VPLIGFCGAP---------------WTLF------------------------CYMVEGG 168

Query: 2782 GSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV 2913
            G+    Q+K+W+++ P+ S ++L+ + +  V YL  QV AGAQ+
Sbjct: 169  GTKLFIQSKKWIFRHPEESKKMLQKIAELCVEYLALQVQAGAQL 212

 Score = 60.1 bits (144), Expect(2) = 5e-08
 Identities = 42/149 (28%), Positives = 59/149 (39%), Gaps = 2/149 (1%)
 Frame = +3

Query: 3234 SSLCVTYFSSPYPN*A--LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAP 3407
            + LCV Y +      A  +Q+F+S AG L P  F +F+ PY+R +++ +  RL+E  L P
Sbjct: 195  AELCVEYLALQVQAGAQLVQVFDSWAGELSPASFEQFSAPYLRYISENLPKRLKELSLDP 254

Query: 3408 VPMVRIGMG*VKVVLWSFQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFA 3587
            VPM+                                                     +F 
Sbjct: 255  VPMI-----------------------------------------------------VFP 261

Query: 3588 KDGHFALEELAQAGYEVVGLDWTVAPKKA 3674
            K   FALE+    GY VVGLDW  +P KA
Sbjct: 262  KGAWFALEDCCAMGYNVVGLDWLYSPAKA 290

 Score = 51.2 bits (121), Expect(3) = 2e-13
 Identities = 20/34 (58%), Positives = 25/34 (73%)
 Frame = +3

Query: 1758 FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            F  LKND  +R AWG++ +  P+W MRQAGRYLP
Sbjct: 5    FEPLKNDLVIRTAWGQKVERPPIWIMRQAGRYLP 38

 Score = 37.0 bits (84), Expect(3) = 2e-13
 Identities = 19/25 (76%), Positives = 22/25 (88%), Gaps = 2/25 (8%)
 Frame = +2

Query: 2126 LQPLRRF--LLDAAIIFSDILVVPQ 2194
            LQP+ RF  LLDA+IIFSDILV+PQ
Sbjct: 64   LQPIDRFDGLLDASIIFSDILVIPQ 88

 Score = 32.7 bits (73), Expect(3) = 2e-13
 Identities = 13/27 (48%), Positives = 16/27 (59%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            E+ E +  +DFF  CR PE    LTLQ
Sbjct: 39   EYHEAKGNRDFFECCRDPEVASTLTLQ 65

 Score = 22.7 bits (47), Expect(2) = 5e-08
 Identities = 8/18 (44%), Positives = 12/18 (66%)
 Frame = +1

Query: 3793 KTVTLQGNLDPCALYASE 3846
            + + LQGN DP  LY ++
Sbjct: 297  REIVLQGNADPGVLYGTK 314
>gi|21674849|ref|NP_662914.1|   uroporphyrinogen decarboxylase [Chlorobium tepidum TLS]
 gi|29611777|sp|Q8KAW2|DCUP_CHLTE   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|21648071|gb|AAM73256.1|   uroporphyrinogen decarboxylase [Chlorobium tepidum TLS]
          Length = 351

 Score = 90.5 bits (223), Expect = 3e-16
 Identities = 55/159 (34%), Positives = 81/159 (50%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            +A+GM V ++  KG     P+R + D+++L DP++   +LGYV  AI L ++ L  RVPL
Sbjct: 80   EAMGMNVEIIETKGIKLTPPIRSQADIDKLIDPDI-DEKLGYVLDAIRLAKKELNDRVPL 138

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGF+GA                W ++                        TY VEGGGS 
Sbjct: 139  IGFSGA---------------AWTLF------------------------TYAVEGGGSK 159

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGA 2907
                AK+ +Y+ P+ +HQLL+ ++D +  YLV QV AGA
Sbjct: 160  NYTWAKKMMYREPKMAHQLLQKISDCISAYLVKQVEAGA 198

 Score = 45.8 bits (107), Expect(3) = 8e-10
 Identities = 20/31 (64%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND F+RA   + T  TP+W MRQAGRYLP
Sbjct: 2    LKNDLFIRALKRQATPRTPIWVMRQAGRYLP 32

 Score = 37.4 bits (85), Expect = 2.5
 Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 4/51 (7%)
 Frame = +3

Query: 4179 EEIGQLVKQMLDDFGPHR----YIANLGHGLYPDMDPEHVGAFVDAVHKHS 4319
            E+I     ++L  FG H     ++ NLGHG+ PD+DP ++   V+ V + S
Sbjct: 297  EKIKSEAAKVLKQFGQHNDHSGHVFNLGHGILPDVDPANLKCLVEFVKEES 347

 Score = 33.9 bits (76), Expect(3) = 8e-10
 Identities = 12/27 (44%), Positives = 18/27 (66%)
 Frame = +1

Query: 1975 EFRETRAAQDFFSTCRSPEACCELTLQ 2055
            E+R  R   DF + C++PE  CE+T+Q
Sbjct: 33   EYRAVREKTDFLTLCKTPELACEVTIQ 59

 Score = 32.3 bits (72), Expect(2) = 1.4
 Identities = 15/34 (44%), Positives = 20/34 (58%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I FAKD +  L ++A  G + VGL W +   KAR
Sbjct: 241  IAFAKDMNTILSDIADCGADAVGLGWNIDIAKAR 274

 Score = 28.5 bits (62), Expect(3) = 8e-10
 Identities = 14/21 (66%), Positives = 17/21 (80%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVV 2188
            +QP+    +DAAIIFSDILVV
Sbjct: 58   IQPVDLMGVDAAIIFSDILVV 78

 Score = 24.6 bits (52), Expect(2) = 1.4
 Identities = 10/23 (43%), Positives = 15/23 (65%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYAS 3843
            +R+ +   V LQGN+DP  LY +
Sbjct: 273  ARKELNDRVCLQGNMDPTVLYGT 295
>gi|21232275|ref|NP_638192.1|   uroporphyrinogen decarboxylase [Xanthomonas campestris pv. campestris
            str. ATCC 33913]
 gi|23813977|sp|Q8P6X1|DCUP_XANCP   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|21114039|gb|AAM42116.1|   uroporphyrinogen decarboxylase [Xanthomonas campestris pv. campestris
            str. ATCC 33913]
          Length = 354

 Score = 88.2 bits (217), Expect = 1e-15
 Identities = 56/159 (35%), Positives = 76/159 (47%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+E+  V G+GP F  P+R+   + RL  P++  +EL YV  A+ L R+ L G VPLI
Sbjct: 82   AMGLELYFVEGEGPKFRHPVRDADAIHRLGVPDM-ETELRYVMDAVRLIRRELDGAVPLI 140

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                      YM+EGGGS  
Sbjct: 141  GFSGSP--WTLA-------------------------------------CYMIEGGGSKE 161

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
             A+ K   +  PQ  H LL  +TDA++ YL  Q  AGAQ
Sbjct: 162  YARIKAMAFNAPQLLHHLLSTVTDAVIAYLSAQRAAGAQ 200

 Score = 45.4 bits (106), Expect(3) = 1e-10
 Identities = 21/31 (67%), Positives = 22/31 (70%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND  LRA   +  D TPVW MRQAGRYLP
Sbjct: 2    LKNDRLLRALRRQPVDRTPVWLMRQAGRYLP 32

 Score = 41.6 bits (96), Expect = 0.13
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
 Frame = +3

Query: 4176 QEEIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVHKHSR 4322
            + E+G+ +       G  R  ++ NLGHG+ PDM+P+HVG  V+AV   S+
Sbjct: 303  RSEVGKTLDSYAYGNGGSREGHVFNLGHGMSPDMNPDHVGVLVEAVQTLSK 353

 Score = 38.5 bits (88), Expect = 1.1
 Identities = 18/52 (34%), Positives = 33/52 (63%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG 3434
            ALQ+F++  G L P ++ +F+LPY+  +A++++   R +G    P+V  G G
Sbjct: 201  ALQVFDTWGGVLSPAMYREFSLPYLTRIAQELE---RGSGEERTPLVLFGKG 249

 Score = 37.7 bits (86), Expect(3) = 1e-10
 Identities = 17/22 (77%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL RF LDAAI+FSDIL +P
Sbjct: 59   LQPLERFPLDAAILFSDILTIP 80

 Score = 31.2 bits (69), Expect(2) = 0.19
 Identities = 12/29 (41%), Positives = 19/29 (65%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVA 3662
            ++F K     + ELA +G E VG+DWT++
Sbjct: 244  VLFGKGNGAYVSELAASGAEAVGVDWTIS 272

 Score = 28.9 bits (63), Expect(2) = 0.19
 Identities = 14/27 (51%), Positives = 15/27 (55%)
 Frame = +1

Query: 3781 ECVGKTVTLQGNLDPCALYASEVTARA 3861
            E  G  V LQGNLDP  LY S    R+
Sbjct: 278  ERAGGRVALQGNLDPATLYGSPDAIRS 304

 Score = 28.1 bits (61), Expect(3) = 1e-10
 Identities = 13/28 (46%), Positives = 18/28 (64%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A  F    ++P+  CE+TLQ
Sbjct: 33   EYRATRARAGSFLGMAKNPDIACEVTLQ 60
>gi|21243740|ref|NP_643322.1|   uroporphyrinogen decarboxylase [Xanthomonas axonopodis pv. citri str.
            306]
 gi|23813978|sp|Q8PI85|DCUP_XANAC   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|21109326|gb|AAM37858.1|   uroporphyrinogen decarboxylase [Xanthomonas axonopodis pv. citri str.
            306]
          Length = 354

 Score = 86.7 bits (213), Expect = 4e-15
 Identities = 54/159 (33%), Positives = 76/159 (47%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+E+  V G+GP F  P+R+   + RL  P++  +EL YV  A+ + R+ L G VPLI
Sbjct: 82   AMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDM-ETELRYVMDAVRVIRRELDGSVPLI 140

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                      YM+EGGGS  
Sbjct: 141  GFSGSP--WTLA-------------------------------------CYMIEGGGSKE 161

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
             A+ K   +  P+  H LL  +TDA++ YL  Q  AGAQ
Sbjct: 162  YARIKAMAFNAPELLHHLLNTVTDAVIAYLAAQRAAGAQ 200

 Score = 45.1 bits (105), Expect(3) = 1e-10
 Identities = 21/31 (67%), Positives = 22/31 (70%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND  LRA   +  D TPVW MRQAGRYLP
Sbjct: 2    LKNDRLLRALNRQPVDRTPVWLMRQAGRYLP 32

 Score = 43.5 bits (101), Expect = 0.035
 Identities = 21/49 (42%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
 Frame = +3

Query: 4182 EIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVHKHSR 4322
            E+G+ +       G  R  ++ NLGHG+ PDM+PEHVG  V+AV   S+
Sbjct: 305  EVGKTLDSYAQGNGGSREGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSK 353

 Score = 38.5 bits (88), Expect = 1.1
 Identities = 18/52 (34%), Positives = 32/52 (61%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG 3434
            ALQ+F++  G L P ++ +F+LPY+  +A++++   R  G    P+V  G G
Sbjct: 201  ALQVFDTWGGVLSPAMYREFSLPYLTRIARELE---RGDGAERTPLVLFGKG 249

 Score = 38.1 bits (87), Expect(3) = 1e-10
 Identities = 17/22 (77%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL+RF LDAAI+FSDIL +P
Sbjct: 59   LQPLQRFPLDAAILFSDILTIP 80

 Score = 28.1 bits (61), Expect(3) = 1e-10
 Identities = 13/28 (46%), Positives = 18/28 (64%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A  F    ++P+  CE+TLQ
Sbjct: 33   EYRATRARAGSFLGMAKNPDIACEVTLQ 60
>gi|28872231|ref|NP_794850.1|   uroporphyrinogen decarboxylase [Pseudomonas syringae pv. tomato str.
            DC3000]
 gi|38257459|sp|Q87V23|DCUP_PSESM   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|28855485|gb|AAO58545.1|   uroporphyrinogen decarboxylase [Pseudomonas syringae pv. tomato str.
            DC3000]
          Length = 354

 Score = 85.1 bits (209), Expect = 1e-14
 Identities = 56/159 (35%), Positives = 75/159 (47%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F + +    D+E L  P+    +LGYV  A++  R+ L GRVPLI
Sbjct: 84   AMGLGLYFETGEGPRFKKTVSTLADIEALPIPDA-QQDLGYVMDAVSTIRRELNGRVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GFAG+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFAGSP--WTLA-------------------------------------TYMVEGGSSKD 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              ++K  LY  PQA H LL  L  ++  YL GQ++AGAQ
Sbjct: 164  FRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQ 202

 Score = 48.5 bits (114), Expect(3) = 1e-12
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   +  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRFLRALLKQPVDVTPVWMMRQAGRYLP 34

 Score = 45.1 bits (105), Expect = 0.012
 Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    + L    E I Q V ++L  +G    ++ NLGHG+ P++DP + GAF++AVH+
Sbjct: 288  LQGNMDPTVLYARPEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHE 347

Query: 4314 HSRLLRQ 4334
             S    Q
Sbjct: 348  LSAQYHQ 354

 Score = 37.7 bits (86), Expect = 1.9
 Identities = 30/105 (28%), Positives = 42/105 (40%)
 Frame = +1

Query: 3694 EALRLRWGCWLGELPCMQLPERGAGFASRECVGKTVTLQGNLDPCALYASEVTARAPLCV 3873
            + L L W C +GE              +R+ VG  V+LQGN+DP  LYA     R  +  
Sbjct: 265  DTLGLDWTCDIGE--------------ARQRVGNKVSLQGNMDPTVLYARPEAIRQEVAR 310

Query: 3874 LLLCTPVACGCIILCALVFNVCLSFSSHLYTISPRKTGLFVAVVH 4008
            +L       G       VFN+    +     + P   G F+  VH
Sbjct: 311  ILASYGSGTG------HVFNLGHGITPE---VDPANAGAFINAVH 346

 Score = 35.8 bits (81), Expect(3) = 1e-12
 Identities = 16/22 (72%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL R+ LDAAI+FSDIL +P
Sbjct: 61   LQPLDRYPLDAAILFSDILTIP 82

 Score = 33.5 bits (75), Expect(3) = 1e-12
 Identities = 15/28 (53%), Positives = 21/28 (75%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R +RA A DF S C++P+  CE+TLQ
Sbjct: 35   EYRASRASAGDFMSLCKNPQFACEVTLQ 62
>gi|16123871|ref|NP_407184.1|   uroporphyrinogen decarboxylase [Yersinia pestis]
 gi|22124411|ref|NP_667834.1|   uroporphyrinogen decarboxylase [Yersinia pestis KIM]
 gi|23813999|sp|Q8ZAQ7|DCUP_YERPE   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|25291020|pir||AF0454   uroporphyrinogen decarboxylase (EC 4.1.1.37) [imported] - Yersinia
            pestis (strain CO92)
 gi|15981650|emb|CAC93202.1|   uroporphyrinogen decarboxylase [Yersinia pestis CO92]
 gi|21957194|gb|AAM84085.1|   uroporphyrinogen decarboxylase [Yersinia pestis KIM]
          Length = 355

 Score = 84.7 bits (208), Expect = 1e-14
 Identities = 55/159 (34%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+    D+E+L  P+    ELGYV  A+   R+ LAG VPLI
Sbjct: 84   AMGLGLYFETGEGPRFQSPITCRADVEKLPIPDP-EQELGYVMNAVRTIRRELAGSVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              + K+ +Y  PQ  H LL  L D+++ YL  Q+ AGAQ
Sbjct: 164  FTKLKKMMYAEPQTLHLLLDKLADSVILYLNAQIKAGAQ 202

 Score = 50.4 bits (119), Expect = 3e-04
 Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L  P   I Q V  +L  FG    ++ NLGHG++ D+ P H GAFV+AVH 
Sbjct: 288  LQGNMDPSVLYAPPARIEQEVSTILASFGQGEGHVFNLGHGIHQDVPPAHAGAFVNAVHA 347

Query: 4314 HSRLLRQ 4334
             SR   Q
Sbjct: 348  LSRPYHQ 354

 Score = 49.3 bits (116), Expect(3) = 8e-13
 Identities = 22/32 (68%), Positives = 24/32 (75%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  D TPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLRQPVDMTPVWMMRQAGRYLP 34

 Score = 37.7 bits (86), Expect(3) = 8e-13
 Identities = 16/22 (72%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            +QPLRR+ LDAAI+FSDIL +P
Sbjct: 61   MQPLRRYPLDAAILFSDILTIP 82

 Score = 31.6 bits (70), Expect(3) = 8e-13
 Identities = 14/28 (50%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF S C++ E  CE+T+Q
Sbjct: 35   EYKATRAIAGDFMSLCKNAELACEVTMQ 62

 Score = 31.2 bits (69), Expect(2) = 0.19
 Identities = 26/78 (33%), Positives = 31/78 (39%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSS 3954
            +R  VG  V LQGN+DP  LYA        +  +L       G       VFN  L    
Sbjct: 278  ARRRVGDKVALQGNMDPSVLYAPPARIEQEVSTILASFGQGEG------HVFN--LGHGI 329

Query: 3955 HLYTISPRKTGLFVAVVH 4008
            H   + P   G FV  VH
Sbjct: 330  H-QDVPPAHAGAFVNAVH 346

 Score = 28.9 bits (63), Expect(2) = 0.19
 Identities = 14/33 (42%), Positives = 18/33 (54%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            +F K G   LE +A  G + +GLDWT     AR
Sbjct: 247  LFTKGGGPWLEAMAATGCDALGLDWTTDIADAR 279
>gi|33598623|ref|NP_886266.1|   uroporphyrinogen decarboxylase [Bordetella parapertussis]
 gi|33574752|emb|CAE39411.1|   uroporphyrinogen decarboxylase [Bordetella parapertussis]
          Length = 358

 Score = 84.3 bits (207), Expect = 2e-14
 Identities = 55/159 (34%), Positives = 73/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +   PG+GP F  P+R+E D+ +L  P++    L YVF A+   R+ L GRVPLI
Sbjct: 86   AMGLGLDFAPGEGPRFAHPVRDESDVAKLAVPDM--DSLRYVFDAVRTIRRELDGRVPLI 143

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GFAG+P               W +                          YMVEG GS  
Sbjct: 144  GFAGSP---------------WTI------------------------ACYMVEGRGSDD 164

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K  LY RP   H++L I  +A   YL  Q+ AGAQ
Sbjct: 165  YRLIKSMLYGRPDLLHRILEINAEATRHYLNAQIDAGAQ 203

 Score = 50.1 bits (118), Expect(3) = 6e-11
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   E   YTP+W MRQAGRYLP
Sbjct: 6    LKNDVFLRALLREPVPYTPIWLMRQAGRYLP 36

 Score = 37.0 bits (84), Expect = 3.3
 Identities = 20/46 (43%), Positives = 26/46 (56%), Gaps = 3/46 (6%)
 Frame = +3

Query: 4200 KQMLDDFGP---HRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLL 4328
            ++ LD FGP     ++ NLGHG+     PE V   VD VH +SR L
Sbjct: 310  RRTLDAFGPVGKGGHVFNLGHGISQYSPPEVVSELVDEVHTYSRAL 355

 Score = 36.6 bits (83), Expect(3) = 6e-11
 Identities = 17/22 (77%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL R+ LDAAI+FSDIL VP
Sbjct: 63   LQPLARYPLDAAILFSDILTVP 84

 Score = 36.2 bits (82), Expect = 5.7
 Identities = 18/34 (52%), Positives = 22/34 (64%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I+F+K G   LEE+A  G + VGLDWTV    AR
Sbjct: 247  IVFSKGGGQWLEEIAACGCDAVGLDWTVNLGTAR 280

 Score = 25.4 bits (54), Expect(3) = 6e-11
 Identities = 12/28 (42%), Positives = 17/28 (60%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+  TRA A  F    ++P+  CE+TLQ
Sbjct: 37   EYNATRARAGSFMGLAQNPDYACEVTLQ 64
>gi|33603574|ref|NP_891134.1|   uroporphyrinogen decarboxylase [Bordetella bronchiseptica]
 gi|33577699|emb|CAE34964.1|   uroporphyrinogen decarboxylase [Bordetella bronchiseptica]
          Length = 358

 Score = 84.3 bits (207), Expect = 2e-14
 Identities = 55/159 (34%), Positives = 73/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +   PG+GP F  P+R+E D+ +L  P++    L YVF A+   R+ L GRVPLI
Sbjct: 86   AMGLGLDFAPGEGPRFAHPVRDESDVAKLAVPDM--DSLRYVFDAVRTIRRELDGRVPLI 143

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GFAG+P               W +                          YMVEG GS  
Sbjct: 144  GFAGSP---------------WTI------------------------ACYMVEGRGSDD 164

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K  LY RP   H++L I  +A   YL  Q+ AGAQ
Sbjct: 165  YRLIKSMLYGRPDLLHRILEINAEATRHYLNAQIDAGAQ 203

 Score = 50.1 bits (118), Expect(3) = 6e-11
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   E   YTP+W MRQAGRYLP
Sbjct: 6    LKNDVFLRALLREPVPYTPIWLMRQAGRYLP 36

 Score = 37.0 bits (84), Expect = 3.3
 Identities = 20/46 (43%), Positives = 26/46 (56%), Gaps = 3/46 (6%)
 Frame = +3

Query: 4200 KQMLDDFGP---HRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLL 4328
            ++ LD FGP     ++ NLGHG+     PE V   VD VH +SR L
Sbjct: 310  RRTLDAFGPVGKGGHVFNLGHGISQYSPPEVVSELVDEVHTYSRAL 355

 Score = 36.6 bits (83), Expect(3) = 6e-11
 Identities = 17/22 (77%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL R+ LDAAI+FSDIL VP
Sbjct: 63   LQPLARYPLDAAILFSDILTVP 84

 Score = 35.8 bits (81), Expect = 7.4
 Identities = 18/34 (52%), Positives = 21/34 (61%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I+F K G   LEE+A  G + VGLDWTV    AR
Sbjct: 247  IVFTKGGGQWLEEIAACGCDAVGLDWTVNLGTAR 280

 Score = 25.4 bits (54), Expect(3) = 6e-11
 Identities = 12/28 (42%), Positives = 17/28 (60%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+  TRA A  F    ++P+  CE+TLQ
Sbjct: 37   EYNATRARAGSFMGLAQNPDYACEVTLQ 64
>gi|23469744|ref|ZP_00125078.1|   COG0407: Uroporphyrinogen-III decarboxylase [Pseudomonas syringae pv.
            syringae B728a]
          Length = 354

 Score = 84.0 bits (206), Expect = 2e-14
 Identities = 56/159 (35%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G  +    G+GP F + +    D+E L  P+    +LGYV  A++  R+ L GRVPLI
Sbjct: 84   AMGQGLYFETGEGPRFRKTVSTLADIEALPIPDA-QQDLGYVMDAVSTIRRELNGRVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GFAG+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFAGSP--WTLA-------------------------------------TYMVEGGSSKD 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              ++K  LY  PQA H LL  L  ++  YL GQ++AGAQ
Sbjct: 164  FRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQ 202

 Score = 48.5 bits (114), Expect(3) = 1e-12
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   +  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRFLRALLKQPVDVTPVWMMRQAGRYLP 34

 Score = 44.7 bits (104), Expect = 0.016
 Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 1/62 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    + L    E I Q V ++L  +G    ++ NLGHG+ P++DP + GAF++AVH+
Sbjct: 288  LQGNMDPTVLYARPEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHE 347

Query: 4314 HS 4319
             S
Sbjct: 348  LS 349

 Score = 37.7 bits (86), Expect = 1.9
 Identities = 30/105 (28%), Positives = 42/105 (40%)
 Frame = +1

Query: 3694 EALRLRWGCWLGELPCMQLPERGAGFASRECVGKTVTLQGNLDPCALYASEVTARAPLCV 3873
            + L L W C +GE              +R+ VG  V+LQGN+DP  LYA     R  +  
Sbjct: 265  DTLGLDWTCDIGE--------------ARQRVGSKVSLQGNMDPTVLYARPEAIRQEVAR 310

Query: 3874 LLLCTPVACGCIILCALVFNVCLSFSSHLYTISPRKTGLFVAVVH 4008
            +L       G       VFN+    +     + P   G F+  VH
Sbjct: 311  ILASYGSGTG------HVFNLGHGITPE---VDPANAGAFINAVH 346

 Score = 36.2 bits (82), Expect(3) = 1e-12
 Identities = 17/27 (62%), Positives = 20/27 (74%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVPQVPTQ 2206
            LQPL R+ LDAAI+FSDIL +P    Q
Sbjct: 61   LQPLDRYPLDAAILFSDILTIPDAMGQ 87

 Score = 33.5 bits (75), Expect(3) = 1e-12
 Identities = 15/28 (53%), Positives = 21/28 (75%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R +RA A DF S C++P+  CE+TLQ
Sbjct: 35   EYRASRASAGDFMSLCKNPQFACEVTLQ 62
>gi|33594189|ref|NP_881833.1|   uroporphyrinogen decarboxylase [Bordetella pertussis]
 gi|33564264|emb|CAE43556.1|   uroporphyrinogen decarboxylase [Bordetella pertussis]
          Length = 358

 Score = 82.8 bits (203), Expect = 5e-14
 Identities = 54/159 (33%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +   PG+GP F  P+R+E D+ +L  P++    L YVF A+   R+ L GRVPLI
Sbjct: 86   AMGLGLDFAPGEGPRFAHPVRDESDVAKLAVPDM--DSLRYVFDAVRTIRRELDGRVPLI 143

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GFAG+P               W +                          YM EG GS  
Sbjct: 144  GFAGSP---------------WTI------------------------ACYMAEGRGSDD 164

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K  LY RP   H++L I  +A   YL  Q+ AGAQ
Sbjct: 165  YRLIKSMLYGRPDLLHRILEINAEATRHYLNAQIDAGAQ 203

 Score = 50.1 bits (118), Expect(3) = 6e-11
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   E   YTP+W MRQAGRYLP
Sbjct: 6    LKNDVFLRALLREPVPYTPIWLMRQAGRYLP 36

 Score = 37.0 bits (84), Expect = 3.3
 Identities = 20/46 (43%), Positives = 26/46 (56%), Gaps = 3/46 (6%)
 Frame = +3

Query: 4200 KQMLDDFGP---HRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLL 4328
            ++ LD FGP     ++ NLGHG+     PE V   VD VH +SR L
Sbjct: 310  RRTLDAFGPVGKGGHVFNLGHGISQYSPPEVVSELVDEVHTYSRAL 355

 Score = 36.6 bits (83), Expect(3) = 6e-11
 Identities = 17/22 (77%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL R+ LDAAI+FSDIL VP
Sbjct: 63   LQPLARYPLDAAILFSDILTVP 84

 Score = 35.8 bits (81), Expect = 7.4
 Identities = 18/34 (52%), Positives = 21/34 (61%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I+F K G   LEE+A  G + VGLDWTV    AR
Sbjct: 247  IVFTKGGGQWLEEIAACGCDAVGLDWTVNLGAAR 280

 Score = 25.4 bits (54), Expect(3) = 6e-11
 Identities = 12/28 (42%), Positives = 17/28 (60%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+  TRA A  F    ++P+  CE+TLQ
Sbjct: 37   EYNATRARAGSFMGLAQNPDYACEVTLQ 64
>gi|23104868|ref|ZP_00091328.1|   COG0407: Uroporphyrinogen-III decarboxylase [Azotobacter vinelandii]
          Length = 355

 Score = 82.8 bits (203), Expect = 5e-14
 Identities = 56/159 (35%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F + +    D+E L  P+    +LGYV  A+   R+ L GRVPLI
Sbjct: 85   AMGLGLYFETGEGPRFRKVVSSPADIEALPVPDP-ERDLGYVMAAVRTIRRELNGRVPLI 143

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 144  GFSGSP--WTLA-------------------------------------TYMVEGGSSKD 164

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              ++K  LY  PQA H LL  L  A+  YL GQ++AGAQ
Sbjct: 165  FRKSKAMLYDNPQAMHALLDKLARAVTAYLNGQILAGAQ 203

 Score = 48.5 bits (114), Expect(3) = 5e-12
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   +  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRFLRALLKQPVDVTPVWMMRQAGRYLP 34

 Score = 42.4 bits (98), Expect = 0.079
 Identities = 16/29 (55%), Positives = 23/29 (79%)
 Frame = +3

Query: 4233 YIANLGHGLYPDMDPEHVGAFVDAVHKHS 4319
            ++ NLGHG+ P++DP H GAF +AVH+ S
Sbjct: 322  HVFNLGHGITPEVDPAHAGAFFEAVHELS 350

 Score = 39.7 bits (91), Expect = 0.51
 Identities = 35/119 (29%), Positives = 46/119 (38%)
 Frame = +1

Query: 3652 GQWPQRKPGKPWKGEALRLRWGCWLGELPCMQLPERGAGFASRECVGKTVTLQGNLDPCA 3831
            G W +   G     EAL L W C +G+              +R  VG  V LQGN+DP  
Sbjct: 254  GLWLEAMAGSG--AEALGLDWTCDIGD--------------ARARVGGKVALQGNMDPSV 297

Query: 3832 LYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSSHLYTISPRKTGLFVAVVH 4008
            LYA+    RA +  +L       G       VFN+    +     + P   G F   VH
Sbjct: 298  LYANPAAIRAEVARILARYGAGSG------HVFNLGHGITPE---VDPAHAGAFFEAVH 347

 Score = 35.4 bits (80), Expect(3) = 5e-12
 Identities = 17/28 (60%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A DF S C +PE  CE+TLQ
Sbjct: 35   EYRATRAKAGDFMSLCMNPELACEVTLQ 62

 Score = 32.0 bits (71), Expect(3) = 5e-12
 Identities = 17/23 (73%), Positives = 19/23 (82%), Gaps = 1/23 (4%)
 Frame = +2

Query: 2126 LQPLRRF-LLDAAIIFSDILVVP 2191
            LQPL R+  LDAAI+FSDIL VP
Sbjct: 61   LQPLDRYPQLDAAILFSDILTVP 83
>gi|22994377|ref|ZP_00038883.1|   COG0407: Uroporphyrinogen-III decarboxylase [Xylella fastidiosa
            Dixon]
          Length = 354

 Score = 82.8 bits (203), Expect = 5e-14
 Identities = 52/159 (32%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+E+  + G+GP   +P+R+   + +L  P++  +EL YV  A+ L R+ L   VPLI
Sbjct: 82   AMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDM-ETELRYVMDAVRLIRKELDNSVPLI 140

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                      YM+EGGGS  
Sbjct: 141  GFSGSP--WTLA-------------------------------------CYMIEGGGSKE 161

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
             A  K   +  P   HQLL  +TDA++ YL  Q  AGAQ
Sbjct: 162  YAHIKAMAFNAPDVLHQLLNTVTDAVISYLAAQRAAGAQ 200

 Score = 45.1 bits (105), Expect = 0.012
 Identities = 20/31 (64%), Positives = 22/31 (70%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND  LRA   +  D TP+W MRQAGRYLP
Sbjct: 2    LKNDRLLRALRRDTVDRTPIWLMRQAGRYLP 32

 Score = 42.0 bits (97), Expect = 0.10
 Identities = 17/30 (56%), Positives = 23/30 (76%)
 Frame = +3

Query: 4233 YIANLGHGLYPDMDPEHVGAFVDAVHKHSR 4322
            ++ NLGHG+ P MDP+HV A V+AV + SR
Sbjct: 324  HVFNLGHGMTPGMDPDHVSALVEAVQRLSR 353

 Score = 40.0 bits (92), Expect(2) = 0.002
 Identities = 18/22 (81%), Positives = 21/22 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRRF LDAAI+FSDIL++P
Sbjct: 59   LQPLRRFPLDAAILFSDILMIP 80

 Score = 38.5 bits (88), Expect = 1.1
 Identities = 18/52 (34%), Positives = 31/52 (59%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG 3434
            ALQ+F++  G L P ++  F+LPY+  +A++++   R  G    P+V  G G
Sbjct: 201  ALQVFDTWGGILSPTMYRTFSLPYLTRIARELE---RGTGTEHTPLVLFGKG 249

 Score = 26.6 bits (57), Expect(2) = 0.002
 Identities = 14/45 (31%), Positives = 20/45 (44%)
 Frame = +1

Query: 1921 RGGLWRASRLSPVFPLYAEFRETRAAQDFFSTCRSPEACCELTLQ 2055
            R  +W   +     P Y   R+   A  F    ++PE  CE+TLQ
Sbjct: 18   RTPIWLMRQAGRYLPEYRAARQH--AGSFLKMAKTPELACEITLQ 60
>gi|23138367|ref|ZP_00120028.1|   COG0407: Uroporphyrinogen-III decarboxylase [Cytophaga hutchinsonii]
          Length = 344

 Score = 82.4 bits (202), Expect = 7e-14
 Identities = 54/159 (33%), Positives = 74/159 (46%)
 Frame = +1

Query: 2431 QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL 2610
            +A+G+   M   KGP FP+ +    D++ L   +  A  L YV+ AI L  + L GRVPL
Sbjct: 82   EAMGLPYEMQESKGPFFPKVITSAADIDALLATDA-ADHLTYVYDAIELAVKELNGRVPL 140

Query: 2611 IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSS 2790
            IGFAGAP                                          + YM+EG GS 
Sbjct: 141  IGFAGAP---------------------------------------FTILAYMIEGQGSK 161

Query: 2791 TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGA 2907
            T ++A+R+LY  P  +H+LL  +T A + YL  QV AGA
Sbjct: 162  TFSKARRFLYTEPVLAHRLLEKITLATIAYLKRQVQAGA 200

 Score = 57.0 bits (136), Expect = 3e-06
 Identities = 28/49 (57%), Positives = 33/49 (67%)
 Frame = +3

Query: 4161 ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAV 4307
            AL + +E+I    K+MLD FG   +IANLGHGLYPD D   V  FVDAV
Sbjct: 289  ALYLSEEQIRVKAKEMLDAFGTQSHIANLGHGLYPDTDKTKVKCFVDAV 337

 Score = 44.3 bits (103), Expect = 0.021
 Identities = 20/32 (62%), Positives = 23/32 (71%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            + +ND  LRAA GE  + TPVW MRQAGR LP
Sbjct: 2    QYQNDLILRAARGEAVERTPVWLMRQAGRILP 33

 Score = 37.0 bits (84), Expect(2) = 0.053
 Identities = 16/28 (57%), Positives = 20/28 (71%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTAR 3858
            S++ +G   TLQGN+DPCALY SE   R
Sbjct: 271  SKKIIGPHKTLQGNMDPCALYLSEEQIR 298

 Score = 25.0 bits (53), Expect(2) = 0.053
 Identities = 10/27 (37%), Positives = 14/27 (51%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTV 3659
            +F+K   F  E+      E VGLDW +
Sbjct: 240  VFSKGAFFVREDFNNFPCETVGLDWNM 266
>gi|15603599|ref|NP_246673.1|   UroD [Pasteurella multocida]
 gi|13431433|sp|P57964|DCUP_PASMU   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|12722148|gb|AAK03818.1|   UroD [Pasteurella multocida]
          Length = 354

 Score = 82.4 bits (202), Expect = 7e-14
 Identities = 54/159 (33%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ ++   G+GP F  P+  ++ ++ L  P+    EL YV  A+   R+ L G VPLI
Sbjct: 84   AMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDP-EGELQYVMNAVRTIRRELKGEVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              + K+ LY  PQ  HQLL  L DA++ YL  Q+ AGAQ
Sbjct: 164  FTKIKKMLYADPQLLHQLLDKLADAVILYLNAQIKAGAQ 202

 Score = 47.4 bits (111), Expect(3) = 2e-13
 Identities = 21/31 (67%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND +L+A   E  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRYLKALLREPVDMTPVWMMRQAGRYLP 34

 Score = 39.7 bits (91), Expect = 0.51
 Identities = 22/63 (34%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L      I Q V+ +L DFG    ++ NLGHG++ D+  +    FV+A+H+
Sbjct: 288  LQGNMDPSVLYASPARIEQEVRSILADFGEGSGHVFNLGHGIHQDVPEQSPAVFVNAIHQ 347

Query: 4314 HSR 4322
             S+
Sbjct: 348  FSQ 350

 Score = 38.5 bits (88), Expect(3) = 2e-13
 Identities = 17/22 (77%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRR+ LDAAI+FSDIL +P
Sbjct: 61   LQPLRRYPLDAAILFSDILTIP 82

 Score = 34.7 bits (78), Expect(3) = 2e-13
 Identities = 17/28 (60%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A DF S CR+ E  CE+TLQ
Sbjct: 35   EYRATRAVAGDFMSLCRNAELACEVTLQ 62

 Score = 32.3 bits (72), Expect(2) = 0.041
 Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 2/35 (5%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTV--APKKAR 3677
            +F K G   LE +A+ G + +G+DWTV  A  KAR
Sbjct: 247  LFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKAR 281

 Score = 30.0 bits (66), Expect(2) = 0.041
 Identities = 13/19 (68%), Positives = 14/19 (73%)
 Frame = +1

Query: 3787 VGKTVTLQGNLDPCALYAS 3843
            VG  V LQGN+DP  LYAS
Sbjct: 282  VGHKVALQGNMDPSVLYAS 300
>gi|28899690|ref|NP_799295.1|   uroporphyrinogen decarboxylase [Vibrio parahaemolyticus RIMD 2210633]
 gi|31340033|sp|Q87KR0|DCUP_VIBPA   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|28807942|dbj|BAC61179.1|   uroporphyrinogen decarboxylase [Vibrio parahaemolyticus]
          Length = 355

 Score = 79.7 bits (195), Expect = 4e-13
 Identities = 55/161 (34%), Positives = 74/161 (45%), Gaps = 2/161 (1%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLER--LRDPEVVASELGYVFQAITLTRQRLAGRVP 2607
            A+G+ +    G+GP F  P+  + D+E+  L DPE    EL YV  A+   R+ L G VP
Sbjct: 84   AMGLGLRFAAGEGPVFDNPITCKADVEKIGLPDPE---GELQYVMNAVRQIRKDLNGDVP 140

Query: 2608 LIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGS 2787
            LIGF+G+P  W  A                                     TYMVEGG S
Sbjct: 141  LIGFSGSP--WTLA-------------------------------------TYMVEGGSS 161

Query: 2788 STMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                + K+ +Y  PQ  H LL  L D+++ YL  Q+ AGAQ
Sbjct: 162  KAFTKIKKMMYAEPQTLHLLLDKLADSVIDYLNAQIKAGAQ 202

 Score = 53.5 bits (127), Expect(3) = 1e-13
 Identities = 24/32 (75%), Positives = 25/32 (78%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   E  DYTPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLKEPVDYTPVWMMRQAGRYLP 34

 Score = 44.3 bits (103), Expect = 0.021
 Identities = 25/64 (39%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVH 4310
            L G    S L    E I + V  +L+ FG     ++ NLGHG++ D+ PE+ G FV+AVH
Sbjct: 288  LQGNMDPSMLYASPERIREEVAGILEGFGDAGTGHVFNLGHGIHLDVPPENAGVFVEAVH 347

Query: 4311 KHSR 4322
            + S+
Sbjct: 348  ELSK 351

 Score = 39.7 bits (91), Expect(3) = 1e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRRF LDAAI+FSDIL +P
Sbjct: 61   LQPLRRFPLDAAILFSDILTIP 82

 Score = 35.0 bits (79), Expect(2) = 9e-04
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 2/35 (5%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWT--VAPKKAR 3677
            +F K+G   LE++A  G + VGLDWT  +A  KAR
Sbjct: 247  LFTKNGGMWLEQIAATGCDAVGLDWTINIADAKAR 281

 Score = 33.1 bits (74), Expect(2) = 9e-04
 Identities = 27/74 (36%), Positives = 33/74 (44%)
 Frame = +1

Query: 3787 VGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSSHLYT 3966
            +G  V LQGN+DP  LYAS    R  +  +L     A         VFN  L    HL  
Sbjct: 282  IGDKVALQGNMDPSMLYASPERIREEVAGILEGFGDAG-----TGHVFN--LGHGIHL-D 333

Query: 3967 ISPRKTGLFVAVVH 4008
            + P   G+FV  VH
Sbjct: 334  VPPENAGVFVEAVH 347

 Score = 28.5 bits (62), Expect(3) = 1e-13
 Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF S C++ E   E+TLQ
Sbjct: 35   EYKATRAQAGDFMSLCKNAELASEVTLQ 62
>gi|26991750|ref|NP_747175.1|   uroporphyrinogen decarboxylase [Pseudomonas putida KT2440]
 gi|38257478|sp|Q88CV6|DCUP_PSEPK   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|24986857|gb|AAN70639.1|   uroporphyrinogen decarboxylase [Pseudomonas putida KT2440]
          Length = 354

 Score = 81.3 bits (199), Expect = 2e-13
 Identities = 54/159 (33%), Positives = 73/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F + +    D+E L  P+    +LGYV  A++  R+ L GRVPLI
Sbjct: 84   AMGLGLYFETGEGPRFKKVISTPADIEALPVPDP-QKDLGYVMDAVSTIRRELNGRVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKD 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              + K   Y  PQA H LL  L  ++  YL GQ++AGAQ
Sbjct: 164  FRKTKAMAYDNPQALHLLLDKLAQSVTSYLNGQILAGAQ 202

 Score = 48.5 bits (114), Expect = 0.001
 Identities = 26/67 (38%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    + L    E I + V ++L  +G    ++ NLGHG+ P++DPEH GAF++AVH+
Sbjct: 288  LQGNMDPTVLYAKPEAIRKEVARILASYGHGTGHVFNLGHGITPEVDPEHAGAFINAVHE 347

Query: 4314 HSRLLRQ 4334
             S    Q
Sbjct: 348  LSAQYHQ 354

 Score = 48.5 bits (114), Expect(3) = 3e-12
 Identities = 22/31 (70%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND FLRA   +  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRFLRALLKQPVDVTPVWMMRQAGRYLP 34

 Score = 37.0 bits (84), Expect = 3.3
 Identities = 30/105 (28%), Positives = 41/105 (39%)
 Frame = +1

Query: 3694 EALRLRWGCWLGELPCMQLPERGAGFASRECVGKTVTLQGNLDPCALYASEVTARAPLCV 3873
            +AL L W C +G+              +R  VG  V LQGN+DP  LYA     R  +  
Sbjct: 265  DALGLDWTCEIGD--------------ARRRVGDKVALQGNMDPTVLYAKPEAIRKEVAR 310

Query: 3874 LLLCTPVACGCIILCALVFNVCLSFSSHLYTISPRKTGLFVAVVH 4008
            +L       G       VFN+    +     + P   G F+  VH
Sbjct: 311  ILASYGHGTG------HVFNLGHGITPE---VDPEHAGAFINAVH 346

 Score = 35.8 bits (81), Expect(3) = 3e-12
 Identities = 16/22 (72%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL R+ LDAAI+FSDIL +P
Sbjct: 61   LQPLDRYPLDAAILFSDILTIP 82

 Score = 35.4 bits (80), Expect = 9.7
 Identities = 16/34 (47%), Positives = 22/34 (64%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I+F K+G   LE +A+AG + +GLDWT     AR
Sbjct: 246  ILFTKNGGLWLESIAEAGADALGLDWTCEIGDAR 279

 Score = 32.3 bits (72), Expect(3) = 3e-12
 Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R +RA A DF S C +P+  CE+TLQ
Sbjct: 35   EYRASRAKAGDFMSLCMNPQFACEVTLQ 62
>gi|409791|gb|AAC43095.1|   uroporphyrinogen decarboxylase
          Length = 354

 Score = 78.2 bits (191), Expect = 1e-12
 Identities = 53/159 (33%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+  + D+++L  P+    ELGYV  A+   R+ L G VPLI
Sbjct: 84   AMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDP-EDELGYVMNAVRTIRRELKGEVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K+ +Y  PQA H LL  L  ++  YL  Q+ AGAQ
Sbjct: 164  FTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQ 202

 Score = 49.7 bits (117), Expect(3) = 2e-13
 Identities = 22/32 (68%), Positives = 24/32 (75%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  D TPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLXQPVDVTPVWMMRQAGRYLP 34

 Score = 47.8 bits (112), Expect = 0.002
 Identities = 26/62 (41%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L  P   I + V  +L  FG    ++ NLGHG++ D+ PEH G FV+AVH+
Sbjct: 288  LQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHR 347

Query: 4314 HS 4319
             S
Sbjct: 348  LS 349

 Score = 38.9 bits (89), Expect(3) = 2e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRR+ LDAAI+FSDIL VP
Sbjct: 61   LQPLRRYPLDAAILFSDILTVP 82

 Score = 32.3 bits (72), Expect(3) = 2e-13
 Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF S C++ E  CE+TLQ
Sbjct: 35   EYKATRAQAGDFMSLCKNAELACEVTLQ 62

 Score = 32.0 bits (71), Expect(2) = 0.041
 Identities = 26/78 (33%), Positives = 32/78 (41%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSS 3954
            +R  VG  V LQGN+DP  LYA        +  +L       G       VFN  L    
Sbjct: 278  ARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEG------HVFN--LGHGI 329

Query: 3955 HLYTISPRKTGLFVAVVH 4008
            H   + P   G+FV  VH
Sbjct: 330  H-QDVPPEHAGVFVEAVH 346

 Score = 30.4 bits (67), Expect(2) = 0.041
 Identities = 14/33 (42%), Positives = 19/33 (57%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            +F K G   LE +A+ G + +GLDWT     AR
Sbjct: 247  LFTKGGGQWLEAMAETGCDALGLDWTTDIADAR 279
>gi|34496577|ref|NP_900792.1|   uroporphyrinogen decarboxylase [Chromobacterium violaceum ATCC 12472]
 gi|34102431|gb|AAQ58797.1|   uroporphyrinogen decarboxylase [Chromobacterium violaceum ATCC 12472]
          Length = 331

 Score = 80.9 bits (198), Expect = 2e-13
 Identities = 51/159 (32%), Positives = 70/159 (44%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  PLR+E  +  L   ++   +L YVF A+   R+ L GRVPLI
Sbjct: 60   AMGLGLYFAEGEGPKFQRPLRDEAAIRALAPADM--GKLQYVFDAVASIRKALDGRVPLI 117

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P                                            YMVEGGGS  
Sbjct: 118  GFSGSP---------------------------------------FTLACYMVEGGGSDD 138

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K  LY RP+  H +L   T +++ YL  Q+ AGAQ
Sbjct: 139  FRHVKAMLYSRPELLHHILEANTQSVIAYLNAQIDAGAQ 177

 Score = 42.0 bits (97), Expect = 0.10
 Identities = 22/56 (39%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
 Frame = +3

Query: 4158 SALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHKHSR 4322
            +AL      I + V+++L  +G    ++ NLGHG+    DP H GA V+AVH+ SR
Sbjct: 270  NALFAEPAAIEREVERILQSYGQGSGHVFNLGHGISQFADPAHAGALVEAVHRLSR 325

 Score = 37.4 bits (85), Expect(3) = 5e-04
 Identities = 18/22 (81%), Positives = 19/22 (86%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPL RF LDAAI+FSDIL VP
Sbjct: 37   LQPLDRFPLDAAILFSDILTVP 58

 Score = 33.1 bits (74), Expect(2) = 0.11
 Identities = 16/34 (47%), Positives = 21/34 (61%)
 Frame = +3

Query: 3576 IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            I+F K G   LE++A  G + VGLDWT    +AR
Sbjct: 221  IVFTKGGGQWLEDIAAIGADCVGLDWTTDIGQAR 254

 Score = 27.7 bits (60), Expect(2) = 0.11
 Identities = 13/22 (59%), Positives = 15/22 (68%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYA 3840
            +R  VG  V LQGN DP AL+A
Sbjct: 253  ARARVGAKVALQGNFDPNALFA 274

 Score = 27.3 bits (59), Expect(3) = 5e-04
 Identities = 14/28 (50%), Positives = 17/28 (60%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A  F   C SP+   E+TLQ
Sbjct: 11   EYRATRARAGSFMGLCTSPDYATEVTLQ 38

 Score = 23.1 bits (48), Expect(3) = 5e-04
 Identities = 9/9 (100%), Positives = 9/9 (100%)
 Frame = +3

Query: 1833 MRQAGRYLP 1859
            MRQAGRYLP
Sbjct: 2    MRQAGRYLP 10
>gi|15792567|ref|NP_282390.1|   uroporphyrinogen decarboxylase [Campylobacter jejuni]
 gi|24211637|sp|Q9PN54|DCUP_CAMJE   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|11267841|pir||E81331   uroporphyrinogen decarboxylase (EC 4.1.1.37) Cj1243 [imported] -
            Campylobacter jejuni (strain NCTC 11168)
 gi|6968676|emb|CAB73497.1|   uroporphyrinogen decarboxylase [Campylobacter jejuni subsp. jejuni
            NCTC 11168]
          Length = 340

 Score = 80.9 bits (198), Expect = 2e-13
 Identities = 53/162 (32%), Positives = 77/162 (47%)
 Frame = +1

Query: 2422 LPLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGR 2601
            +PL+ +GM +    G+GP F  P+   +DLE+L D +    +L YV+ A+ LTR++L+  
Sbjct: 75   VPLE-MGMNLRFEKGEGPVFGNPISTLEDLEKL-DDQNAHKKLNYVYDALKLTREKLSQN 132

Query: 2602 VPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGG 2781
              LIGF G+P               W +                         TYM+EG 
Sbjct: 133  KALIGFCGSP---------------WTI------------------------ATYMIEGS 153

Query: 2782 GSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGA 2907
            GS   A+ K+ LYQ P+  H++L  LT  L  YL  Q+ AGA
Sbjct: 154  GSKNYAKCKKMLYQNPELLHKILNKLTQVLKLYLEEQIKAGA 195

 Score = 40.4 bits (93), Expect = 0.30
 Identities = 16/26 (61%), Positives = 20/26 (76%)
 Frame = +3

Query: 1782 FLRAAWGEETDYTPVWCMRQAGRYLP 1859
            F+ A + + T YTP+W MRQAGRYLP
Sbjct: 3    FIDACFKKPTPYTPIWMMRQAGRYLP 28

 Score = 32.0 bits (71), Expect(2) = 1.1
 Identities = 16/22 (72%), Positives = 18/22 (81%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQP+    +DAAIIFSDILVVP
Sbjct: 55   LQPIDILDVDAAIIFSDILVVP 76

 Score = 25.4 bits (54), Expect(2) = 1.1
 Identities = 13/42 (30%), Positives = 20/42 (47%)
 Frame = +1

Query: 1930 LWRASRLSPVFPLYAEFRETRAAQDFFSTCRSPEACCELTLQ 2055
            +W   +     P Y E R  + A DF S C+  +   E++LQ
Sbjct: 17   IWMMRQAGRYLPEYMEVR--KQAGDFLSLCKDYKKASEVSLQ 56
>gi|37524498|ref|NP_927842.1|   uroporphyrinogen decarboxylase [Photorhabdus luminescens subsp.
            laumondii TTO1]
 gi|36783922|emb|CAE12784.1|   uroporphyrinogen decarboxylase [Photorhabdus luminescens subsp.
            laumondii TTO1]
          Length = 354

 Score = 80.9 bits (198), Expect = 2e-13
 Identities = 55/161 (34%), Positives = 75/161 (46%), Gaps = 2/161 (1%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLR--DPEVVASELGYVFQAITLTRQRLAGRVP 2607
            A+G+ +    G+GP F  P+    D+E+L   DPE+   EL YV  A+   R+ LAG+VP
Sbjct: 84   AMGLGLYFEAGEGPRFKSPVFSRADVEKLPVPDPEM---ELSYVTDAVRAIRKALAGQVP 140

Query: 2608 LIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGS 2787
            LIGF+G+P  W  A                                     TYMVEGG S
Sbjct: 141  LIGFSGSP--WTLA-------------------------------------TYMVEGGSS 161

Query: 2788 STMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                + K+ +Y  P   H LL  L D+++ YL  Q+ AGAQ
Sbjct: 162  KAFTKIKKMMYAEPTVMHLLLDKLADSVILYLNAQIKAGAQ 202

 Score = 49.7 bits (117), Expect = 5e-04
 Identities = 29/67 (43%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L    E I Q V  +L  FG    ++ NLGHG++ D+ PEH G FV+AVHK
Sbjct: 288  LQGNMDPSMLYASPERIEQEVSTILQGFGTGSGHVFNLGHGIHQDILPEHAGVFVEAVHK 347

Query: 4314 HSRLLRQ 4334
             S    Q
Sbjct: 348  LSAKYHQ 354

 Score = 47.8 bits (112), Expect(2) = 8e-07
 Identities = 21/31 (67%), Positives = 23/31 (74%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND +LRA   +  D TPVW MRQAGRYLP
Sbjct: 4    LKNDRYLRALLRQSVDVTPVWMMRQAGRYLP 34

 Score = 37.4 bits (85), Expect = 2.5
 Identities = 20/41 (48%), Positives = 25/41 (60%)
 Frame = +2

Query: 2069 KRGKDLCLQSAT*QPVSCFLQPLRRFLLDAAIIFSDILVVP 2191
            K G  + L   T       LQPL+R+ LDAAI+FSDIL +P
Sbjct: 42   KAGDFIALCKNTELACEVTLQPLQRYPLDAAILFSDILTIP 82

 Score = 34.7 bits (78), Expect(2) = 0.002
 Identities = 28/78 (35%), Positives = 33/78 (42%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSS 3954
            +R  VG  V LQGN+DP  LYAS       +  +L       G       VFN  L    
Sbjct: 278  ARRRVGNKVALQGNMDPSMLYASPERIEQEVSTILQGFGTGSG------HVFN--LGHGI 329

Query: 3955 HLYTISPRKTGLFVAVVH 4008
            H   I P   G+FV  VH
Sbjct: 330  H-QDILPEHAGVFVEAVH 346

 Score = 32.0 bits (71), Expect(2) = 0.002
 Identities = 15/33 (45%), Positives = 20/33 (60%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            +FAK G   LE +A+ G + +GLDWT     AR
Sbjct: 247  LFAKGGGQWLEAMAETGCDALGLDWTTDIADAR 279

 Score = 30.8 bits (68), Expect(2) = 8e-07
 Identities = 14/28 (50%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF + C++ E  CE+TLQ
Sbjct: 35   EYQATRAKAGDFIALCKNTELACEVTLQ 62
>gi|28198490|ref|NP_778804.1|   uroporphyrinogen decarboxylase [Xylella fastidiosa Temecula1]
 gi|32129491|sp|Q87DV0|DCUP_XYLFT   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|28056574|gb|AAO28453.1|   uroporphyrinogen decarboxylase [Xylella fastidiosa Temecula1]
          Length = 354

 Score = 80.9 bits (198), Expect = 2e-13
 Identities = 51/159 (32%), Positives = 74/159 (46%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+E+  + G+GP   +P+R+   + +L  P++  +EL YV  A+ L R+ L   VPLI
Sbjct: 82   AMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDM-ETELRYVMDAVRLIRKELDNSVPLI 140

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                      YM+EGG S  
Sbjct: 141  GFSGSP--WTLA-------------------------------------CYMIEGGSSKE 161

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
             A+ K   +  P   HQLL  +TDA++ YL  Q  AGAQ
Sbjct: 162  YARIKAMAFNAPDVLHQLLNTVTDAVISYLAAQRAAGAQ 200

 Score = 45.1 bits (105), Expect = 0.012
 Identities = 20/31 (64%), Positives = 22/31 (70%)
 Frame = +3

Query: 1767 LKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            LKND  LRA   +  D TP+W MRQAGRYLP
Sbjct: 2    LKNDRLLRALRRDTVDRTPIWLMRQAGRYLP 32

 Score = 40.0 bits (92), Expect = 0.39
 Identities = 16/30 (53%), Positives = 23/30 (76%)
 Frame = +3

Query: 4233 YIANLGHGLYPDMDPEHVGAFVDAVHKHSR 4322
            ++ NLGHG+ P M+P+HV A V+AV + SR
Sbjct: 324  HVFNLGHGMTPGMNPDHVSALVEAVQRLSR 353

 Score = 40.0 bits (92), Expect(2) = 0.002
 Identities = 18/22 (81%), Positives = 21/22 (95%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRRF LDAAI+FSDIL++P
Sbjct: 59   LQPLRRFPLDAAILFSDILMIP 80

 Score = 38.5 bits (88), Expect = 1.1
 Identities = 18/52 (34%), Positives = 31/52 (59%)
 Frame = +3

Query: 3279 ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG 3434
            ALQ+F++  G L P ++  F+LPY+  +A++++   R  G    P+V  G G
Sbjct: 201  ALQVFDTWGGILSPTMYRTFSLPYLTRIARELE---RGTGTEHTPLVLFGKG 249

 Score = 26.6 bits (57), Expect(2) = 0.002
 Identities = 14/45 (31%), Positives = 20/45 (44%)
 Frame = +1

Query: 1921 RGGLWRASRLSPVFPLYAEFRETRAAQDFFSTCRSPEACCELTLQ 2055
            R  +W   +     P Y   R+   A  F    ++PE  CE+TLQ
Sbjct: 18   RTPIWLMRQAGRYLPEYRAARQH--AGSFLKMAKTPELACEITLQ 60
>gi|15640359|ref|NP_229986.1|   uroporphyrinogen decarboxylase [Vibrio cholerae O1 biovar eltor str.
            N16961]
 gi|11267825|pir||C82335   uroporphyrinogen decarboxylase VC0332 [imported] - Vibrio cholerae
            (strain N16961 serogroup O1)
 gi|9654747|gb|AAF93505.1|   uroporphyrinogen decarboxylase [Vibrio cholerae O1 biovar eltor str.
            N16961]
          Length = 359

 Score = 77.4 bits (189), Expect = 2e-12
 Identities = 50/159 (31%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+  + D++++  P+    EL YV  A+   R+ L G VPLI
Sbjct: 88   AMGLGLRFAAGEGPVFERPITCKADVDKIGIPDP-EGELQYVMNAVRQIRKDLQGEVPLI 146

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 147  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 167

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              + K+ +Y  P   H LL  L D+++ YL  Q+ AGAQ
Sbjct: 168  FTKIKKMMYSEPTVLHALLDKLADSVISYLNAQIKAGAQ 206

 Score = 52.4 bits (124), Expect(3) = 2e-13
 Identities = 23/32 (71%), Positives = 25/32 (78%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  DYTPVW MRQAGRYLP
Sbjct: 7    ELKNDRYLRALLKQPVDYTPVWMMRQAGRYLP 38

 Score = 44.3 bits (103), Expect = 0.021
 Identities = 25/64 (39%), Positives = 36/64 (56%), Gaps = 2/64 (3%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVH 4310
            L G    S L  P   I + V  +L  FG     ++ NLGHG++ D+ PE+ G FV+AVH
Sbjct: 292  LQGNMDPSILYAPAPRIREEVASILAGFGQGGTGHVFNLGHGIHLDVPPENAGVFVEAVH 351

Query: 4311 KHSR 4322
            + S+
Sbjct: 352  ELSK 355

 Score = 39.7 bits (91), Expect(3) = 2e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRRF LDAAI+FSDIL +P
Sbjct: 65   LQPLRRFPLDAAILFSDILTIP 86

 Score = 35.0 bits (79), Expect(2) = 0.002
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 2/35 (5%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWT--VAPKKAR 3677
            +F K+G   LE++A  G + VGLDWT  +A  KAR
Sbjct: 251  LFTKNGGMWLEQIAATGCDAVGLDWTINIADAKAR 285

 Score = 31.6 bits (70), Expect(2) = 0.002
 Identities = 26/74 (35%), Positives = 31/74 (41%)
 Frame = +1

Query: 3787 VGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSSHLYT 3966
            VG  V LQGN+DP  LYA     R  +  +L               VFN  L    HL  
Sbjct: 286  VGDKVALQGNMDPSILYAPAPRIREEVASILAGFGQGG-----TGHVFN--LGHGIHL-D 337

Query: 3967 ISPRKTGLFVAVVH 4008
            + P   G+FV  VH
Sbjct: 338  VPPENAGVFVEAVH 351

 Score = 28.5 bits (62), Expect(3) = 2e-13
 Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A DF + C++ E   E+TLQ
Sbjct: 39   EYRATRAQAGDFMALCKNAELASEVTLQ 66
>gi|23814028|sp|Q9KV26|DCUP_VIBCH   Uroporphyrinogen decarboxylase (URO-D) (UPD)
          Length = 355

 Score = 77.4 bits (189), Expect = 2e-12
 Identities = 50/159 (31%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+  + D++++  P+    EL YV  A+   R+ L G VPLI
Sbjct: 84   AMGLGLRFAAGEGPVFERPITCKADVDKIGIPDP-EGELQYVMNAVRQIRKDLQGEVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
              + K+ +Y  P   H LL  L D+++ YL  Q+ AGAQ
Sbjct: 164  FTKIKKMMYSEPTVLHALLDKLADSVISYLNAQIKAGAQ 202

 Score = 52.4 bits (124), Expect(3) = 2e-13
 Identities = 23/32 (71%), Positives = 25/32 (78%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  DYTPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLKQPVDYTPVWMMRQAGRYLP 34

 Score = 44.3 bits (103), Expect = 0.021
 Identities = 25/64 (39%), Positives = 36/64 (56%), Gaps = 2/64 (3%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR--YIANLGHGLYPDMDPEHVGAFVDAVH 4310
            L G    S L  P   I + V  +L  FG     ++ NLGHG++ D+ PE+ G FV+AVH
Sbjct: 288  LQGNMDPSILYAPAPRIREEVASILAGFGQGGTGHVFNLGHGIHLDVPPENAGVFVEAVH 347

Query: 4311 KHSR 4322
            + S+
Sbjct: 348  ELSK 351

 Score = 39.7 bits (91), Expect(3) = 2e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRRF LDAAI+FSDIL +P
Sbjct: 61   LQPLRRFPLDAAILFSDILTIP 82

 Score = 35.0 bits (79), Expect(2) = 0.002
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 2/35 (5%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWT--VAPKKAR 3677
            +F K+G   LE++A  G + VGLDWT  +A  KAR
Sbjct: 247  LFTKNGGMWLEQIAATGCDAVGLDWTINIADAKAR 281

 Score = 31.6 bits (70), Expect(2) = 0.002
 Identities = 26/74 (35%), Positives = 31/74 (41%)
 Frame = +1

Query: 3787 VGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSSHLYT 3966
            VG  V LQGN+DP  LYA     R  +  +L               VFN  L    HL  
Sbjct: 282  VGDKVALQGNMDPSILYAPAPRIREEVASILAGFGQGG-----TGHVFN--LGHGIHL-D 333

Query: 3967 ISPRKTGLFVAVVH 4008
            + P   G+FV  VH
Sbjct: 334  VPPENAGVFVEAVH 347

 Score = 28.5 bits (62), Expect(3) = 2e-13
 Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E+R TRA A DF + C++ E   E+TLQ
Sbjct: 35   EYRATRAQAGDFMALCKNAELASEVTLQ 62
>gi|15834174|ref|NP_312947.1|   uroporphyrinogen decarboxylase [Escherichia coli O157:H7]
 gi|23813992|sp|Q8X6X5|DCUP_ECO57   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|25291010|pir||H91243   uroporphyrinogen decarboxylase [imported] - Escherichia coli (strain
            O157:H7, substrain RIMD 0509952)
 gi|13364396|dbj|BAB38343.1|   uroporphyrinogen decarboxylase [Escherichia coli O157:H7]
          Length = 354

 Score = 78.2 bits (191), Expect = 1e-12
 Identities = 53/159 (33%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+  + D+++L  P+    ELGYV  A+   R+ L G VPLI
Sbjct: 84   AMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDP-EDELGYVMNAVRTIRRELKGEVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K+ +Y  PQA H LL  L  ++  YL  Q+ AGAQ
Sbjct: 164  FTVIKKMMYADPQALHALLDKLAKSVALYLNAQIKAGAQ 202

 Score = 49.3 bits (116), Expect(3) = 2e-13
 Identities = 22/32 (68%), Positives = 24/32 (75%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  D TPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLRQPVDVTPVWMMRQAGRYLP 34

 Score = 47.8 bits (112), Expect = 0.002
 Identities = 26/62 (41%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L  P   I + V  +L  FG    ++ NLGHG++ D+ PEH G FV+AVH+
Sbjct: 288  LQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHR 347

Query: 4314 HS 4319
             S
Sbjct: 348  LS 349

 Score = 38.9 bits (89), Expect(3) = 2e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRR+ LDAAI+FSDIL VP
Sbjct: 61   LQPLRRYPLDAAILFSDILTVP 82

 Score = 32.3 bits (72), Expect(3) = 2e-13
 Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF S C++ E  CE+TLQ
Sbjct: 35   EYKATRAQAGDFMSLCKNAELACEVTLQ 62

 Score = 32.0 bits (71), Expect(2) = 0.041
 Identities = 26/78 (33%), Positives = 32/78 (41%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSS 3954
            +R  VG  V LQGN+DP  LYA        +  +L       G       VFN  L    
Sbjct: 278  ARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEG------HVFN--LGHGI 329

Query: 3955 HLYTISPRKTGLFVAVVH 4008
            H   + P   G+FV  VH
Sbjct: 330  H-QDVPPEHAGVFVEAVH 346

 Score = 30.4 bits (67), Expect(2) = 0.041
 Identities = 14/33 (42%), Positives = 19/33 (57%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            +F K G   LE +A+ G + +GLDWT     AR
Sbjct: 247  LFTKGGGQWLEAMAETGCDALGLDWTTDIADAR 279
>gi|16131827|ref|NP_418425.1|   uroporphyrinogen decarboxylase [Escherichia coli K12]
 gi|1352226|sp|P29680|DCUP_ECOLI   Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|7436556|pir||H65206   uroporphyrinogen decarboxylase (EC 4.1.1.37) - Escherichia coli
            (strain K-12)
 gi|2367337|gb|AAC76971.1|   uroporphyrinogen decarboxylase [Escherichia coli K12]
          Length = 354

 Score = 78.2 bits (191), Expect = 1e-12
 Identities = 53/159 (33%), Positives = 72/159 (45%)
 Frame = +1

Query: 2434 ALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLI 2613
            A+G+ +    G+GP F  P+  + D+++L  P+    ELGYV  A+   R+ L G VPLI
Sbjct: 84   AMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDP-EDELGYVMNAVRTIRRELKGEVPLI 142

Query: 2614 GFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVXXXXXXXXXXXXXXXMTYMVEGGGSST 2793
            GF+G+P  W  A                                     TYMVEGG S  
Sbjct: 143  GFSGSP--WTLA-------------------------------------TYMVEGGSSKA 163

Query: 2794 MAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ 2910
                K+ +Y  PQA H LL  L  ++  YL  Q+ AGAQ
Sbjct: 164  FTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQ 202

 Score = 49.3 bits (116), Expect(3) = 2e-13
 Identities = 22/32 (68%), Positives = 24/32 (75%)
 Frame = +3

Query: 1764 ELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP 1859
            ELKND +LRA   +  D TPVW MRQAGRYLP
Sbjct: 3    ELKNDRYLRALLRQPVDVTPVWMMRQAGRYLP 34

 Score = 47.8 bits (112), Expect = 0.002
 Identities = 26/62 (41%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
 Frame = +3

Query: 4137 LAGPPVASALLVPQEEIGQLVKQMLDDFGPHR-YIANLGHGLYPDMDPEHVGAFVDAVHK 4313
            L G    S L  P   I + V  +L  FG    ++ NLGHG++ D+ PEH G FV+AVH+
Sbjct: 288  LQGNMDPSMLYAPPARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHR 347

Query: 4314 HS 4319
             S
Sbjct: 348  LS 349

 Score = 38.9 bits (89), Expect(3) = 2e-13
 Identities = 18/22 (81%), Positives = 20/22 (90%)
 Frame = +2

Query: 2126 LQPLRRFLLDAAIIFSDILVVP 2191
            LQPLRR+ LDAAI+FSDIL VP
Sbjct: 61   LQPLRRYPLDAAILFSDILTVP 82

 Score = 32.3 bits (72), Expect(3) = 2e-13
 Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
 Frame = +1

Query: 1975 EFRETRA-AQDFFSTCRSPEACCELTLQ 2055
            E++ TRA A DF S C++ E  CE+TLQ
Sbjct: 35   EYKATRAQAGDFMSLCKNAELACEVTLQ 62

 Score = 32.0 bits (71), Expect(2) = 0.041
 Identities = 26/78 (33%), Positives = 32/78 (41%)
 Frame = +1

Query: 3775 SRECVGKTVTLQGNLDPCALYASEVTARAPLCVLLLCTPVACGCIILCALVFNVCLSFSS 3954
            +R  VG  V LQGN+DP  LYA        +  +L       G       VFN  L    
Sbjct: 278  ARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEG------HVFN--LGHGI 329

Query: 3955 HLYTISPRKTGLFVAVVH 4008
            H   + P   G+FV  VH
Sbjct: 330  H-QDVPPEHAGVFVEAVH 346

 Score = 30.4 bits (67), Expect(2) = 0.041
 Identities = 14/33 (42%), Positives = 19/33 (57%)
 Frame = +3

Query: 3579 IFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR 3677
            +F K G   LE +A+ G + +GLDWT     AR
Sbjct: 247  LFTKGGGQWLEAMAETGCDALGLDWTTDIADAR 279
  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF
    Posted date:  Nov 24, 2003 12:35 AM
  Number of letters in database: 504,792,447
  Number of sequences in database:  1,544,637
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 460,766,415
Number of Sequences: 1544637
Number of extensions: 11433435
Number of successful extensions: 34058
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 25246
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 33960
length of database: 504,792,447
effective HSP length: 137
effective length of database: 293,177,178
effective search space used: 400773202326
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)