EMBL:HS307871
ID   HS307871   standard; DNA; HUM; 4514 BP.
XX
AC   U30787; X06048;
XX
SV   U30787.1
XX
DT   18-MAY-1996 (Rel. 47, Created)
DT   30-JUN-1999 (Rel. 60, Last updated, Version 2)
XX
DE   Human uroporphyrinogen decarboxylase (URO-D) gene, complete cds.
XX
KW   .
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Primates; Catarrhini; Hominidae; Homo.
XX
RN   [1]
RP   785-1143
RX   MEDLINE; 88015599.
RA   Romana M., Dubart A., Beaupain D., Chabret C., Goossens M., Romeo P.H.;
RT   "Structure of the gene for human uroporphyrinogen decarboxylase";
RL   Nucleic Acids Res. 15(18):7343-7356(1987).
XX
RN   [2]
RP   1-4514
RX   MEDLINE; 96220222.
RA   Moran-Jimenez M.J., Ged C., Romana M., Enriquez De Salamanca R., Taieb A.,
RA   Topi G., D'Alessandro L., de Verneuil H.;
RT   "Uroporphyrinogen decarboxylase: complete human gene sequence and molecular
RT   study of three families with hepatoerythropoietic porphyria";
RL   Am. J. Hum. Genet. 58(4):712-721(1996).
XX
RN   [3]
RP   1-4514
RA   Romana M., Ged C., Verneuil H.;
RT   ;
RL   Submitted (30-JUN-1995) to the EMBL/GenBank/DDBJ databases.
RL   Cecile Ged, Biochimie Medicale et Moleculaire, University of Bordeaux II,
RL   146 rue Leo Saignat, Bordeaux, France
XX
DR   EPD; EP17059; HS_DCUP.
DR   SWISS-PROT; P06132; DCUP_HUMAN.
XX
CC   On May 17, 1996 this sequence version replaced gi:37613.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..4514
FT                   /db_xref="taxon:9606"
FT                   /organism="Homo sapiens"
FT   protein_bind    1028..1037
FT                   /bound_moiety="Sp1"
FT   TATA_signal     1066..1073
FT   mRNA            join(1089..1126,1748..1860,1976..2055,2132..2194,
FT                   2434..2631,2749..2910,3279..3416,3576..3676,3780..3846,
FT                   4179..4514)
FT                   /gene="URO-D"
FT                   /product="uroporphyrinogen decarboxylase"
FT   gene            1089..4514
FT                   /gene="URO-D"
FT   CDS             join(1107..1126,1748..1860,1976..2055,2132..2194,
FT                   2434..2631,2749..2910,3279..3416,3576..3676,3780..3846,
FT                   4179..4340)
FT                   /codon_start=1
FT                   /db_xref="SWISS-PROT:P06132"
FT                   /gene="URO-D"
FT                   /product="uroporphyrinogen decarboxylase"
FT                   /protein_id="AAC50482.1"
FT                   /translation="MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPE
FT                   FRETRAAQDFFSTCRSPEACCELTLQPLRRFLLDAAIIFSDILVVPQALGMEVTMVPGK
FT                   GPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMT
FT                   YMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAG
FT                   HLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVG
FT                   LDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHG
FT                   LYPDMDPEHVGAFVDAVHKHSRLLRQN"
XX
SQ   Sequence 4514 BP; 984 A; 1159 C; 1197 G; 1174 T; 0 other;
     aagcttcgta agcacctctc gcggcacgaa agccagcgct gcctaggcgc cgcccggcgc        60
     gaggctctca cctctgccaa gaagcgcacc ggcccagcag ctgccggggg gactccagca       120
     ccgcgccggg ccatggaccc gccatgagtc agctggcgcg accgcggaca gagcttccca       180
     ccacgccctt ccccgccttt ggccagcctt tgccgtatgt tctggactaa gcgcacccca       240
     gctctcactg tattggactg tgtactccca cactcaacca tattacttat ctctgtgcca       300
     ccctaaccca gccgaccaaa cccaagattg gtgattgcta cctgatcaat ctccctctct       360
     ccatttcctt gtgactacca ttttatctct actgctacta ccctcattca agtcaccatt       420
     ctagctagcc tgggtcattg ccaacagtca tttttctggt tcttcggcct gctgtttttc       480
     ctcccactcc cagcgaatct gctggactcc ctatcctatg ggtggtgtga ttaaagtgtt       540
     tgagacaatg gccccttccc ctgccactga caggagtctt gagtcattag ggttgagttc       600
     tgtttgacac tcctaatccc aaggacactg gagatcatta ttcattttaa tgtgattgct       660
     gatttctgtt tccccagtct tgtagctcct taaaggctgg ggtgtcttga gcagagctaa       720
     cctctgcacc tactataggt ccaggctata gtatggacct ggctggataa gactgttggt       780
     atcatagttg ggacttgcgc caagctccgg atacccagac tgtcagatga gaacaaattc       840
     ctcatgtcac cgtaagatac atttacagcg gagttttctt ttgggccttt gttgtttcgt       900
     cgctacagca aactttacgg tgaaaaaagg taggggtcta cggcagcagc agggcagccc       960
     tggagctgtc gctggagtcc gatcatgtga tcttcaacat ggcgacgctc ttggttccct      1020
     acagaaaggg gcggagcctg gactgggggg caggctcaga ttcaggttaa attgtggatt      1080
     gagctcgcag ttacagacag ctgaccatgg aagcgaatgg gttggggtga gttctccaga      1140
     gcacgcggtg tggctagccg ggcttctaat ttgagtcttc caactcagga ctctatccct      1200
     ctactcccct ttccccaccc tggagaacct cccaacctga actccgttag ctggatcctg      1260
     aatcctaaaa ccatggattt ttgagatgtt catcccaggg ccttaattca agggatgcct      1320
     caggatttcc aaccaggatc ttcattctgg gaccatcaac tctgatccct ctttatcccc      1380
     cagcctgggt atttctcagc ccctgaacca gcccagtgac atttcccggt ttctgaggct      1440
     cactagttcg aagaccccca aactatcctt agtgggcctt cattccctcc ccccagtccc      1500
     tctggttgct tcgagcttgg aagagtagag actaagtgga gggaagaggc cccagggcgg      1560
     gcccttctgg agtttgtgca ctgataggca gagaggaggc ggaacgggcg gaaagccagg      1620
     gtttgggagc tggcctggag gaggtaggat agcggtcctg gactgaatcg gccttatgaa      1680
     cccgcgcttt ccccagccgt ccaacgtagc atactgacac ctacccccac ccccacctga      1740
     tcgccagacc tcagggtttt ccggagctga agaatgacac attcctgcga gcagcctggg      1800
     gagaggaaac agactacact cccgtttggt gcatgcgcca ggcaggccgt tacttaccag      1860
     gtaagagtca gggtctggaa atctagataa aactccggag gagaaaagtt ttcgaggggc      1920
     aggggagggc tctggagggc ctcaaggctg agccctgtct tccctctgta tgcagagttt      1980
     agggaaaccc gggctgccca ggactttttc agcacgtgtc gctctcctga ggcctgctgt      2040
     gaactgactc tgcaggtgag gggtccacaa aagagggaaa gatttatgcc ttcagtctgc      2100
     cacctagcaa cctgtctcct gtttcctaca gccactgcgt cgcttccttc tggatgctgc      2160
     catcattttc tccgacatcc ttgttgtacc ccaggtaccc actcaaacct gatcctagaa      2220
     tataatccaa ggacgccttg aaaatccttc tatcagtcca gtcaaggttt acaataagca      2280
     cttatcctaa ctggatcgag ggaaaaacta aggttgaaag aaatggagtt tggcagagtt      2340
     ttattctcct tttccttcct cctggaatga gctgaacaga acctttcctc ctggattcca      2400
     ttttgggaac ccagatgttt tctccccctc caggcactgg gcatggaggt gaccatggta      2460
     cctggcaaag gacccagctt cccagagcca ttaagagaag agcaggacct agaacgccta      2520
     cgggatccag aagtggtagc ctctgagcta ggctatgtgt tccaagccat cacccttacc      2580
     cgacaacgac tggctggacg tgtgccgctg attggctttg ctggtgcccc agtaatgtgg      2640
     gacagggcag ggactcgggg cgcggggaga tcactctgga aggtctgggg tagacaaaag      2700
     gaagggtcag tctggcttct gtgacaccat ctttctatcc ttctctagtg gaccctgatg      2760
     acatacatgg ttgagggtgg tggctcaagc accatggctc aggccaagcg ctggctctat      2820
     cagagacctc aggctagtca ccagctgctt cgcatcctca ctgatgctct ggtcccatat      2880
     ctggtaggac aagtggtggc tggtgcccag gtgagtcctg agagagagag aaataggctg      2940
     ggatttggtc tgtaaggccg agaagcaaga gtgtcctaaa cctgagaggg caggggtctt      3000
     aatgctaggg atgaaagaac cttggcctcc agtgatctag ctgagcagcc aagcccatcc      3060
     tgacactgac agtggggctt aatgctctaa gtattcagac accaaagtta gtgctgggat      3120
     ctgaggaaag taaatttttt tttttttaat tactgggttt ttagggtcag gcagtatcag      3180
     ggattgaagt catttgggga aaattgaggt ggattttgta tgtgggggaa acttcctctt      3240
     tgtgtgttac atatttttct tcaccatacc ctaactaggc attgcagctg tttgagtccc      3300
     atgcagggca tcttggccca cagctcttca acaagtttgc actgccttac atccgtgatg      3360
     tggccaagca agtgaaggcc aggttgcggg aggcaggcct ggcaccagtg cccatggtga      3420
     ggattgggat gggttgagtg aaggtggtcc tgtggagctt tcaggctaag tcctgcatgg      3480
     actggagtga ccactggagg gcagcagaag tacagtcaag aaagattagt ggttgtagca      3540
     aggccctctg tagcctgaga tctgcttttt tctagatcat ctttgctaag gatgggcatt      3600
     ttgccctgga ggagctggcc caagctggct atgaggtggt tgggcttgac tggacagtgg      3660
     ccccaaagaa agcccggtaa gccatggaag ggtgaggcct tgaggttgag gtgggggtgt      3720
     tggctggggg agctgccatg tatgcagtta ccagaacgtg gcgctggctt tgcttccagg      3780
     gagtgtgtgg ggaagacggt gacattgcag ggcaacctgg acccctgtgc cttgtatgca      3840
     tctgaggtaa cagccagggc ccctctgtgt gtcctgttac tgtgcactcc tgtggcctgt      3900
     ggttgtatta ttctgtgtgc acttgttttt aatgtctgtc tgtccttttc ttctcatctg      3960
     tacaccataa gccctagaaa gaccggactt tttgttgctg ttgttcattt gtgtttatgc      4020
     ttcatgcctg ggtccatact agggatctat aaattttatt gaatgactga ataacactga      4080
     gttagaagca tgcctaccat atgcgtttct actagtatat atagggagga caaaggcttg      4140
     ctggtcctcc tgtagccagt gccctgttgg tcccccagga ggagatcggg cagttggtga      4200
     agcagatgct ggatgacttt ggaccacatc gctacattgc caacttgggc catgggcttt      4260
     atcctgacat ggacccagaa catgtgggcg cctttgtgga tgctgtgcat aaacactcac      4320
     gtctgcttcg acagaactga ccgtatacct ttaccctcaa gtaccactaa cacagatgat      4380
     tgatcgtttc caggacaata aaagtttcgg agttgaacct attgtgtagt tttgtttgtg      4440
     aaagattgtc ccatatcctc agttcttctt agcctctgtc tccttccctg ggaccctctc      4500
     atatcctctt atag                                                        4514
//