General Information
Primary Accession #	U30787
Accession #	U30787 X06048
Entry Name	EMBL:U30787
Molecule Type	genomic DNA
Sequence Length	4514
Entry Division	HUM
Sequence Version	U30787.1
Creation Date	18-MAY-1996
Modification Date	30-JUN-1999
Description
Description	Human uroporphyrinogen decarboxylase (URO-D) gene, complete cds.
Keywords	.;
Organism	Homo sapiens (human)
Organism Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; Homo.
References
1.	Romana,M.; Dubart,A.; Beaupain,D.; Chabret,C.; Goossens,M.; Romeo,P.H.; Structure of the gene for human uroporphyrinogen decarboxylase Nucleic Acids Res. 15(18):7343-7356 (1987)
	Pubmed	3658695
	Position	785-1143
2.	Moran-Jimenez,M.J.; Ged,C.; Romana,M.; Enriquez De Salamanca,R.; Taieb,A.; Topi,G.; D'Alessandro,L.; de Verneuil,H.; Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria Am. J. Hum. Genet. 58(4):712-721 (1996)
	Pubmed	8644733
	Position	1-4514
3.	Romana,M.; Ged,C.; Verneuil,H.; Submitted (30-JUN-1995) to the EMBL/GenBank/DDBJ databases. Cecile Ged, Biochimie Medicale et Moleculaire, University of Bordeaux II, 146 rue Leo Saignat, Bordeaux, France
	Position	1-4514
Database Cross-references
EPD	EP17059; HS_UROD.
Features
Key	Location		Qualifier	Value
source	1..4514		organism	Homo sapiens
			mol_type	genomic DNA
			db_xref	taxon:9606
protein_bind	1028..1037		bound_moiety	Sp1
tata_signal	1066..1073
mrna	join(1089..1126, 1748..1860, 1976..2055, 2132..2194, 2434..2631, 2749..2910, 3279..3416, 3576..3676, 3780..3846, 4179..4514)		gene	URO-D
			product	uroporphyrinogen decarboxylase
gene	1089..4514		gene	URO-D
cds	join(1107..1126, 1748..1860, 1976..2055, 2132..2194, 2434..2631, 2749..2910, 3279..3416, 3576..3676, 3780..3846, 4179..4340)		codon_start	1
			gene	URO-D
			product	uroporphyrinogen decarboxylase
			db_xref	GDB:119628
			db_xref	GOA:P06132
			db_xref	HGNC:12591
			db_xref	InterPro:IPR000257
			db_xref	InterPro:IPR006361
			db_xref	PDB:1JPH
			db_xref	PDB:1JPI
			db_xref	PDB:1JPK
			db_xref	PDB:1R3Q
			db_xref	PDB:1R3R
			db_xref	PDB:1R3S
			db_xref	PDB:1R3T
			db_xref	PDB:1R3V
			db_xref	PDB:1R3W
			db_xref	PDB:1R3Y
			db_xref	PDB:1URO
			db_xref	UniProtKB/Swiss-Prot:P06132
			protein_id	AAC50482.1
			translation	>AAC50482 MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR SPEACCELTLQPLRRFLLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLER LRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRW LYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDV AKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVT LQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKH SRLLRQN
Sequence
Characteristics	Length: 4514 BP, A Count:984, C Count:1159, G Count:1197, T Count:1174, Others Count:0
Sequence	>embl|U30787|U30787 Human uroporphyrinogen decarboxylase (URO-D) gene, complete cds. ... aagcttcgtaagcacctctcgcggcacgaaagccagcgctgcctaggcgccgcccggcgc gaggctctcacctctgccaagaagcgcaccggcccagcagctgccggggggactccagca ccgcgccgggccatggacccgccatgagtcagctggcgcgaccgcggacagagcttccca ccacgcccttccccgcctttggccagcctttgccgtatgttctggactaagcgcacccca gctctcactgtattggactgtgtactcccacactcaaccatattacttatctctgtgcca ccctaacccagccgaccaaacccaagattggtgattgctacctgatcaatctccctctct ccatttccttgtgactaccattttatctctactgctactaccctcattcaagtcaccatt ctagctagcctgggtcattgccaacagtcatttttctggttcttcggcctgctgtttttc ctcccactcccagcgaatctgctggactccctatcctatgggtggtgtgattaaagtgtt tgagacaatggccccttcccctgccactgacaggagtcttgagtcattagggttgagttc tgtttgacactcctaatcccaaggacactggagatcattattcattttaatgtgattgct gatttctgtttccccagtcttgtagctccttaaaggctggggtgtcttgagcagagctaa cctctgcacctactataggtccaggctatagtatggacctggctggataagactgttggt atcatagttgggacttgcgccaagctccggatacccagactgtcagatgagaacaaattc ctcatgtcaccgtaagatacatttacagcggagttttcttttgggcctttgttgtttcgt cgctacagcaaactttacggtgaaaaaaggtaggggtctacggcagcagcagggcagccc tggagctgtcgctggagtccgatcatgtgatcttcaacatggcgacgctcttggttccct acagaaaggggcggagcctggactggggggcaggctcagattcaggttaaattgtggatt gagctcgcagttacagacagctgaccatggaagcgaatgggttggggtgagttctccaga gcacgcggtgtggctagccgggcttctaatttgagtcttccaactcaggactctatccct ctactcccctttccccaccctggagaacctcccaacctgaactccgttagctggatcctg aatcctaaaaccatggatttttgagatgttcatcccagggccttaattcaagggatgcct caggatttccaaccaggatcttcattctgggaccatcaactctgatccctctttatcccc cagcctgggtatttctcagcccctgaaccagcccagtgacatttcccggtttctgaggct cactagttcgaagacccccaaactatccttagtgggccttcattccctccccccagtccc tctggttgcttcgagcttggaagagtagagactaagtggagggaagaggccccagggcgg gcccttctggagtttgtgcactgataggcagagaggaggcggaacgggcggaaagccagg gtttgggagctggcctggaggaggtaggatagcggtcctggactgaatcggccttatgaa cccgcgctttccccagccgtccaacgtagcatactgacacctacccccacccccacctga tcgccagacctcagggttttccggagctgaagaatgacacattcctgcgagcagcctggg gagaggaaacagactacactcccgtttggtgcatgcgccaggcaggccgttacttaccag gtaagagtcagggtctggaaatctagataaaactccggaggagaaaagttttcgaggggc aggggagggctctggagggcctcaaggctgagccctgtcttccctctgtatgcagagttt agggaaacccgggctgcccaggactttttcagcacgtgtcgctctcctgaggcctgctgt gaactgactctgcaggtgaggggtccacaaaagagggaaagatttatgccttcagtctgc cacctagcaacctgtctcctgtttcctacagccactgcgtcgcttccttctggatgctgc catcattttctccgacatccttgttgtaccccaggtacccactcaaacctgatcctagaa tataatccaaggacgccttgaaaatccttctatcagtccagtcaaggtttacaataagca cttatcctaactggatcgagggaaaaactaaggttgaaagaaatggagtttggcagagtt ttattctccttttccttcctcctggaatgagctgaacagaacctttcctcctggattcca ttttgggaacccagatgttttctccccctccaggcactgggcatggaggtgaccatggta cctggcaaaggacccagcttcccagagccattaagagaagagcaggacctagaacgccta cgggatccagaagtggtagcctctgagctaggctatgtgttccaagccatcacccttacc cgacaacgactggctggacgtgtgccgctgattggctttgctggtgccccagtaatgtgg gacagggcagggactcggggcgcggggagatcactctggaaggtctggggtagacaaaag gaagggtcagtctggcttctgtgacaccatctttctatccttctctagtggaccctgatg acatacatggttgagggtggtggctcaagcaccatggctcaggccaagcgctggctctat cagagacctcaggctagtcaccagctgcttcgcatcctcactgatgctctggtcccatat ctggtaggacaagtggtggctggtgcccaggtgagtcctgagagagagagaaataggctg ggatttggtctgtaaggccgagaagcaagagtgtcctaaacctgagagggcaggggtctt aatgctagggatgaaagaaccttggcctccagtgatctagctgagcagccaagcccatcc tgacactgacagtggggcttaatgctctaagtattcagacaccaaagttagtgctgggat ctgaggaaagtaaatttttttttttttaattactgggtttttagggtcaggcagtatcag ggattgaagtcatttggggaaaattgaggtggattttgtatgtgggggaaacttcctctt tgtgtgttacatatttttcttcaccataccctaactaggcattgcagctgtttgagtccc atgcagggcatcttggcccacagctcttcaacaagtttgcactgccttacatccgtgatg tggccaagcaagtgaaggccaggttgcgggaggcaggcctggcaccagtgcccatggtga ggattgggatgggttgagtgaaggtggtcctgtggagctttcaggctaagtcctgcatgg actggagtgaccactggagggcagcagaagtacagtcaagaaagattagtggttgtagca aggccctctgtagcctgagatctgcttttttctagatcatctttgctaaggatgggcatt ttgccctggaggagctggcccaagctggctatgaggtggttgggcttgactggacagtgg ccccaaagaaagcccggtaagccatggaagggtgaggccttgaggttgaggtgggggtgt tggctgggggagctgccatgtatgcagttaccagaacgtggcgctggctttgcttccagg gagtgtgtggggaagacggtgacattgcagggcaacctggacccctgtgccttgtatgca tctgaggtaacagccagggcccctctgtgtgtcctgttactgtgcactcctgtggcctgt ggttgtattattctgtgtgcacttgtttttaatgtctgtctgtccttttcttctcatctg tacaccataagccctagaaagaccggactttttgttgctgttgttcatttgtgtttatgc ttcatgcctgggtccatactagggatctataaattttattgaatgactgaataacactga gttagaagcatgcctaccatatgcgtttctactagtatatatagggaggacaaaggcttg ctggtcctcctgtagccagtgccctgttggtcccccaggaggagatcgggcagttggtga agcagatgctggatgactttggaccacatcgctacattgccaacttgggccatgggcttt atcctgacatggacccagaacatgtgggcgcctttgtggatgctgtgcataaacactcac gtctgcttcgacagaactgaccgtatacctttaccctcaagtaccactaacacagatgat tgatcgtttccaggacaataaaagtttcggagttgaacctattgtgtagttttgtttgtg aaagattgtcccatatcctcagttcttcttagcctctgtctccttccctgggaccctctc atatcctcttatag