BLASTX 2.2.14 [Apr-09-2006]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman 
(1997), "Gapped BLAST and PSI-BLAST: a new generation of 
protein database search programs", Nucleic Acids Res. 25:3389-3402.

RID: 1147098735-27427-188273306547.BLASTQ1


Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
           3,632,049 sequences; 1,248,697,171 total letters
 
If you have any problems or questions with the results of this search 
please refer to the BLAST FAQs
Taxonomy reports


Query=  embl|U30787|U30787 Human uroporphyrinogen decarboxylase (URO-D) gene, 
complete cds. ...
Length=4514

Related Structures

                                                                   Score     E
Sequences producing significant alignments:                        (Bits)  Value

gi|55959134|emb|CAI16439.1|  uroporphyrinogen decarboxylase [Homo   221    3e-55
gi|76614224|ref|XP_883416.1|  PREDICTED: similar to Uroporphyr...   220    5e-55  
gi|30582313|gb|AAP35383.1|  uroporphyrinogen decarboxylase [Ho...   215    1e-53  
gi|31323304|gb|AAP44118.1|  uroporphyrinogen decarboxylase [Ho...   215    1e-53  
gi|71051616|ref|NP_000365.3|  uroporphyrinogen decarboxylase [...   215    1e-53  
gi|30584783|gb|AAP36644.1|  Homo sapiens uroporphyrinogen deca...   215    1e-53
gi|60834750|gb|AAX37109.1|  uroporphyrinogen decarboxylase [synth   215    1e-53
gi|40889570|pdb|1R3V|A  Chain A, Uroporphyrinogen Decarboxylas...   215    1e-53  
gi|40889569|pdb|1R3T|A  Chain A, Uroporphyrinogen Decarboxylas...   215    1e-53  
gi|40889567|pdb|1R3R|A  Chain A, Uroporphyrinogen Decarboxylase W   215    1e-53  
gi|18158959|pdb|1JPI|A  Chain A, Phe232leu Mutant Of Human Uro...   215    1e-53  
gi|18158958|pdb|1JPH|A  Chain A, Ile260thr Mutant Of Human Uro...   215    1e-53  
gi|55586239|ref|XP_513127.1|  PREDICTED: uroporphyrinogen decarbo   214    4e-53  
gi|40889571|pdb|1R3W|A  Chain A, Uroporphyrinogen Decarboxylas...   214    4e-53  
gi|18158960|pdb|1JPK|A  Chain A, Gly156asp Mutant Of Human Uro...   213    8e-53  
gi|340181|gb|AAA61258.1|  uroporphyrinogen decarboxylase (EC 4.1.   211    3e-52  
gi|73977146|ref|XP_861894.1|  PREDICTED: similar to Uroporphyr...   210    5e-52  
gi|55726782|emb|CAH90152.1|  hypothetical protein [Pongo pygma...   208    2e-51
gi|340183|gb|AAB59456.1|  uroporphyrinogen decarboxylase            206    8e-51  
gi|59891403|ref|NP_001012341.1|  uroporphyrinogen decarboxylas...   206    1e-50  
gi|76614234|ref|XP_883601.1|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|76614232|ref|XP_883566.1|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|76614230|ref|XP_883536.1|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|76614222|ref|XP_581108.2|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|76614218|ref|XP_883301.1|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|73977148|ref|XP_861922.1|  PREDICTED: similar to Uroporphyr...   206    1e-50  
gi|73977150|ref|XP_532602.2|  PREDICTED: similar to Uroporphyr...   205    2e-50  
gi|73977140|ref|XP_861812.1|  PREDICTED: similar to Uroporphyr...   204    2e-50  
gi|14198090|gb|AAH08109.1|  Uroporphyrinogen decarboxylase [Mu...   198    2e-48  
gi|76614228|ref|XP_883500.1|  PREDICTED: similar to Uroporphyr...   198    2e-48  
gi|73977142|ref|XP_861837.1|  PREDICTED: similar to Uroporphyr...   197    4e-48  
gi|6678517|ref|NP_033504.1|  uroporphyrinogen decarboxylase [M...   197    5e-48  
gi|62649478|ref|XP_342888.2|  PREDICTED: uroporphyrinogen decarbo   196    8e-48  
gi|225691|prf||1310344A  decarboxylase,uroporphyrinogen             189    1e-45
gi|5524747|emb|CAB50784.1|  uroporphyrinogen decarboxylase [Ra...   187    4e-45  
gi|50751502|ref|XP_422430.1|  PREDICTED: similar to Uroporphyr...   159    1e-36  
gi|46250159|gb|AAH68896.1|  MGC83088 protein [Xenopus laevis]       157    5e-36  
gi|73977144|ref|XP_861870.1|  PREDICTED: similar to Uroporphyr...   131    1e-35  
gi|57032914|gb|AAH88815.1|  LOC496978 protein [Xenopus tropicalis   155    2e-35  
gi|49116745|gb|AAH73643.1|  MGC82980 protein [Xenopus laevis]       155    2e-35  
gi|89886127|ref|NP_001011486.2|  hypothetical protein LOC49697...   155    2e-35  
gi|76614220|ref|XP_883334.1|  PREDICTED: similar to Uroporphyr...   127    5e-35  
gi|47216605|emb|CAG10903.1|  unnamed protein product [Tetraodon n   150    5e-34
gi|55959136|emb|CAI16441.1|  uroporphyrinogen decarboxylase [Homo  87.0    5e-34
gi|18859531|ref|NP_571422.1|  uroporphyrinogen decarboxylase [...   147    6e-33  
gi|62204806|gb|AAH92696.1|  Urod protein [Danio rerio]              145    1e-32  
gi|79160119|gb|AAI08076.1|  Urod protein [Danio rerio]              145    1e-32  
gi|72004376|ref|XP_784308.1|  PREDICTED: similar to uroporphyr...   134    3e-29  
gi|66801513|ref|XP_629682.1|  uroporphyrinogen decarboxylase [...   131    2e-28  
gi|58262678|ref|XP_568749.1|  uroporphyrinogen decarboxylase [...   125    2e-26  
gi|50259723|gb|EAL22393.1|  hypothetical protein CNBB5660 [Cry...   125    2e-26
gi|83815293|ref|YP_445821.1|  uroporphyrinogen decarboxylase [...   122    2e-25  
gi|50289463|ref|XP_447163.1|  unnamed protein product [Candida...   119    1e-24  
gi|4140696|gb|AAD04168.1|  uroporphyrinogen decarboxylase [Homo s   118    2e-24  
gi|50311181|ref|XP_455614.1|  unnamed protein product [Kluyver...   114    3e-23  
gi|44985657|gb|AAS54281.1|  AGL210Cp [Ashbya gossypii ATCC 108...   112    2e-22
gi|76154669|gb|AAX26107.2|  SJCHGC03658 protein [Schistosoma japo   111    3e-22
gi|58394273|ref|XP_320631.2|  ENSANGP00000021292 [Anopheles ga...   109    1e-21  
gi|21430840|gb|AAM51098.1|  SD19419p [Drosophila melanogaster]      107    5e-21
gi|19921920|ref|NP_610501.1|  Updo CG1818-PA [Drosophila melan...   107    5e-21  
gi|54636745|gb|EAL26148.1|  GA14829-PA [Drosophila pseudoobscura]   106    1e-20
gi|91095059|ref|XP_972457.1|  PREDICTED: similar to CG1818-PA [Tr   104    3e-20
gi|4140695|gb|AAD04167.1|  uroporphyrinogen decarboxylase [Homo s   104    4e-20  
gi|46108958|ref|XP_381537.1|  hypothetical protein FG01361.1 [...   104    4e-20  
gi|3915203|sp|O18601|DCUP_DROVI  Uroporphyrinogen decarboxylas...   103    9e-20
gi|39951959|ref|XP_363696.1|  hypothetical protein MG01622.4 [Mag   101    4e-19  
gi|89296700|gb|EAR94688.1|  uroporphyrinogen decarboxylase fam...  90.5    6e-16
gi|90416469|ref|ZP_01224400.1|  uroporphyrinogen decarboxylase...  89.4    1e-15
gi|76884769|gb|ABA59450.1|  Uroporphyrinogen decarboxylase Hem...  84.7    3e-14  
gi|91777014|ref|YP_546770.1|  uroporphyrinogen decarboxylase [...  84.3    4e-14
gi|87120721|ref|ZP_01076614.1|  uroporphyrinogen decarboxylase...  54.3    1e-13
gi|49531531|emb|CAG69243.1|  uroporphyrinogen decarboxylase [A...  49.3    1e-13  
gi|91228705|ref|ZP_01262618.1|  uroporphyrinogen decarboxylase...  53.5    1e-13
gi|75854223|ref|ZP_00761930.1|  COG0407: Uroporphyrinogen-III dec  53.5    1e-13
gi|33564264|emb|CAE43556.1|  uroporphyrinogen decarboxylase [B...  82.8    1e-13  
gi|76876712|emb|CAI87934.1|  uroporphyrinogen decarboxylase [P...  48.9    2e-13  
gi|90581308|ref|ZP_01237105.1|  uroporphyrinogen decarboxylase...  52.4    2e-13
gi|88795719|ref|ZP_01111411.1|  uroporphyrinogen decarboxylase...  49.7    2e-13
gi|28807942|dbj|BAC61179.1|  uroporphyrinogen decarboxylase [V...  53.5    2e-13  
gi|91791832|ref|YP_561483.1|  uroporphyrinogen decarboxylase [...  48.9    2e-13
gi|69949848|ref|ZP_00637812.1|  Uroporphyrinogen decarboxylase...  49.3    2e-13
gi|89093495|ref|ZP_01166443.1|  Uroporphyrinogen decarboxylase...  51.2    2e-13
gi|78366223|ref|ZP_00836505.1|  Uroporphyrinogen decarboxylase...  49.3    3e-13
gi|68546226|ref|ZP_00585774.1|  Uroporphyrinogen decarboxylase...  49.3    3e-13
gi|86131005|ref|ZP_01049604.1|  uroporphyrinogen decarboxylase...  48.9    3e-13
gi|89899631|ref|YP_522102.1|  uroporphyrinogen decarboxylase [...  81.3    4e-13  
gi|409791|gb|AAC43095.1|  uroporphyrinogen decarboxylase [Escheri  49.7    4e-13
gi|68542591|ref|ZP_00582318.1|  Uroporphyrinogen decarboxylase...  50.4    4e-13
gi|9654747|gb|AAF93505.1|  uroporphyrinogen decarboxylase [Vib...  52.4    5e-13  
gi|15834174|ref|NP_312947.1|  uroporphyrinogen decarboxylase [...  49.3    5e-13  
gi|16131827|ref|NP_418425.1|  uroporphyrinogen decarboxylase [...  49.3    5e-13  
gi|26111199|gb|AAN83382.1|  Uroporphyrinogen decarboxylase [Es...  49.3    5e-13  
gi|82778827|ref|YP_405176.1|  uroporphyrinogen decarboxylase [...  49.3    5e-13  
gi|12518926|gb|AAG59194.1|  uroporphyrinogen decarboxylase [Es...  49.3    5e-13  
gi|75236727|ref|ZP_00720800.1|  COG0407: Uroporphyrinogen-III ...  49.3    5e-13
gi|83569015|ref|ZP_00920478.1|  COG0407: Uroporphyrinogen-III ...  49.3    5e-13
gi|29540889|gb|AAO89833.1|  uroporphyrinogen decarboxylase [Co...  80.5    6e-13  
gi|94490989|ref|ZP_01298210.1|  hypothetical protein CburD_010...  80.5    6e-13
gi|30248462|ref|NP_840532.1|  Uroporphyrinogen decarboxylase (...  52.8    2e-12  
gi|82701838|ref|YP_411404.1|  uroporphyrinogen decarboxylase [...  76.3    1e-11  

Alignments

>gi|55959134|emb|CAI16439.1|  uroporphyrinogen decarboxylase [Homo sapiens]
Length=193

 Score =  221 bits (562),  Expect = 3e-55
 Identities = 123/168 (73%), Positives = 124/168 (73%), Gaps = 39/168 (23%)
 Frame = +1

Query  2407  EPRCFLPLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQ  2586
             E  C L LQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQ
Sbjct  63    EACCELTLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQ  122

Query  2587  RLAGRVPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTY  2766
             RLAGRVPLIGFAGAP               W +                        MTY
Sbjct  123   RLAGRVPLIGFAGAP---------------WTL------------------------MTY  143

Query  2767  MVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             MVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  144   MVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  191


 Score = 87.0 bits (214),  Expect(2) = 2e-27
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 62.4 bits (150),  Expect(2) = 2e-27
 Identities = 28/30 (93%), Positives = 28/30 (93%), Gaps = 0/30 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQVRG  2064
             EFRETRAAQDFFSTCRSPEACCELTLQ  G
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQALG  74


>gi|76614224|ref|XP_883416.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 4 [Bos taurus]
Length=358

 Score =  220 bits (560),  Expect = 5e-55
 Identities = 119/167 (71%), Positives = 123/167 (73%), Gaps = 39/167 (23%)
 Frame = +1

Query  2410  PRCFLPLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQR  2589
             PRCFLP QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQR
Sbjct  76    PRCFLPCQALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQR  135

Query  2590  LAGRVPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYM  2769
             LAGRVPLIGFAGAP               W +                        MTYM
Sbjct  136   LAGRVPLIGFAGAP---------------WTL------------------------MTYM  156

Query  2770  VEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             VEGGGSSTM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  157   VEGGGSSTMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  203


 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  204   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  250

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  251   ----------------------------------------IFAKDGHFALEELAQAGYEV  270

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  271   VGLDWTVAPEKAR  283


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  282   ARERVGKTVTLQGNLDPCALYASE  305


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  300   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  358


 Score = 48.1 bits (113),  Expect(2) = 9e-09
 Identities = 22/29 (75%), Positives = 23/29 (79%), Gaps = 0/29 (0%)
 Frame = +1

Query  1774  MTHSCEQPGERKQTTLPFGACARQAVTYQ  1860
             MT SCEQ GE+KQTTL FGAC RQ  TYQ
Sbjct  1     MTPSCEQRGEKKQTTLLFGACGRQDATYQ  29


 Score = 38.5 bits (88),  Expect(2) = 9e-09
 Identities = 20/27 (74%), Positives = 21/27 (77%), Gaps = 0/27 (0%)
 Frame = +2

Query  1973  QSLGKPGLPRTFSARVALLRPAVN*LC  2053
             QSLGK GLPRTFSA VA  +PAVN  C
Sbjct  29    QSLGKLGLPRTFSAPVAPQKPAVNLPC  55


 Score = 46.2 bits (108),  Expect = 0.014
 Identities = 26/53 (49%), Positives = 30/53 (56%), Gaps = 3/53 (5%)
 Frame = +3

Query  2046  DSAGEGSTKEGKIYAFSLPPSNLSP---VSYSHCVASFWMLPSFSPTSLLYPR  2195
             D+  +   K G    FS P +   P   +  SHCVAS WMLPS SPTSL YPR
Sbjct  25    DATYQSLGKLGLPRTFSAPVAPQKPAVNLPCSHCVASLWMLPSSSPTSLSYPR  77


>gi|30582313|gb|AAP35383.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|60655571|gb|AAX32349.1|  uroporphyrinogen decarboxylase [synthetic construct]
 gi|60655569|gb|AAX32348.1|  uroporphyrinogen decarboxylase [synthetic construct]
 gi|12804699|gb|AAH01778.1|  UROD protein [Homo sapiens]
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-38
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 48.9 bits (115),  Expect(2) = 2e-38
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQ NLDPCALYASE
Sbjct  291   ARECVGKTVTLQVNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|31323304|gb|AAP44118.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151851|gb|AAD04590.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151849|gb|AAD04589.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151847|gb|AAD04588.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151845|gb|AAD04587.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151843|gb|AAD04586.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151841|gb|AAD04585.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151839|gb|AAD04584.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151837|gb|AAD04583.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151835|gb|AAD04582.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151833|gb|AAD04581.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151831|gb|AAD04580.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151829|gb|AAD04579.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151827|gb|AAD04578.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151825|gb|AAD04577.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151823|gb|AAD04576.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151821|gb|AAD04575.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151819|gb|AAD04574.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151817|gb|AAD04573.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151815|gb|AAD04572.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|4151813|gb|AAD04571.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|1322019|gb|AAC50482.1|  uroporphyrinogen decarboxylase
 gi|1418944|emb|CAA61540.1|  uroporphyrinogen decarboxylase [Homo sapiens]
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 8e-35
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 8e-35
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 47.0 bits (110),  Expect(3) = 8e-35
 Identities = 23/23 (100%), Positives = 23/23 (100%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRFLLDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFLLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|71051616|ref|NP_000365.3|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|55959135|emb|CAI16440.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|49457067|emb|CAG46854.1|  UROD [Homo sapiens]
 gi|48146069|emb|CAG33257.1|  UROD [Homo sapiens]
 gi|2507533|sp|P06132|DCUP_HUMAN  Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|2905794|gb|AAC03563.1|  uroporphyrinogen decarboxylase [Homo sapiens]
 gi|40889572|pdb|1R3Y|A  Chain A, Uroporphyrinogen Decarboxylase In Complex With Coproporphyrinogen-Iii
 gi|40889566|pdb|1R3Q|A  Chain A, Uroporphyrinogen Decarboxylase In Complex With Coproporphyrinogen-I
 gi|3660278|pdb|1URO|A  Chain A, Uroporphyrinogen Decarboxylase
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|30584783|gb|AAP36644.1|  Homo sapiens uroporphyrinogen decarboxylase [synthetic construct]
 gi|61372969|gb|AAX43947.1|  uroporphyrinogen decarboxylase [synthetic construct]
Length=368

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-38
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 48.9 bits (115),  Expect(2) = 2e-38
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQ NLDPCALYASE
Sbjct  291   ARECVGKTVTLQVNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|60834750|gb|AAX37109.1|  uroporphyrinogen decarboxylase [synthetic construct]
Length=368

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|40889570|pdb|1R3V|A  Chain A, Uroporphyrinogen Decarboxylase Single Mutant D86e In 
Complex With Coproporphyrinogen-I
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 2e-33
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 2e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 42.7 bits (99),  Expect(3) = 2e-33
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFS+ILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSEILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|40889569|pdb|1R3T|A  Chain A, Uroporphyrinogen Decarboxylase Single Mutant D86g In 
Complex With Coproporphyrinogen-Iii
 gi|40889568|pdb|1R3S|A  Chain A, Uroporphyrinogen Decarboxylase Single Mutant D86g In 
Complex With Coproporphyrinogen-I
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 3e-33
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 3e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 41.6 bits (96),  Expect(3) = 3e-33
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFS ILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSGILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|40889567|pdb|1R3R|A  Chain A, Uroporphyrinogen Decarboxylase With Mutation D86n
Length=367

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 2e-33
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 2e-33
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 42.4 bits (98),  Expect(3) = 2e-33
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFS+ILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSNILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|18158959|pdb|1JPI|A  Chain A, Phe232leu Mutant Of Human Urod, Human Uroporphyrinogen 
Iii Decarboxylase
Length=388

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  113   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  172

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  173   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  193

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  194   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  233


 Score =  135 bits (340),  Expect(2) = 8e-39
 Identities = 78/133 (58%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNK ALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  234   ALQLFESHAGHLGPQLFNKLALPYIRDVAKQVKARLREAGLAPVPMI-------------  280

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  281   ----------------------------------------IFAKDGHFALEELAQAGYEV  300

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  301   VGLDWTVAPKKAR  313


 Score = 52.4 bits (124),  Expect(2) = 8e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  312   ARECVGKTVTLQGNLDPCALYASE  335


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  29    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  65


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  66    EFRETRAAQDFFSTCRSPEACCELTLQ  92


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  91    LQPLRRFPLDAAIIFSDILVVPQ  113


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  330   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  388


>gi|18158958|pdb|1JPH|A  Chain A, Ile260thr Mutant Of Human Urod, Human Uroporphyrinogen 
Iii Decarboxylase
Length=388

 Score =  215 bits (548),  Expect = 1e-53
 Identities = 119/160 (74%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  113   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  172

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  173   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  193

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  194   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  233


 Score =  136 bits (342),  Expect(2) = 5e-39
 Identities = 79/133 (59%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM              
Sbjct  234   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM--------------  279

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                    I FAKDGHFALEELAQAGYEV
Sbjct  280   ---------------------------------------ITFAKDGHFALEELAQAGYEV  300

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  301   VGLDWTVAPKKAR  313


 Score = 52.4 bits (124),  Expect(2) = 5e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  312   ARECVGKTVTLQGNLDPCALYASE  335


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  29    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  65


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  66    EFRETRAAQDFFSTCRSPEACCELTLQ  92


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  91    LQPLRRFPLDAAIIFSDILVVPQ  113


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  330   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  388


>gi|55586239|ref|XP_513127.1|  PREDICTED: uroporphyrinogen decarboxylase [Pan troglodytes]
Length=367

 Score =  214 bits (544),  Expect = 4e-53
 Identities = 118/160 (73%), Positives = 119/160 (74%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|40889571|pdb|1R3W|A  Chain A, Uroporphyrinogen Decarboxylase Y164f Mutant In Complex 
With Coproporphyrinogen-Iii
Length=367

 Score =  214 bits (544),  Expect = 4e-53
 Identities = 118/160 (73%), Positives = 120/160 (75%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MT+MVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTFMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|18158960|pdb|1JPK|A  Chain A, Gly156asp Mutant Of Human Urod, Human Uroporphyrinogen 
Iii Decarboxylase
Length=388

 Score =  213 bits (541),  Expect = 8e-53
 Identities = 118/160 (73%), Positives = 119/160 (74%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  113   QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  172

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFA AP               W +                        MTYMVEGGGSS
Sbjct  173   IGFADAP---------------WTL------------------------MTYMVEGGGSS  193

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  194   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  233


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  234   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  280

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  281   ----------------------------------------IFAKDGHFALEELAQAGYEV  300

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  301   VGLDWTVAPKKAR  313


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  312   ARECVGKTVTLQGNLDPCALYASE  335


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  29    PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  65


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  66    EFRETRAAQDFFSTCRSPEACCELTLQ  92


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  91    LQPLRRFPLDAAIIFSDILVVPQ  113


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  330   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  388


>gi|340181|gb|AAA61258.1|  uroporphyrinogen decarboxylase (EC 4.1.1.37)
Length=367

 Score =  211 bits (536),  Expect = 3e-52
 Identities = 117/160 (73%), Positives = 118/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVP KGPSFPEPLREEQDLE LRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPSKGPSFPEPLREEQDLEALRDPEVVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  212


 Score =  137 bits (346),  Expect(2) = 2e-39
 Identities = 79/133 (59%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 2e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|73977146|ref|XP_861894.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 5 [Canis familiaris]
Length=346

 Score =  210 bits (534),  Expect = 5e-52
 Identities = 116/168 (69%), Positives = 120/168 (71%), Gaps = 39/168 (23%)
 Frame = +1

Query  2407  EPRCFLPLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQ  2586
             E  C L LQALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ
Sbjct  63    EACCELTLQALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQ  122

Query  2587  RLAGRVPLIGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTY  2766
             RLAGRVPLIGFAGAP               W +                        MTY
Sbjct  123   RLAGRVPLIGFAGAP---------------WTL------------------------MTY  143

Query  2767  MVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             M+EGG SSTMAQAKRWLYQ+PQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  144   MIEGGSSSTMAQAKRWLYQKPQASHQLLRILTDALVPYLVGQVAAGAQ  191


 Score =  131 bits (330),  Expect(2) = 1e-35
 Identities = 74/133 (55%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPY+RDVAK+VKAR++EAGLAPVPM+             
Sbjct  192   ALQLFESHAGHLGPQLFNKFALPYVRDVAKRVKARVQEAGLAPVPMI-------------  238

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  239   ----------------------------------------IFAKDGHFALEELAQAGYEV  258

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  259   VGLDWTVAPEKAR  271


 Score = 45.4 bits (106),  Expect(2) = 1e-35
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  270   ARERVGKMVTLQGNLDPCALYASE  293


 Score = 83.2 bits (204),  Expect(2) = 7e-26
 Identities = 35/36 (97%), Positives = 36/36 (100%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             QGFPELKNDTFLRAAWGE+TDYTPVWCMRQAGRYLP
Sbjct  9     QGFPELKNDTFLRAAWGEDTDYTPVWCMRQAGRYLP  44


 Score = 61.2 bits (147),  Expect(2) = 7e-26
 Identities = 27/30 (90%), Positives = 28/30 (93%), Gaps = 0/30 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQVRG  2064
             EF+ETRAAQDFFSTCRSPEACCELTLQ  G
Sbjct  45    EFKETRAAQDFFSTCRSPEACCELTLQALG  74


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  288   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  346


>gi|55726782|emb|CAH90152.1|  hypothetical protein [Pongo pygmaeus]
 gi|75061970|sp|Q5RDK5|DCUP_PONPY  Uroporphyrinogen decarboxylase (URO-D) (UPD)
Length=367

 Score =  208 bits (529),  Expect = 2e-51
 Identities = 116/160 (72%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLE LRDPEVVASEL YVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREEQDLECLRDPEVVASELDYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score =  135 bits (341),  Expect(2) = 6e-39
 Identities = 78/133 (58%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 52.4 bits (124),  Expect(2) = 6e-39
 Identities = 23/24 (95%), Positives = 24/24 (100%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RECVGKTVTLQGNLDPCALYASE
Sbjct  291   ARECVGKTVTLQGNLDPCALYASE  314


 Score = 87.0 bits (214),  Expect(3) = 3e-33
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  8     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 58.2 bits (139),  Expect(3) = 3e-33
 Identities = 26/27 (96%), Positives = 26/27 (96%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCE TLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCEPTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 3e-33
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  118 bits (296),  Expect = 2e-24
 Identities = 55/59 (93%), Positives = 56/59 (94%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|340183|gb|AAB59456.1|  uroporphyrinogen decarboxylase
Length=161

 Score =  206 bits (524),  Expect = 8e-51
 Identities = 114/158 (72%), Positives = 116/158 (73%), Gaps = 39/158 (24%)
 Frame = +1

Query  2440  GMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF  2619
             GMEVTMVP KGPSFPEPLREEQDLE LRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF
Sbjct  1     GMEVTMVPSKGPSFPEPLREEQDLEALRDPEVVASELGYVFQAITLTRQRLAGRVPLIGF  60

Query  2620  AGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSSTMA  2799
             AGAP               W +                        MTYMVEGGGSSTMA
Sbjct  61    AGAP---------------WTL------------------------MTYMVEGGGSSTMA  81

Query  2800  QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV  2913
             QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ+
Sbjct  82    QAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQL  119


 Score = 92.0 bits (227),  Expect = 2e-16
 Identities = 44/44 (100%), Positives = 44/44 (100%), Gaps = 0/44 (0%)
 Frame = +3

Query  3285  QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM  3416
             QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM
Sbjct  118   QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM  161


>gi|59891403|ref|NP_001012341.1|  uroporphyrinogen decarboxylase [Ovis aries]
 gi|27527067|emb|CAC82649.1|  uroporphyrinogen decarboxylase [Ovis aries]
Length=367

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPATVASELGYVFQAITLTRQQLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  280   VGLDWTVAPEKAR  292


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  291   ARERVGKTVTLQGNLDPCALYASE  314


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|76614234|ref|XP_883601.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 9 [Bos taurus]
Length=292

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  127 bits (319),  Expect = 5e-27
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  280   VGLDWTVAPEKAR  292


>gi|76614232|ref|XP_883566.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 8 [Bos taurus]
Length=327

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  102 bits (254),  Expect = 2e-19
 Identities = 61/121 (50%), Positives = 67/121 (55%), Gaps = 53/121 (43%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  V  3641
             +
Sbjct  280   L  280


 Score = 99.8 bits (247),  Expect = 1e-18
 Identities = 48/58 (82%), Positives = 51/58 (87%), Gaps = 5/58 (8%)
 Frame = +3

Query  4179  EEIGQ-----LVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             EE+ Q     LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  270   EELAQAGYEVLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  327


>gi|76614230|ref|XP_883536.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 7 [Bos taurus]
Length=322

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  47    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  106

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  107   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  127

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  128   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  167


 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  168   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  214

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  215   ----------------------------------------IFAKDGHFALEELAQAGYEV  234

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  235   VGLDWTVAPEKAR  247


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  246   ARERVGKTVTLQGNLDPCALYASE  269


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  264   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  322


 Score = 44.3 bits (103),  Expect(2) = 0.008
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  25    LQPLRRFPLDAAIIFSDILVVPQ  47


 Score = 21.9 bits (45),  Expect(2) = 0.008
 Identities = 8/8 (100%), Positives = 8/8 (100%), Gaps = 0/8 (0%)
 Frame = +1

Query  2032  ACCELTLQ  2055
             ACCELTLQ
Sbjct  19    ACCELTLQ  26


>gi|76614222|ref|XP_581108.2|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 1 [Bos taurus]
Length=367

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  280   VGLDWTVAPEKAR  292


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  291   ARERVGKTVTLQGNLDPCALYASE  314


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|76614218|ref|XP_883301.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 2 [Bos taurus]
Length=279

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 113/160 (70%), Positives = 117/160 (73%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGGGSS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGGSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+QAKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  173   TMSQAKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  212


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  112 bits (281),  Expect = 1e-22
 Identities = 55/72 (76%), Positives = 63/72 (87%), Gaps = 5/72 (6%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPMVR+G+G      WS
Sbjct  213   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMVRMGVG-----QWS  267

Query  3459  FQAKSCMDWSDH  3494
             +Q KSCM+ SDH
Sbjct  268   YQVKSCMELSDH  279


>gi|73977148|ref|XP_861922.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 6 [Canis familiaris]
Length=321

 Score =  206 bits (523),  Expect = 1e-50
 Identities = 112/161 (69%), Positives = 117/161 (72%), Gaps = 39/161 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYM+EGG SS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMIEGGSSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV  2913
             TMAQAKRWLYQ+PQASHQLLRILTDALVPYLVGQV AGAQ+
Sbjct  173   TMAQAKRWLYQKPQASHQLLRILTDALVPYLVGQVAAGAQI  213


 Score = 83.2 bits (204),  Expect(3) = 2e-32
 Identities = 35/36 (97%), Positives = 36/36 (100%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             QGFPELKNDTFLRAAWGE+TDYTPVWCMRQAGRYLP
Sbjct  9     QGFPELKNDTFLRAAWGEDTDYTPVWCMRQAGRYLP  44


 Score = 59.7 bits (143),  Expect(3) = 2e-32
 Identities = 26/27 (96%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EF+ETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFKETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 2e-32
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  263   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  321


 Score = 70.9 bits (172),  Expect(2) = 2e-17
 Identities = 33/34 (97%), Positives = 34/34 (100%), Gaps = 0/34 (0%)
 Frame = +3

Query  3576  IIFAKDGHFALEELAQAGYEVVGLDWTVAPKKAR  3677
             IIFAKDGHFALEELAQAGYEVVGLDWTVAP+KAR
Sbjct  213   IIFAKDGHFALEELAQAGYEVVGLDWTVAPEKAR  246


 Score = 45.4 bits (106),  Expect(2) = 2e-17
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  245   ARERVGKMVTLQGNLDPCALYASE  268


>gi|73977150|ref|XP_532602.2|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 1 [Canis familiaris]
Length=364

 Score =  205 bits (521),  Expect = 2e-50
 Identities = 112/161 (69%), Positives = 117/161 (72%), Gaps = 39/161 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYM+EGG SS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMIEGGSSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV  2913
             TMAQAKRWLYQ+PQASHQLLRILTDALVPYLVGQV AGAQ+
Sbjct  173   TMAQAKRWLYQKPQASHQLLRILTDALVPYLVGQVAAGAQL  213


 Score =  128 bits (322),  Expect(2) = 1e-34
 Identities = 72/131 (54%), Positives = 78/131 (59%), Gaps = 53/131 (40%)
 Frame = +3

Query  3285  QLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSFQ  3464
             QLFESHAGHLGPQLFNKFALPY+RDVAK+VKAR++EAGLAPVPM+               
Sbjct  212   QLFESHAGHLGPQLFNKFALPYVRDVAKRVKARVQEAGLAPVPMI---------------  256

Query  3465  AKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVVG  3644
                                                   IFAKDGHFALEELAQAGYEVVG
Sbjct  257   --------------------------------------IFAKDGHFALEELAQAGYEVVG  278

Query  3645  LDWTVAPKKAR  3677
             LDWTVAP+KAR
Sbjct  279   LDWTVAPEKAR  289


 Score = 45.4 bits (106),  Expect(2) = 1e-34
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  288   ARERVGKMVTLQGNLDPCALYASE  311


 Score = 83.2 bits (204),  Expect(3) = 2e-32
 Identities = 35/36 (97%), Positives = 36/36 (100%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             QGFPELKNDTFLRAAWGE+TDYTPVWCMRQAGRYLP
Sbjct  9     QGFPELKNDTFLRAAWGEDTDYTPVWCMRQAGRYLP  44


 Score = 59.7 bits (143),  Expect(3) = 2e-32
 Identities = 26/27 (96%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EF+ETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFKETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 2e-32
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  306   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  364


>gi|73977140|ref|XP_861812.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 2 [Canis familiaris]
Length=332

 Score =  204 bits (520),  Expect = 2e-50
 Identities = 112/160 (70%), Positives = 116/160 (72%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  57    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL  116

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYM+EGG SS
Sbjct  117   IGFAGAP---------------WTL------------------------MTYMIEGGSSS  137

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQ+PQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  138   TMAQAKRWLYQKPQASHQLLRILTDALVPYLVGQVAAGAQ  177


 Score =  131 bits (330),  Expect(2) = 1e-35
 Identities = 74/133 (55%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPY+RDVAK+VKAR++EAGLAPVPM+             
Sbjct  178   ALQLFESHAGHLGPQLFNKFALPYVRDVAKRVKARVQEAGLAPVPMI-------------  224

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  225   ----------------------------------------IFAKDGHFALEELAQAGYEV  244

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  245   VGLDWTVAPEKAR  257


 Score = 45.4 bits (106),  Expect(2) = 1e-35
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  256   ARERVGKMVTLQGNLDPCALYASE  279


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  274   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  332


 Score = 59.7 bits (143),  Expect(3) = 7e-15
 Identities = 26/27 (96%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EF+ETRAAQDFFSTCRSPEACCELTLQ
Sbjct  10    EFKETRAAQDFFSTCRSPEACCELTLQ  36


 Score = 44.3 bits (103),  Expect(3) = 7e-15
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  35    LQPLRRFPLDAAIIFSDILVVPQ  57


 Score = 23.1 bits (48),  Expect(3) = 7e-15
 Identities = 9/9 (100%), Positives = 9/9 (100%), Gaps = 0/9 (0%)
 Frame = +3

Query  1833  MRQAGRYLP  1859
             MRQAGRYLP
Sbjct  1     MRQAGRYLP  9


>gi|14198090|gb|AAH08109.1|  Uroporphyrinogen decarboxylase [Mus musculus]
 gi|74192377|dbj|BAE43002.1|  unnamed protein product [Mus musculus]
Length=367

 Score =  198 bits (504),  Expect = 2e-48
 Identities = 109/160 (68%), Positives = 113/160 (70%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP   ASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGG SS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGSSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASH+LL ILTD LVPYL+GQV AGAQ
Sbjct  173   TMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQ  212


 Score =  124 bits (311),  Expect(2) = 2e-33
 Identities = 72/133 (54%), Positives = 78/133 (58%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 45.8 bits (107),  Expect(2) = 2e-33
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  291   ARERVGKAVTLQGNLDPCALYASE  314


 Score = 82.0 bits (201),  Expect(3) = 2e-32
 Identities = 35/36 (97%), Positives = 35/36 (97%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  9     QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 2e-32
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 2e-32
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  109 bits (272),  Expect = 1e-21
 Identities = 51/59 (86%), Positives = 54/59 (91%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QMLDDFGP RYIANLGHGLYPDMDPE VGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGRLVQQMLDDFGPQRYIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN  367


>gi|76614228|ref|XP_883500.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 6 [Bos taurus]
 gi|76614226|ref|XP_883454.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 5 [Bos taurus]
Length=272

 Score =  198 bits (504),  Expect = 2e-48
 Identities = 109/156 (69%), Positives = 113/156 (72%), Gaps = 39/156 (25%)
 Frame = +1

Query  2443  MEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFA  2622
             MEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPLIGFA
Sbjct  1     MEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPLIGFA  60

Query  2623  GAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSSTMAQ  2802
             GAP               W +                        MTYMVEGGGSSTM+Q
Sbjct  61    GAP---------------WTL------------------------MTYMVEGGGSSTMSQ  81

Query  2803  AKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             AKRWLYQRPQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  82    AKRWLYQRPQASHQLLRILTDALVPYLVGQVAAGAQ  117


 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  118   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  164

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  165   ----------------------------------------IFAKDGHFALEELAQAGYEV  184

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  185   VGLDWTVAPEKAR  197


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  196   ARERVGKTVTLQGNLDPCALYASE  219


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  214   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  272


>gi|73977142|ref|XP_861837.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 3 [Canis familiaris]
Length=272

 Score =  197 bits (501),  Expect = 4e-48
 Identities = 108/156 (69%), Positives = 112/156 (71%), Gaps = 39/156 (25%)
 Frame = +1

Query  2443  MEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFA  2622
             MEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPLIGFA
Sbjct  1     MEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPLIGFA  60

Query  2623  GAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSSTMAQ  2802
             GAP               W +                        MTYM+EGG SSTMAQ
Sbjct  61    GAP---------------WTL------------------------MTYMIEGGSSSTMAQ  81

Query  2803  AKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             AKRWLYQ+PQASHQLLRILTDALVPYLVGQV AGAQ
Sbjct  82    AKRWLYQKPQASHQLLRILTDALVPYLVGQVAAGAQ  117


 Score =  131 bits (330),  Expect(2) = 1e-35
 Identities = 74/133 (55%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPY+RDVAK+VKAR++EAGLAPVPM+             
Sbjct  118   ALQLFESHAGHLGPQLFNKFALPYVRDVAKRVKARVQEAGLAPVPMI-------------  164

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  165   ----------------------------------------IFAKDGHFALEELAQAGYEV  184

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  185   VGLDWTVAPEKAR  197


 Score = 45.4 bits (106),  Expect(2) = 1e-35
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  196   ARERVGKMVTLQGNLDPCALYASE  219


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  214   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  272


>gi|6678517|ref|NP_033504.1|  uroporphyrinogen decarboxylase [Mus musculus]
 gi|2501645|sp|P70697|DCUP_MOUSE  Uroporphyrinogen decarboxylase (URO-D) (UPD)
 gi|1498643|gb|AAB18294.1|  uroporphyrinogen decarboxylase
Length=367

 Score =  197 bits (500),  Expect = 5e-48
 Identities = 108/160 (67%), Positives = 113/160 (70%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALG+EVTMVPGKGPSFPEPLREE+DLERLRDP   ASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGIEVTMVPGKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGG SS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGSSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQRPQASH+LL ILTD LVPYL+GQV AGAQ
Sbjct  173   TMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQ  212


 Score =  124 bits (311),  Expect(2) = 2e-33
 Identities = 72/133 (54%), Positives = 78/133 (58%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 45.8 bits (107),  Expect(2) = 2e-33
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  291   ARERVGKAVTLQGNLDPCALYASE  314


 Score = 82.0 bits (201),  Expect(3) = 2e-32
 Identities = 35/36 (97%), Positives = 35/36 (97%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  9     QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 2e-32
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 2e-32
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  105 bits (263),  Expect = 1e-20
 Identities = 50/59 (84%), Positives = 53/59 (89%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QMLDDFGP R IANLGHGLYPDMDPE VGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGRLVQQMLDDFGPQRSIANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN  367


>gi|62649478|ref|XP_342888.2|  PREDICTED: uroporphyrinogen decarboxylase [Rattus norvegicus]
Length=367

 Score =  196 bits (498),  Expect = 8e-48
 Identities = 108/160 (67%), Positives = 114/160 (71%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGG SS
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGSSS  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQ+P ASH+LL ILTDALVPYL+GQV AGAQ
Sbjct  173   TMAQAKRWLYQKPLASHKLLGILTDALVPYLIGQVAAGAQ  212


 Score =  124 bits (311),  Expect(2) = 4e-34
 Identities = 72/133 (54%), Positives = 78/133 (58%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGLAPVPM+             
Sbjct  213   ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 47.8 bits (112),  Expect(2) = 4e-34
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  291   ARERVGKTVTLQGNLDPCALYASE  314


 Score = 82.0 bits (201),  Expect(3) = 3e-32
 Identities = 35/36 (97%), Positives = 35/36 (97%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  9     QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 3e-32
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 43.1 bits (100),  Expect(3) = 3e-32
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLR+F LDAAIIFSDILVVPQ
Sbjct  70    LQPLRKFPLDAAIIFSDILVVPQ  92


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  367


>gi|225691|prf||1310344A  decarboxylase,uroporphyrinogen
Length=367

 Score =  189 bits (479),  Expect = 1e-45
 Identities = 105/160 (65%), Positives = 110/160 (68%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QAL MEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALAMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGG   
Sbjct  152   IGFAGAP---------------WTL------------------------MTYMVEGGSFK  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQ+P ASH+LL ILT ALVPYL+GQV AGAQ
Sbjct  173   TMAQAKRWLYQKPVASHKLLGILTHALVPYLIGQVAAGAQ  212


 Score =  118 bits (295),  Expect(2) = 1e-31
 Identities = 69/133 (51%), Positives = 76/133 (57%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGL  +PM+             
Sbjct  213   ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLTRMPMI-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  260   ----------------------------------------IFAKDGHFALEELAQAGYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  280   VGLDWTVAPKKAR  292


 Score = 45.4 bits (106),  Expect(2) = 1e-31
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQG LDPCALYASE
Sbjct  291   AREPVGKTVTLQGELDPCALYASE  314


 Score = 77.0 bits (188),  Expect(3) = 1e-30
 Identities = 34/36 (94%), Positives = 34/36 (94%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FPELKNDTFLRAA GEETDYTPVWCMRQAGRYLP
Sbjct  9     QNFPELKNDTFLRAATGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-30
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 43.1 bits (100),  Expect(3) = 1e-30
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQP+RRF LDAAIIFSDILVVPQ
Sbjct  70    LQPVRRFPLDAAIIFSDILVVPQ  92


 Score =  109 bits (272),  Expect = 1e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAF+DAVHKHSRLLRQN
Sbjct  309   ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFLDAVHKHSRLLRQN  367


>gi|5524747|emb|CAB50784.1|  uroporphyrinogen decarboxylase [Rattus norvegicus]
 gi|416892|sp|P32362|DCUP_RAT  Uroporphyrinogen decarboxylase (URO-D) (UPD)
Length=364

 Score =  187 bits (475),  Expect = 4e-45
 Identities = 104/160 (65%), Positives = 110/160 (68%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QAL MEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQ+LAGRVPL
Sbjct  89    QALAMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPL  148

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGFAGAP               W +                        MTYMVEGG   
Sbjct  149   IGFAGAP---------------WTL------------------------MTYMVEGGSFK  169

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMAQAKRWLYQ+P ASH+LL ILT ALVPYL+GQV AGAQ
Sbjct  170   TMAQAKRWLYQKPVASHKLLGILTHALVPYLIGQVAAGAQ  209


 Score =  118 bits (295),  Expect(2) = 1e-31
 Identities = 69/133 (51%), Positives = 76/133 (57%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLG +LF+KFALPYIRDVAK+VKA L++AGL  +PM+             
Sbjct  210   ALQLFESHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLTRMPMI-------------  256

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  257   ----------------------------------------IFAKDGHFALEELAQAGYEV  276

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAPKKAR
Sbjct  277   VGLDWTVAPKKAR  289


 Score = 45.4 bits (106),  Expect(2) = 1e-31
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQG LDPCALYASE
Sbjct  288   AREPVGKTVTLQGELDPCALYASE  311


 Score = 82.0 bits (201),  Expect(3) = 2e-31
 Identities = 35/36 (97%), Positives = 35/36 (97%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     QNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  41


 Score = 59.7 bits (143),  Expect(3) = 2e-31
 Identities = 26/27 (96%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTL+
Sbjct  42    EFRETRAAQDFFSTCRSPEACCELTLE  68


 Score = 42.0 bits (97),  Expect(3) = 2e-31
 Identities = 20/23 (86%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             L+P+RRF LDAAIIFSDILVVPQ
Sbjct  67    LEPVRRFPLDAAIIFSDILVVPQ  89


 Score =  109 bits (272),  Expect = 1e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAF+DAVHKHSRLLRQN
Sbjct  306   ALYASEEEIGRLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFLDAVHKHSRLLRQN  364


>gi|50751502|ref|XP_422430.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) [Gallus gallus]
Length=373

 Score =  159 bits (401),  Expect = 1e-36
 Identities = 87/160 (54%), Positives = 103/160 (64%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEV MVPGKGP+FPEPL+E +DL +LR    V +ELGYVFQAITLTR  L G+VPL
Sbjct  97    QALGMEVVMVPGKGPTFPEPLKEVEDLLKLRQKVDVTAELGYVFQAITLTRHSLEGKVPL  156

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF+GAP               W +                        M+YMVEGGGS+
Sbjct  157   IGFSGAP---------------WTL------------------------MSYMVEGGGST  177

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TMA+AK WLY+ P+ASH+LLR+LTD +  YLVGQV AGAQ
Sbjct  178   TMAKAKSWLYRHPEASHRLLRLLTDVVTDYLVGQVAAGAQ  217


 Score = 75.1 bits (183),  Expect(3) = 5e-29
 Identities = 32/37 (86%), Positives = 36/37 (97%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+GFP+LKNDTFLRAA GEET++TPVWCMRQAGRYLP
Sbjct  13    PKGFPKLKNDTFLRAARGEETEHTPVWCMRQAGRYLP  49


 Score = 55.8 bits (133),  Expect(3) = 5e-29
 Identities = 24/27 (88%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFF TCRSP+ CCELTLQ
Sbjct  50    EFRETRAAQDFFDTCRSPKLCCELTLQ  76


 Score = 44.3 bits (103),  Expect(3) = 5e-29
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  75    LQPLRRFPLDAAIIFSDILVVPQ  97


 Score = 99.8 bits (247),  Expect(2) = 3e-24
 Identities = 55/133 (41%), Positives = 70/133 (52%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGP+ F +FALPYIRD+A+ VK++L+   L+ VPM+             
Sbjct  218   ALQLFESHAGHLGPEQFQEFALPYIRDIARDVKSKLKAEALSLVPMI-------------  264

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+AL +LAQAGYEV
Sbjct  265   ----------------------------------------VFAKDAHYALRDLAQAGYEV  284

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P++AR
Sbjct  285   VGLDWTIQPQEAR  297


 Score = 39.3 bits (90),  Expect(2) = 3e-24
 Identities = 18/22 (81%), Positives = 19/22 (86%), Gaps = 0/22 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYA  3840
             +R  VGK VTLQGNLDPCALYA
Sbjct  296   ARAQVGKGVTLQGNLDPCALYA  317


 Score = 93.6 bits (231),  Expect = 7e-17
 Identities = 44/70 (62%), Positives = 55/70 (78%), Gaps = 0/70 (0%)
 Frame = +3

Query  4128  GQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAV  4307
             G  L G     AL  P+E+IG+LVK+ML++FG  RYIANLGHGLYPDM+PEHVGAFV+AV
Sbjct  303   GVTLQGNLDPCALYAPKEKIGELVKKMLENFGTQRYIANLGHGLYPDMNPEHVGAFVEAV  362

Query  4308  HKHSRLLRQN  4337
             H HSR + ++
Sbjct  363   HAHSRHINKH  372


>gi|46250159|gb|AAH68896.1|  MGC83088 protein [Xenopus laevis]
Length=367

 Score =  157 bits (396),  Expect = 5e-36
 Identities = 85/160 (53%), Positives = 101/160 (63%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGME+ M PG+GP FPEPL+  QDL++LR    V+ ELGYVF+AITLTR +L G+VPL
Sbjct  93    QALGMEIRMEPGRGPVFPEPLQTPQDLQKLRSSVDVSEELGYVFRAITLTRHKLEGKVPL  152

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        MTYM+EGGGS+
Sbjct  153   IGFTGAP---------------WTL------------------------MTYMIEGGGSN  173

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM++AKRWLYQ P ASHQLL+ LTD +V YLVGQV AGAQ
Sbjct  174   TMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQ  213


 Score = 64.3 bits (155),  Expect(3) = 2e-25
 Identities = 28/37 (75%), Positives = 31/37 (83%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FP L NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  9     PECFPTLHNDTFLRAARGEECNHVPVWCMRQAGRYLP  45


 Score = 54.7 bits (130),  Expect(3) = 2e-25
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRA QDFF++CRSPE CCELTLQ
Sbjct  46    EFRETRAGQDFFASCRSPEICCELTLQ  72


 Score = 43.9 bits (102),  Expect(3) = 2e-25
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILV+PQ
Sbjct  71    LQPLRRFPLDAAIIFSDILVIPQ  93


 Score = 89.0 bits (219),  Expect(2) = 1e-21
 Identities = 49/133 (36%), Positives = 69/133 (51%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESHAG LGPQ F+ F+LPY++D++++VK +L+  GL  VPM+             
Sbjct  214   ALQVFESHAGCLGPQQFSDFSLPYLKDISRRVKHKLKAEGLNQVPMI-------------  260

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+ALE+L+Q+ YEV
Sbjct  261   ----------------------------------------VFAKDAHYALEDLSQSDYEV  280

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P++AR
Sbjct  281   VGLDWTIRPQEAR  293


 Score = 41.6 bits (96),  Expect(2) = 1e-21
 Identities = 18/24 (75%), Positives = 21/24 (87%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE  GK VTLQGN+DPCALYAS+
Sbjct  292   ARERTGKRVTLQGNMDPCALYASK  315


 Score = 75.1 bits (183),  Expect = 3e-11
 Identities = 33/54 (61%), Positives = 43/54 (79%), Gaps = 0/54 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSR  4322
             AL   + +I + VK+M++ FG   YIANLGHGLYPDMDP+HVGAF+ AVHK+S+
Sbjct  310   ALYASKGDIEKTVKKMIEGFGRRGYIANLGHGLYPDMDPDHVGAFISAVHKYSQ  363


>gi|73977144|ref|XP_861870.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 4 [Canis familiaris]
Length=313

 Score =  131 bits (330),  Expect(2) = 1e-35
 Identities = 74/133 (55%), Positives = 80/133 (60%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPY+RDVAK+VKAR++EAGLAPVPM+             
Sbjct  159   ALQLFESHAGHLGPQLFNKFALPYVRDVAKRVKARVQEAGLAPVPMI-------------  205

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  206   ----------------------------------------IFAKDGHFALEELAQAGYEV  225

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  226   VGLDWTVAPEKAR  238


 Score = 45.4 bits (106),  Expect(2) = 1e-35
 Identities = 21/24 (87%), Positives = 22/24 (91%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGK VTLQGNLDPCALYASE
Sbjct  237   ARERVGKMVTLQGNLDPCALYASE  260


 Score = 83.2 bits (204),  Expect(3) = 2e-32
 Identities = 35/36 (97%), Positives = 36/36 (100%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             QGFPELKNDTFLRAAWGE+TDYTPVWCMRQAGRYLP
Sbjct  9     QGFPELKNDTFLRAAWGEDTDYTPVWCMRQAGRYLP  44


 Score = 59.7 bits (143),  Expect(3) = 2e-32
 Identities = 26/27 (96%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EF+ETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFKETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 2e-32
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  130 bits (327),  Expect = 5e-28
 Identities = 64/69 (92%), Positives = 66/69 (95%), Gaps = 0/69 (0%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERLRDP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVM  2637
             IGFAGAP +
Sbjct  152   IGFAGAPAL  160


 Score =  108 bits (270),  Expect = 2e-21
 Identities = 50/59 (84%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV++MLDDFGP RYIANLGHGLYPDMDPEHVGAFVDAVHK+SRLLRQN
Sbjct  255   ALYASEEEIGRLVQKMLDDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKYSRLLRQN  313


>gi|57032914|gb|AAH88815.1|  LOC496978 protein [Xenopus tropicalis]
Length=367

 Score =  155 bits (392),  Expect = 2e-35
 Identities = 84/160 (52%), Positives = 100/160 (62%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGME+ M PG+GP FPEPL+  QDL +LR    V+ ELGYVF+AITLTR ++ G+VPL
Sbjct  93    QALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFRAITLTRHKIEGKVPL  152

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        MTYM+EGGGS+
Sbjct  153   IGFTGAP---------------WTL------------------------MTYMIEGGGSN  173

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM++AKRWLYQ P ASHQLL+ LTD +V YLVGQV AGAQ
Sbjct  174   TMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQ  213


 Score = 64.3 bits (155),  Expect(3) = 2e-25
 Identities = 28/37 (75%), Positives = 31/37 (83%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FP L NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  9     PECFPPLHNDTFLRAARGEECNHVPVWCMRQAGRYLP  45


 Score = 54.7 bits (130),  Expect(3) = 2e-25
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRA QDFF++CRSPE CCELTLQ
Sbjct  46    EFRETRAGQDFFASCRSPEICCELTLQ  72


 Score = 43.9 bits (102),  Expect(3) = 2e-25
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILV+PQ
Sbjct  71    LQPLRRFPLDAAIIFSDILVIPQ  93


 Score = 92.8 bits (229),  Expect(2) = 7e-23
 Identities = 51/133 (38%), Positives = 70/133 (52%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESHAG LGPQ F+ F+LPY+RD++++VK +L+  GL  VPM+             
Sbjct  214   ALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGLDQVPMI-------------  260

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+ALE+L+Q+GYEV
Sbjct  261   ----------------------------------------VFAKDAHYALEDLSQSGYEV  280

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P++AR
Sbjct  281   VGLDWTIRPQEAR  293


 Score = 41.6 bits (96),  Expect(2) = 7e-23
 Identities = 18/24 (75%), Positives = 21/24 (87%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE  GK VTLQGN+DPCALYAS+
Sbjct  292   ARERTGKRVTLQGNMDPCALYASK  315


 Score = 78.2 bits (191),  Expect = 3e-12
 Identities = 34/54 (62%), Positives = 44/54 (81%), Gaps = 0/54 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSR  4322
             AL   +E+I + VK+M++ FG   YIANLGHGLYPDMDP+HVGAF+ AVHK+S+
Sbjct  310   ALYASKEDIEKTVKKMIEGFGQRGYIANLGHGLYPDMDPDHVGAFISAVHKYSQ  363


>gi|49116745|gb|AAH73643.1|  MGC82980 protein [Xenopus laevis]
Length=367

 Score =  155 bits (391),  Expect = 2e-35
 Identities = 84/160 (52%), Positives = 100/160 (62%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGME+ M PG+GP FPEPL+  QDL +LR    V+ ELGYVF+AITLTR ++ G+VPL
Sbjct  93    QALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFRAITLTRHKIEGKVPL  152

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        MTYM+EGGGS+
Sbjct  153   IGFTGAP---------------WTL------------------------MTYMIEGGGSN  173

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM++AKRWLYQ P ASHQLL+ LTD +V YLVGQV AGAQ
Sbjct  174   TMSKAKRWLYQHPSASHQLLKQLTDIIVEYLVGQVAAGAQ  213


 Score = 64.7 bits (156),  Expect(3) = 2e-25
 Identities = 28/37 (75%), Positives = 31/37 (83%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FP L NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  9     PECFPSLHNDTFLRAARGEECNHVPVWCMRQAGRYLP  45


 Score = 54.7 bits (130),  Expect(3) = 2e-25
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRA QDFF++CRSPE CCELTLQ
Sbjct  46    EFRETRAGQDFFASCRSPEICCELTLQ  72


 Score = 43.9 bits (102),  Expect(3) = 2e-25
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILV+PQ
Sbjct  71    LQPLRRFPLDAAIIFSDILVIPQ  93


 Score = 92.8 bits (229),  Expect(2) = 7e-23
 Identities = 51/133 (38%), Positives = 70/133 (52%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESHAG LGPQ F+ F+LPY+RD++++VK +L+  GL  VPM+             
Sbjct  214   ALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGLDQVPMI-------------  260

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+ALE+L+Q+GYEV
Sbjct  261   ----------------------------------------VFAKDAHYALEDLSQSGYEV  280

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P++AR
Sbjct  281   VGLDWTIRPQEAR  293


 Score = 41.6 bits (96),  Expect(2) = 7e-23
 Identities = 18/24 (75%), Positives = 21/24 (87%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE  GK VTLQGN+DPCALYAS+
Sbjct  292   ARERTGKRVTLQGNMDPCALYASK  315


 Score = 75.9 bits (185),  Expect = 2e-11
 Identities = 34/54 (62%), Positives = 42/54 (77%), Gaps = 0/54 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSR  4322
             AL   + +I + VK M++ FG   YIANLGHGLYPDMDPEHVGAF+ AVHK+S+
Sbjct  310   ALYASKGDIEKTVKMMIEGFGRRGYIANLGHGLYPDMDPEHVGAFISAVHKYSQ  363


>gi|89886127|ref|NP_001011486.2|  hypothetical protein LOC496978 [Xenopus tropicalis]
 gi|89267848|emb|CAJ82884.1|  uroporphyrinogen decarboxylase [Xenopus tropicalis]
Length=372

 Score =  155 bits (391),  Expect = 2e-35
 Identities = 84/160 (52%), Positives = 99/160 (61%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGME+ M PG+GP FPEPL+  QDL +LR    V+ ELGYVF AITLTR ++ G+VPL
Sbjct  98    QALGMEIRMEPGRGPVFPEPLQTPQDLHKLRSSVDVSEELGYVFHAITLTRHKIEGKVPL  157

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        MTYM+EGGGS+
Sbjct  158   IGFTGAP---------------WTL------------------------MTYMIEGGGSN  178

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM++AKRWLYQ P ASHQLL+ LTD +V YLVGQV AGAQ
Sbjct  179   TMSKAKRWLYQHPSASHQLLKQLTDVIVEYLVGQVAAGAQ  218


 Score = 64.3 bits (155),  Expect(3) = 2e-25
 Identities = 28/37 (75%), Positives = 31/37 (83%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FP L NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  14    PECFPPLHNDTFLRAARGEECNHVPVWCMRQAGRYLP  50


 Score = 54.7 bits (130),  Expect(3) = 2e-25
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRA QDFF++CRSPE CCELTLQ
Sbjct  51    EFRETRAGQDFFASCRSPEICCELTLQ  77


 Score = 43.9 bits (102),  Expect(3) = 2e-25
 Identities = 21/23 (91%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILV+PQ
Sbjct  76    LQPLRRFPLDAAIIFSDILVIPQ  98


 Score = 92.8 bits (229),  Expect(2) = 7e-23
 Identities = 51/133 (38%), Positives = 70/133 (52%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESHAG LGPQ F+ F+LPY+RD++++VK +L+  GL  VPM+             
Sbjct  219   ALQVFESHAGCLGPQQFSDFSLPYLRDISRRVKHKLKAEGLDQVPMI-------------  265

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+ALE+L+Q+GYEV
Sbjct  266   ----------------------------------------VFAKDAHYALEDLSQSGYEV  285

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P++AR
Sbjct  286   VGLDWTIRPQEAR  298


 Score = 41.6 bits (96),  Expect(2) = 7e-23
 Identities = 18/24 (75%), Positives = 21/24 (87%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE  GK VTLQGN+DPCALYAS+
Sbjct  297   ARERTGKRVTLQGNMDPCALYASK  320


 Score = 78.2 bits (191),  Expect = 3e-12
 Identities = 34/54 (62%), Positives = 44/54 (81%), Gaps = 0/54 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSR  4322
             AL   +E+I + VK+M++ FG   YIANLGHGLYPDMDP+HVGAF+ AVHK+S+
Sbjct  315   ALYASKEDIEKTVKKMIEGFGQRGYIANLGHGLYPDMDPDHVGAFISAVHKYSQ  368


>gi|76614220|ref|XP_883334.1|  PREDICTED: similar to Uroporphyrinogen decarboxylase (URO-D) 
(UPD) isoform 3 [Bos taurus]
Length=313

 Score =  127 bits (319),  Expect(2) = 5e-35
 Identities = 73/133 (54%), Positives = 79/133 (59%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLF+KFALPYIRDV+K+VKA L+EAGLAPVPM+             
Sbjct  159   ALQLFESHAGHLGPQLFSKFALPYIRDVSKRVKAGLQEAGLAPVPMI-------------  205

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  206   ----------------------------------------IFAKDGHFALEELAQAGYEV  225

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTVAP+KAR
Sbjct  226   VGLDWTVAPEKAR  238


 Score = 47.8 bits (112),  Expect(2) = 5e-35
 Identities = 22/24 (91%), Positives = 23/24 (95%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +RE VGKTVTLQGNLDPCALYASE
Sbjct  237   ARERVGKTVTLQGNLDPCALYASE  260


 Score = 89.4 bits (220),  Expect(3) = 1e-34
 Identities = 38/39 (97%), Positives = 39/39 (100%), Gaps = 0/39 (0%)
 Frame = +3

Query  1743  ARPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             +RPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  6     SRPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  44


 Score = 60.8 bits (146),  Expect(3) = 1e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  45    EFRETRAAQDFFSTCRSPEACCELTLQ  71


 Score = 44.3 bits (103),  Expect(3) = 1e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  70    LQPLRRFPLDAAIIFSDILVVPQ  92


 Score =  129 bits (323),  Expect = 2e-27
 Identities = 63/69 (91%), Positives = 66/69 (95%), Gaps = 0/69 (0%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREE+DLERL+DP  VASELGYVFQAITLTRQRLAGRVPL
Sbjct  92    QALGMEVTMVPGKGPSFPEPLREERDLERLQDPATVASELGYVFQAITLTRQRLAGRVPL  151

Query  2611  IGFAGAPVM  2637
             IGFAGAP +
Sbjct  152   IGFAGAPAL  160


 Score =  110 bits (275),  Expect = 6e-22
 Identities = 51/59 (86%), Positives = 55/59 (93%), Gaps = 0/59 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  4337
             AL   +EEIG+LV+QML+DFGP RYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Sbjct  255   ALYASEEEIGKLVQQMLNDFGPQRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN  313


>gi|47216605|emb|CAG10903.1|  unnamed protein product [Tetraodon nigroviridis]
Length=368

 Score =  150 bits (379),  Expect = 5e-34
 Identities = 82/160 (51%), Positives = 102/160 (63%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGM V MV GKGP+FPEPL+E +DL++L+    V+ EL YVF+AITLTR +L G+VPL
Sbjct  93    QALGMSVQMVAGKGPTFPEPLKEPEDLQQLQAKVDVSKELDYVFKAITLTRHKLEGKVPL  152

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF+GAP               W +                        M+YM+EGGGSS
Sbjct  153   IGFSGAP---------------WTL------------------------MSYMIEGGGSS  173

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             T A+AKRWLY+ P+ASH LLR+LTD +V YL+GQV AGAQ
Sbjct  174   THAKAKRWLYRHPEASHMLLRMLTDVIVQYLLGQVAAGAQ  213


 Score = 67.4 bits (163),  Expect(3) = 8e-25
 Identities = 29/37 (78%), Positives = 32/37 (86%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQ FP+L NDTFLRAA GE+T + PVWCMRQAGRYLP
Sbjct  9     PQDFPQLLNDTFLRAARGEDTPHVPVWCMRQAGRYLP  45


 Score = 50.8 bits (120),  Expect(3) = 8e-25
 Identities = 21/27 (77%), Positives = 23/27 (85%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFR+ R  +DFF TCRSPEACCELTLQ
Sbjct  46    EFRKAREGRDFFDTCRSPEACCELTLQ  72


 Score = 42.7 bits (99),  Expect(3) = 8e-25
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF  DAAIIFSDILVVPQ
Sbjct  71    LQPLRRFPFDAAIIFSDILVVPQ  93


 Score = 84.7 bits (208),  Expect(2) = 9e-19
 Identities = 52/133 (39%), Positives = 67/133 (50%), Gaps = 54/133 (40%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESHAG LGP  F +F+L Y+RD+A++VK +L+EAG   VPMV             
Sbjct  214   ALQVFESHAGILGPAEFKEFSLAYLRDIARRVKEKLKEAG-QDVPMV-------------  259

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKD H+ALE+L+Q+ YEV
Sbjct  260   ----------------------------------------VFAKDAHYALEDLSQSHYEV  279

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWTV P+ AR
Sbjct  280   VGLDWTVDPRSAR  292


 Score = 35.8 bits (81),  Expect(2) = 9e-19
 Identities = 15/23 (65%), Positives = 19/23 (82%), Gaps = 0/23 (0%)
 Frame = +1

Query  3772  ASRECVGKTVTLQGNLDPCALYA  3840
             ++RE  G  V+LQGN+DPCALYA
Sbjct  290   SARERTGGKVSLQGNMDPCALYA  312


 Score = 84.7 bits (208),  Expect = 3e-14
 Identities = 42/71 (59%), Positives = 53/71 (74%), Gaps = 1/71 (1%)
 Frame = +3

Query  4125  GGQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDA  4304
             G   L G     AL  P+E I ++VK+ML+ FG   YIANLGHGLYPDMDPE+VGAFV+A
Sbjct  297   GKVSLQGNMDPCALYAPKEHISRIVKKMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEA  356

Query  4305  VHKHSR-LLRQ  4334
             VH+HS+ +L+Q
Sbjct  357   VHRHSKEMLKQ  367


>gi|55959136|emb|CAI16441.1|  uroporphyrinogen decarboxylase [Homo sapiens]
Length=227

 Score = 87.0 bits (214),  Expect(3) = 5e-34
 Identities = 37/37 (100%), Positives = 37/37 (100%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
Sbjct  1     PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  37


 Score = 60.8 bits (146),  Expect(3) = 5e-34
 Identities = 27/27 (100%), Positives = 27/27 (100%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRETRAAQDFFSTCRSPEACCELTLQ
Sbjct  38    EFRETRAAQDFFSTCRSPEACCELTLQ  64


 Score = 44.3 bits (103),  Expect(3) = 5e-34
 Identities = 22/23 (95%), Positives = 22/23 (95%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF LDAAIIFSDILVVPQ
Sbjct  63    LQPLRRFPLDAAIIFSDILVVPQ  85


 Score =  135 bits (341),  Expect = 1e-29
 Identities = 67/69 (97%), Positives = 68/69 (98%), Gaps = 0/69 (0%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL
Sbjct  85    QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  144

Query  2611  IGFAGAPVM  2637
             IGFAGAP +
Sbjct  145   IGFAGAPAL  153


 Score =  130 bits (327),  Expect = 5e-28
 Identities = 75/129 (58%), Positives = 76/129 (58%), Gaps = 53/129 (41%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPM+             
Sbjct  152   ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMI-------------  198

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     IFAKDGHFALEELAQAGYEV
Sbjct  199   ----------------------------------------IFAKDGHFALEELAQAGYEV  218

Query  3639  VGLDWTVAP  3665
             VGLDWTVAP
Sbjct  219   VGLDWTVAP  227


>gi|18859531|ref|NP_571422.1|  uroporphyrinogen decarboxylase [Danio rerio]
 gi|6502530|gb|AAF14346.1|  uroporphyrinogen decarboxylase [Danio rerio]
 gi|20138048|sp|Q9PTS2|DCUP_BRARE  Uroporphyrinogen decarboxylase (URO-D) (UPD)
Length=369

 Score =  147 bits (370),  Expect = 6e-33
 Identities = 80/160 (50%), Positives = 101/160 (63%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QA+GMEV M PGKGP+FPEPL+E +DL+RL+    V SEL YVF+AITLTR ++ G+VPL
Sbjct  94    QAMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPL  153

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        M+YM+EGGGS+
Sbjct  154   IGFTGAP---------------WTL------------------------MSYMIEGGGSA  174

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             T ++AKRWLY+ P+ASH+LL  LTD +V YL+GQV AGAQ
Sbjct  175   THSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQ  214


 Score = 68.2 bits (165),  Expect(3) = 4e-26
 Identities = 29/37 (78%), Positives = 33/37 (89%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FPEL+NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  10    PKDFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLP  46


 Score = 54.7 bits (130),  Expect(3) = 4e-26
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRE+RA +DFF TCRSPEACCELTLQ
Sbjct  47    EFRESRAGKDFFETCRSPEACCELTLQ  73


 Score = 42.7 bits (99),  Expect(3) = 4e-26
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF  DAAIIFSDILVVPQ
Sbjct  72    LQPLRRFPFDAAIIFSDILVVPQ  94


 Score = 88.6 bits (218),  Expect(2) = 7e-19
 Identities = 48/133 (36%), Positives = 68/133 (51%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESH G LGP  F +F+LPY+RD+A++VK +++E+GL  VPM+             
Sbjct  215   ALQVFESHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGLDNVPMI-------------  261

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKDGH+ LE+L+++ YEV
Sbjct  262   ----------------------------------------VFAKDGHYGLEDLSESAYEV  281

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P+ AR
Sbjct  282   VGLDWTIDPRSAR  294


 Score = 32.3 bits (72),  Expect(2) = 7e-19
 Identities = 13/25 (52%), Positives = 19/25 (76%), Gaps = 0/25 (0%)
 Frame = +1

Query  3772  ASRECVGKTVTLQGNLDPCALYASE  3846
             ++R   G  V+LQGN+DPCALY ++
Sbjct  292   SARVRTGGKVSLQGNMDPCALYGTK  316


 Score = 80.5 bits (197),  Expect = 6e-13
 Identities = 40/68 (58%), Positives = 48/68 (70%), Gaps = 0/68 (0%)
 Frame = +3

Query  4125  GGQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDA  4304
             G   L G     AL   +E I ++V++ML+ FG   YIANLGHGLYPDMDPE+VGAFV+A
Sbjct  299   GKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEA  358

Query  4305  VHKHSRLL  4328
             VH HSR L
Sbjct  359   VHNHSRQL  366


>gi|62204806|gb|AAH92696.1|  Urod protein [Danio rerio]
Length=402

 Score =  145 bits (367),  Expect = 1e-32
 Identities = 80/160 (50%), Positives = 100/160 (62%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QA+GMEV M PGKGP+FPEPL+E +DL+RL+    V SEL YVF+AITLTR ++ G+VPL
Sbjct  127   QAMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPL  186

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        M+YM+EGGGS 
Sbjct  187   IGFTGAP---------------WTL------------------------MSYMIEGGGSV  207

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             T ++AKRWLY+ P+ASH+LL  LTD +V YL+GQV AGAQ
Sbjct  208   THSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQ  247


 Score = 68.2 bits (165),  Expect(3) = 1e-25
 Identities = 29/37 (78%), Positives = 33/37 (89%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FPEL+NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  43    PKDFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLP  79


 Score = 52.8 bits (125),  Expect(3) = 1e-25
 Identities = 22/27 (81%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRE+RA ++FF TCRSPEACCELTLQ
Sbjct  80    EFRESRAGKNFFETCRSPEACCELTLQ  106


 Score = 42.7 bits (99),  Expect(3) = 1e-25
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF  DAAIIFSDILVVPQ
Sbjct  105   LQPLRRFPFDAAIIFSDILVVPQ  127


 Score = 86.3 bits (212),  Expect(2) = 3e-18
 Identities = 48/133 (36%), Positives = 66/133 (49%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FESH G LGP  F +F+LPY+RD A++VK +++E+GL  VPM+             
Sbjct  248   ALQVFESHTGCLGPVEFKEFSLPYLRDTARRVKDKIKESGLDNVPMI-------------  294

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKDGH+ LE+L+++ YEV
Sbjct  295   ----------------------------------------VFAKDGHYGLEDLSESAYEV  314

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P  AR
Sbjct  315   VGLDWTIDPHSAR  327


 Score = 32.3 bits (72),  Expect(2) = 3e-18
 Identities = 13/25 (52%), Positives = 19/25 (76%), Gaps = 0/25 (0%)
 Frame = +1

Query  3772  ASRECVGKTVTLQGNLDPCALYASE  3846
             ++R   G  V+LQGN+DPCALY ++
Sbjct  325   SARVRTGGKVSLQGNMDPCALYGTK  349


 Score = 80.5 bits (197),  Expect = 6e-13
 Identities = 40/68 (58%), Positives = 48/68 (70%), Gaps = 0/68 (0%)
 Frame = +3

Query  4125  GGQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDA  4304
             G   L G     AL   +E I ++V++ML+ FG   YIANLGHGLYPDMDPE+VGAFV+A
Sbjct  332   GKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEA  391

Query  4305  VHKHSRLL  4328
             VH HSR L
Sbjct  392   VHNHSRQL  399


>gi|79160119|gb|AAI08076.1|  Urod protein [Danio rerio]
Length=369

 Score =  145 bits (367),  Expect = 1e-32
 Identities = 80/160 (50%), Positives = 100/160 (62%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QA+GMEV M PGKGP+FPEPL+E +DL+RL+    V SEL YVF+AITLTR ++ G+VPL
Sbjct  94    QAMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPL  153

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        M+YM+EGGGS 
Sbjct  154   IGFTGAP---------------WTL------------------------MSYMIEGGGSV  174

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             T ++AKRWLY+ P+ASH+LL  LTD +V YL+GQV AGAQ
Sbjct  175   THSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQ  214


 Score = 68.2 bits (165),  Expect(3) = 4e-26
 Identities = 29/37 (78%), Positives = 33/37 (89%), Gaps = 0/37 (0%)
 Frame = +3

Query  1749  PQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             P+ FPEL+NDTFLRAA GEE ++ PVWCMRQAGRYLP
Sbjct  10    PKDFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLP  46


 Score = 54.7 bits (130),  Expect(3) = 4e-26
 Identities = 23/27 (85%), Positives = 25/27 (92%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EFRE+RA +DFF TCRSPEACCELTLQ
Sbjct  47    EFRESRAGKDFFETCRSPEACCELTLQ  73


 Score = 42.7 bits (99),  Expect(3) = 4e-26
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPLRRF  DAAIIFSDILVVPQ
Sbjct  72    LQPLRRFPFDAAIIFSDILVVPQ  94


 Score = 86.7 bits (213),  Expect(2) = 3e-18
 Identities = 47/133 (35%), Positives = 67/133 (50%), Gaps = 53/133 (39%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWS  3458
             ALQ+FE H G LGP  F +F+LPY+RD+A++VK +++E+GL  VPM+             
Sbjct  215   ALQVFEPHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGLDNVPMI-------------  261

Query  3459  FQAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEV  3638
                                                     +FAKDGH+ LE+L+++ YEV
Sbjct  262   ----------------------------------------VFAKDGHYGLEDLSESAYEV  281

Query  3639  VGLDWTVAPKKAR  3677
             VGLDWT+ P+ AR
Sbjct  282   VGLDWTIDPRSAR  294


 Score = 32.3 bits (72),  Expect(2) = 3e-18
 Identities = 13/25 (52%), Positives = 19/25 (76%), Gaps = 0/25 (0%)
 Frame = +1

Query  3772  ASRECVGKTVTLQGNLDPCALYASE  3846
             ++R   G  V+LQGN+DPCALY ++
Sbjct  292   SARVRTGGKVSLQGNMDPCALYGTK  316


 Score = 80.5 bits (197),  Expect = 6e-13
 Identities = 40/68 (58%), Positives = 48/68 (70%), Gaps = 0/68 (0%)
 Frame = +3

Query  4125  GGQRLAGPPVASALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDA  4304
             G   L G     AL   +E I ++V++ML+ FG   YIANLGHGLYPDMDPE+VGAFV+A
Sbjct  299   GKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEA  358

Query  4305  VHKHSRLL  4328
             VH HSR L
Sbjct  359   VHNHSRQL  366


>gi|72004376|ref|XP_784308.1|  PREDICTED: similar to uroporphyrinogen decarboxylase [Strongylocentrotus 
purpuratus]
Length=372

 Score =  134 bits (338),  Expect = 3e-29
 Identities = 74/161 (45%), Positives = 93/161 (57%), Gaps = 39/161 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALG+ V M+PG GPSFPEPL    DL RL     +   L YVF+A+TLTR+ L G+VPL
Sbjct  94    QALGLTVEMIPGTGPSFPEPLTSPDDLSRLNAEVDINQALSYVFEALTLTRKELDGKVPL  153

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF+GAP               W +                        M Y +EGGGS 
Sbjct  154   IGFSGAP---------------WTL------------------------MVYCIEGGGSK  174

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV  2913
             T ++AK+WLY +P ASH+LL+ILT  +V YLVGQV+AGAQ+
Sbjct  175   TFSKAKKWLYTQPDASHKLLKILTRTIVDYLVGQVLAGAQL  215


 Score = 74.3 bits (181),  Expect = 5e-11
 Identities = 32/58 (55%), Positives = 42/58 (72%), Gaps = 0/58 (0%)
 Frame = +3

Query  4161  ALLVPQEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQ  4334
             A+   +E+I   V QML+ FG   YIANLGHG+YPD DPEHV AF+D+VH+HS  + +
Sbjct  311   AIYSSKEDISSYVAQMLERFGTQSYIANLGHGIYPDFDPEHVRAFIDSVHQHSERMNK  368


 Score = 60.1 bits (144),  Expect(2) = 2e-10
 Identities = 38/132 (28%), Positives = 55/132 (41%), Gaps = 53/132 (40%)
 Frame = +3

Query  3282  LQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMVRIGMG*VKVVLWSF  3461
             LQ+F+SHAG LG   F +F LPY++ +AK+VK +LR   + PVPM+    G         
Sbjct  216   LQVFDSHAGALGYDKFCQFCLPYLQQIAKEVKEKLRAKSVEPVPMIVFAKG---------  266

Query  3462  QAKSCMDWSDHWRAAEVQSRKISGCSKALCSLRSAFF*IIFAKDGHFALEELAQAGYEVV  3641
                                                          ++A+ EL+Q  Y+V+
Sbjct  267   --------------------------------------------ANYAISELSQCDYDVM  282

Query  3642  GLDWTVAPKKAR  3677
              LDW V P+ AR
Sbjct  283   SLDWDVQPQIAR  294


 Score = 32.0 bits (71),  Expect(2) = 2e-10
 Identities = 13/24 (54%), Positives = 17/24 (70%), Gaps = 0/24 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASE  3846
             +R   G    LQGNLDPCA+Y+S+
Sbjct  293   ARAQAGPNFPLQGNLDPCAIYSSK  316


 Score = 40.8 bits (94),  Expect(2) = 2e-06
 Identities = 19/23 (82%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQP+RRF LDAAIIF DILV+PQ
Sbjct  72    LQPIRRFDLDAAIIFCDILVIPQ  94


 Score = 38.1 bits (87),  Expect(2) = 2e-06
 Identities = 24/53 (45%), Positives = 28/53 (52%), Gaps = 7/53 (13%)
 Frame = +1

Query  1900  GEKFSRGRGGLWR-ASRLSPVFPLYAEFRETRAAQDFFSTCRSPEACCELTLQ  2055
             GEK  R    L R A R  P      EFRE RA  +FF  C++P   CE+TLQ
Sbjct  27    GEKTERVPVWLMRQAGRYLP------EFREMRAEHNFFKVCQTPALACEVTLQ  73


 Score = 56.6 bits (135),  Expect = 1e-05
 Identities = 26/36 (72%), Positives = 28/36 (77%), Gaps = 0/36 (0%)
 Frame = +3

Query  1752  QGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             Q FP LKND  LRAA GE+T+  PVW MRQAGRYLP
Sbjct  11    QQFPALKNDLILRAARGEKTERVPVWLMRQAGRYLP  46


>gi|66801513|ref|XP_629682.1|  uroporphyrinogen decarboxylase [Dictyostelium discoideum]
 gi|60463076|gb|EAL61271.1|  uroporphyrinogen decarboxylase [Dictyostelium discoideum AX4]
Length=364

 Score =  131 bits (330),  Expect = 2e-28
 Identities = 71/160 (44%), Positives = 91/160 (56%), Gaps = 39/160 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QA+G+EV M+PGKGP FP P+R  +DL R++ P  V  ELGYVF A+TLTR+RL GRVPL
Sbjct  92    QAMGIEVQMIPGKGPFFPNPIRTIEDLSRVQFPVDVNKELGYVFDALTLTRKRLEGRVPL  151

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        MTY +EG G +
Sbjct  152   IGFTGAP---------------WTL------------------------MTYCIEGSGGT  172

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQ  2910
             TM+ +K WLY+ P  SH+ L +LT   + YL+GQ+ AGAQ
Sbjct  173   TMSNSKSWLYKHPAESHKFLSMLTRVCIDYLLGQIKAGAQ  212


 Score = 61.6 bits (148),  Expect(3) = 2e-19
 Identities = 27/34 (79%), Positives = 28/34 (82%), Gaps = 0/34 (0%)
 Frame = +3

Query  1758  FPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP  1859
             FPELKNDTFL+A  GEE  Y PVW MRQAGRYLP
Sbjct  11    FPELKNDTFLKACRGEEVPYVPVWIMRQAGRYLP  44


 Score = 41.6 bits (96),  Expect(3) = 2e-19
 Identities = 21/23 (91%), Positives = 21/23 (91%), Gaps = 0/23 (0%)
 Frame = +2

Query  2126  LQPLRRFLLDAAIIFSDILVVPQ  2194
             LQPL RF LDAAIIFSDILVVPQ
Sbjct  70    LQPLDRFPLDAAIIFSDILVVPQ  92


 Score = 39.7 bits (91),  Expect(3) = 2e-19
 Identities = 16/27 (59%), Positives = 20/27 (74%), Gaps = 0/27 (0%)
 Frame = +1

Query  1975  EFRETRAAQDFFSTCRSPEACCELTLQ  2055
             EF+  RA  DFFS CR+PE  C++TLQ
Sbjct  45    EFKSVRADVDFFSVCRTPELACKVTLQ  71


 Score = 43.1 bits (100),  Expect(2) = 3e-06
 Identities = 19/35 (54%), Positives = 28/35 (80%), Gaps = 1/35 (2%)
 Frame = +3

Query  3576  IIFAKDGHFALEELAQAG-YEVVGLDWTVAPKKAR  3677
             I FAK  +FALE+L+++G Y+V+G+DWT+ P  AR
Sbjct  254   ICFAKGSNFALEDLSKSGAYDVLGIDWTIEPSVAR  288


 Score = 35.0 bits (79),  Expect(2) = 3e-06
 Identities = 15/28 (53%), Positives = 18/28 (64%), Gaps = 0/28 (0%)
 Frame = +1

Query  3775  SRECVGKTVTLQGNLDPCALYASEVTAR  3858
             +RE V   V+LQGNLDPC LY  +   R
Sbjct  287   AREMVADRVSLQGNLDPCVLYCGDQVIR  314


 Score = 38.5 bits (88),  Expect = 2.8
 Identities = 15/34 (44%), Positives = 24/34 (70%), Gaps = 0/34 (0%)
 Frame = +3

Query  3279  ALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKA  3380
             ALQ+F+S +  L P +F ++ LPY+  + K+VKA
Sbjct  213   ALQIFDSWSNELSPAMFKEYCLPYLVQIGKEVKA  246


>gi|58262678|ref|XP_568749.1|  uroporphyrinogen decarboxylase [Cryptococcus neoformans var. 
neoformans JEC21]
 gi|57223399|gb|AAW41442.1|  uroporphyrinogen decarboxylase, putative [Cryptococcus neoformans 
var. neoformans JEC21]
Length=380

 Score =  125 bits (313),  Expect = 2e-26
 Identities = 71/161 (44%), Positives = 88/161 (54%), Gaps = 39/161 (24%)
 Frame = +1

Query  2431  QALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPL  2610
             QALG+EV M P +GP  P PL    D++RLR    V  ELGYVF+A+TLTR+ L GRVPL
Sbjct  101   QALGLEVLMEPSRGPVLPNPLVTPDDIKRLRKDVDVQKELGYVFEAVTLTRKGLDGRVPL  160

Query  2611  IGFAGAPVMWDRAGTRGAGRSLWKVWGRQKEGSVwll*hhlsill*wtlMTYMVEGGGSS  2790
             IGF GAP               W +                        M YM EGGGS 
Sbjct  161   IGFCGAP---------------WTL------------------------MAYMCEGGGSK  181

Query  2791  TMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQV  2913
             T  ++K WLY+ P+ASH+LLR + D     L+GQV+AGAQ+
Sbjct  182   TFEKSKSWLYKYPEASHELLRRIADVCADLLIGQVLAGAQM  222






  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding 
environmental samples
    Posted date:  May 6, 2006  3:28 AM
  Number of letters in database: 1,248,697,171
  Number of sequences in database:  3,632,049
Lambda     K      H
   0.318    0.134    0.401 
Gapped
Lambda     K      H
   0.267   0.0410    0.140 
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 3632049
Number of Hits to DB: 550749794
Number of extensions: 13075774
Number of successful extensions: 35617
Number of sequences better than 10: 38
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 35541
Number of HSP's successfully gapped: 196
Length of query: 4514
Length of database: 1248697171
Length adjustment: 143
Effective length of query: 4371
Effective length of database: 729314164
Effective search space: 992596577204
Effective search space used: 992596577204
T: 12
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 83 (36.6 bits)