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I obtained my phD from the Universitat de
Barcelona in late 1988. I worked at the Department of Statistics
in the School of Biology, where
Dr. Jordi Ocaña was my advisor. We worked in the development of
mathematical and computer models in Population Genetics and Evolutionary
Ecology. After finishing my phD thesis, I went to the
Molecular Biology Computer Research Resource at the
Dana Farber Cancer Institute---
Harvard University (
Division of Biostatistics). I was a postdoctoral fellow with
Dr. Temple F. Smith. In late 1991, I moved to the BioMolecular Engineering Research
Center at Boston University,
when Temple F. Smith was named director. During these years,
I was involved in several projects in the field of sequence analysis:
gene identification, automatic knowledge extraction from biosequence
databases, protein sequence pattern analysis, and molecular
evolution. On Spring 1992, I moved to
Los Alamos National Laboratory , where I was a postdoctoral fellow
at the Theoretical Biology and
Biophysics Group with Dr. James W. Fickett. At Los Alamos I
worked essentially on genome analysis related problems: estimation of
genome's protein coding density, and characterization of large scale
genome structure. Since 1994 I am a researcher at the Institut Municipal d'Investigació
Mèdica, within the
Grup de Recerca en Informàtica
Biomèdica (GRIB). Since year 1999, I am also associated professor with the Universitat Pompeu Fabra. During the
period 1994-1999 I was associated with the Department of Statistics of
the Universitat de Barcelona.
Since year 2005 I am coordinating the Bioinformatics and Genomics
program of the Centre de Regualció Genòmica
in Barcelona.
My email:
rguigo@imim.es
Genome Informatics and Sequence Analysis. Any computational/statistical
problem arising in the pathway from DNA sequences to protein structures.
Gene Identification. Evolution of Genome Structure. Reconstruction of
Molecular Phylogenies. Machine Learning from Biosequence Databases.
See publications
at the Genome BIoinformatics Laboratory for publications from 1995.
- J. W. Fickett and R. Guigó.
"Estimation of protein coding density in a corpus of DNA sequence data."
Nucleic Acids Research, 20:2837-2844 (1993).
- R. Guigó, I. Vázquez, S. Rao and T.F. Smith.
"A protein sequence database cross-field association system"
Proceedings of The 26th Hawaii International Conference on System Sciences: Biotechnology Computing, 1993:822-833. IEEE Computer Society Press, Los Alamitos (1993)
- R. Guigó and T.F. Smith.
"Inferring correlation between database queries: Analysis of protein sequence patterns."
IEEE Transactions on Pattern Analysis and Machine Intelligence, 15:1030-1041 (1993).
- R. Guigó, S. Knudsen, N. Drake, and T. F. Smith.
"Prediction of gene structure."
Journal of Molecular Biology, 226:141-157 (1992).
- R. Guigó and T.F. Smith.
"A common pattern between tgf-beta family and glutaredoxin."
Biochemical Journal, 280:833-834 (1991).
- R. Guigó, A. Johansson, and T.F. Smith.
"Automatic evaluation of protein sequence patterns."
Computer Applications to Biosciences, 7:309-315 (1991).
- M.A. Vega, R. Guigó and T.F. Smith.
"Autoimmune response in AIDS."
Nature, 345:26 (1990).
- R. Guigó and J. Ocaña.
"An interactive support software for design and use of simulation packages."
Mathematical and Computer Modelling, 11:1205-1207 (1988).
- R. Guigó and F. Luna.
"Proyección de la población de un municipio agrícola andaluz de gran
crecimiento demográfico."
Trabajos de Antropología, 21:121-127 (1988).
- J. Gosàlbez, J. Ventura, and R. Guigó.
"A distinguishing criteria for Mycrotus pirenaicus and Mycrotus duodecimcostatus based on biometrical characters of the mandible."
Saugetierkundliche Mitteilungen, 13:175-178 (1985).
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